| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30042879 | HIV | ENSG00000129214.15 | protein_coding | SHBG | No | No | 6462 | B0FWH2 B0FWH8 B4DYU0 I3L145 P04278 |
| TVIS44036820 | HTLV-1 | ENSG00000129214.15 | protein_coding | SHBG | No | No | 6462 | B0FWH2 B0FWH8 B4DYU0 I3L145 P04278 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SHBG |
|---|---|
| DrugBank ID | DB00675 |
| Drug Name | Tamoxifen |
| Target ID | BE0000685 |
| UniProt ID | P04278 |
| Regulation Type | inducer |
| PubMed IDs | 25349334; 27083550 |
| Citations | Hong H, Branham WS, Ng HW, Moland CL, Dial SL, Fang H, Perkins R, Sheehan D, Tong W: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and alpha-fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.@@Radin DP, Patel P: Delineating the molecular mechanisms of tamoxifen's oncolytic actions in estrogen receptor-negative cancers. Eur J Pharmacol. 2016 Jun 15;781:173-80. doi: 10.1016/j.ejphar.2016.04.017. Epub 2016 Apr 12. |
| Groups | Approved |
| Direct Classification | Stilbenes |
| SMILES | CCC(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1 |
| Pathways | Tamoxifen Metabolism Pathway; Tamoxifen Action Pathway |
| PharmGKB | PA451581 |
| ChEMBL | CHEMBL83 |
