DrugBank ID	Drug Name	Target ID	Gene Symbol	UniProt ID	UniProt Entry	Regulation Type	PubMed IDs	Citations	Groups	Direct Classification	Detailed Classification	Categories	SMILES	PubChem ID	Pathways	Pathway Sources	KEGG Pathway IDs	DPD	PubChem Substance	KEGG Drug	PharmGKB	UniProtKB	TTD	Wikipedia	ChEMBL	RxCUI
DB00131	Adenosine phosphate	BE0000958	CREB1	P16220	CREB1_HUMAN	activator	16879221; 17083486; 17122581; 17300755; 17324065	"Ulfhammer E, Larsson P, Karlsson L, Hrafnkelsdottir T, Bokarewa M, Tarkowski A, Jern S: TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB- and p38 MAPK-dependent. J Thromb Haemost. 2006 Aug;4(8):1781-9.@@Saha B, Singh SK, Sarkar C, Bera R, Ratha J, Tobin DJ, Bhadra R: Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB. Pigment Cell Res. 2006 Dec;19(6):595-605.@@Kozinn J, Mao L, Arora A, Yang L, Fibuch EE, Wang JQ: Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol. Anesthesiology. 2006 Dec;105(6):1182-91.@@Perlis RH, Purcell S, Fagerness J, Cusin C, Yamaki L, Fava M, Smoller JW: Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. Biol Psychiatry. 2007 Sep 1;62(5):536-40. Epub 2007 Feb 14.@@Brenhouse HC, Howe ML, Stellar JR: Differential activation of cAMP response element binding protein in discrete nucleus accumbens subregions during early and late cocaine sensitization. Behav Neurosci. 2007 Feb;121(1):212-7."	Approved; Investigational; Nutraceutical; Withdrawn	Purine ribonucleoside monophosphates	"Organic compounds; Nucleosides, nucleotides, and analogues; Purine nucleotides; Purine ribonucleotides"	"Supplements; Heterocyclic Compounds, Fused-Ring; Adenine Nucleotides; Purines; Purine Nucleotides; Ribonucleotides; Nucleic Acids, Nucleotides, and Nucleosides; Nucleotides; Dietary Supplements"	NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1		Leigh Syndrome; Histidinemia; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Fatty Acid Metabolism; Gentamicin Action Pathway; Pyruvate Dehydrogenase Complex Deficiency; Purine Nucleoside Phosphorylase Deficiency; Hyperprolinemia Type II; Glutamate Metabolism; Clarithromycin Action Pathway; Argininosuccinic Aciduria; Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency); Hyperinsulinism-Hyperammonemia Syndrome; Butyrate Metabolism; Pyruvate Metabolism; Pentose Phosphate Pathway; Propanoate Metabolism; Glycine and Serine Metabolism; Selenoamino Acid Metabolism; Thiamine Metabolism; Oxytetracycline Action Pathway; Tetracycline Action Pathway; Carbamoyl Phosphate Synthetase Deficiency; Hyperprolinemia Type I; Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Arginine and Proline Metabolism; Roxithromycin Action Pathway; Purine Metabolism; Ammonia Recycling	disease; metabolic; drug_action			46507628	D02769	PA164744376		DAP001319	Adenosine_monophosphate	CHEMBL752	309
DB01183	Naloxone	BE0000958	CREB1	P16220	CREB1_HUMAN	other/unknown	12956944; 12969258; 14653953; 15953421; 16417577	"Li J, Li YH, Yuan XR: Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversal. Acta Pharmacol Sin. 2003 Sep;24(9):930-6.@@Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA Jr: Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem. 2003 Oct;87(1):107-18.@@Gao C, Chen LW, Tao YM, Chen J, Xu XJ, Chi ZQ: Effects of ohmefentanyl stereoisomers on phosphorylation of cAMP- response element binding protein in cultured rat hippocampal neurons. Acta Pharmacol Sin. 2003 Dec;24(12):1253-8.@@Walters CL, Cleck JN, Kuo YC, Blendy JA: Mu-opioid receptor and CREB activation are required for nicotine reward. Neuron. 2005 Jun 16;46(6):933-43.@@Hawes JJ, Narasimhaiah R, Picciotto MR: Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. J Neurochem. 2006 Feb;96(4):1160-8. Epub 2006 Jan 17."	Approved; Vet_approved	Phenanthrenes and derivatives	Organic compounds; Benzenoids; Phenanthrenes and derivatives	"Sensory System Agents; Cytochrome P-450 CYP3A Substrates; Opioid Antagonists; Natural Opium Alkaloids; Cytochrome P-450 Substrates; Cytochrome P-450 Enzyme Inhibitors; Alkaloids; Cytochrome P-450 CYP3A Inhibitors; Drugs that are Mainly Renally Excreted; P-glycoprotein substrates; Cytochrome P-450 CYP3A4 Inhibitors; Alimentary Tract and Metabolism; Cytochrome P-450 CYP2C19 Substrates; Heterocyclic Compounds, Fused-Ring; Antidotes; Cytochrome P-450 CYP3A4 Inhibitors (strength unknown); Peripheral Opioid Receptor Antagonists; Cytochrome P-450 CYP3A4 Substrates; Peripheral Nervous System Agents; Analgesics; Cytochrome P-450 CYP2C18 Substrates; Phenanthrenes; Morphinans; Central Nervous System Agents; UGT1A1 Substrates; Cytochrome P-450 CYP3A4 Inhibitors (strong); Nervous System; Opiate Alkaloids; Opiate Antagonists; Drugs for Constipation"	OC1=CC=C2C[C@H]3N(CC=C)CC[C@@]45[C@@H](OC1=C24)C(=O)CC[C@@]35O		Naloxone Action Pathway	drug_action		20137	46508816	D08249	PA450586		DAP000097	Naloxone	CHEMBL80	7242