Gene info: ID 1767

Gene: DNAH5

GENE ID: 1767

Synonyms: CILD3|DNAHC5|HL1|KTGNR|PCD

Description: dynein axonemal heavy chain 5

Gene type: protein-coding

Location: 5p15.2

dbXrefs: Ensembl:ENSG00000039139 MIM:603335 Vega:OTTHUMG00000090533 UniprotKB:Q8TE73

RefSeq: NG_013081.1

Retrived from: PubMed|SNP Mapped

SNPs: 5 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.513e-1 (AD) 3.083e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7727798	chr5:13993421 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs10055489	chr5:13987357 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs1031006	chr5:13986994 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs17292523	chr5:13985770 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs16902820	chr5:13834597 (GRCh38.p7)	T>C / T>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
E2F3	0.746
RAB36	0.72
PRKDC	0.715
GTF3C4	0.714
RNF150	0.713
DHX33	0.709
CDC40	0.706
SLC35B4	0.704
WDR17	0.704
ANKRD6	0.703

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TGFB3	-0.394
BCAS1	-0.393
CDKN2C	-0.391
KIF1C	-0.383
KLRK1	-0.361
CTNNA3	-0.358
KLRC3	-0.356
PAIP2B	-0.356
GNG8	-0.355
MCM7	-0.352

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DNAH5 mRNA"	19114083
D000082	Acetaminophen	MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAH5 mRNA]	18700144
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DNAH5 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DNAH5 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of DNAH5 mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNAH5 mRNA	22316170
C006780	bisphenol A	bisphenol A results in decreased expression of DNAH5 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DNAH5 mRNA	22079614
C018475	butyraldehyde	butyraldehyde results in decreased expression of DNAH5 mRNA	26079696
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH5 mRNA	20360939
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of DNAH5 mRNA	20971185
D003471	Cuprizone	Cuprizone results in decreased expression of DNAH5 mRNA	27523638
D003471	Cuprizone	Cuprizone results in increased expression of DNAH5 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of DNAH5 mRNA	20106945
D003671	DEET	DEET results in decreased expression of DNAH5 mRNA	27091632
D004041	Dietary Fats	Dietary Fats results in increased expression of DNAH5 mRNA	25016146
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DNAH5 mRNA	20360939
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of DNAH5 mRNA	27776689
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DNAH5 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DNAH5 mRNA"	20188158
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of DNAH5 mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DNAH5 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DNAH5 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of DNAH5 mRNA	25583101
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of DNAH5 mRNA	20971185
D010100	Oxygen	Oxygen deficiency results in increased expression of DNAH5 mRNA	26516004
C046012	pentanal	pentanal results in decreased expression of DNAH5 mRNA	26079696
C006253	pirinixic acid	pirinixic acid results in increased expression of DNAH5 mRNA	12832660
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of DNAH5 mRNA	25895662
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DNAH5 mRNA	20106945\|2163298
C009495	titanium dioxide	titanium dioxide results in decreased expression of DNAH5 mRNA	23557971
D014635	Valproic Acid	Valproic Acid results in increased expression of DNAH5 mRNA	26705709
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of DNAH5 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005524	ATP binding	-	IEA	-
GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	-	IBA	21873635
GO:0045503	dynein light chain binding	-	IBA	21873635
GO:0045505	dynein intermediate chain binding	-	IBA	21873635
GO:0051959	dynein light intermediate chain binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003341	cilium movement	-	IMP	11062149 15750039 16627867 23261302
GO:0007018	microtubule-based movement	-	IBA	21873635
GO:0007368	determination of left/right symmetry	-	IMP	11788826 17515466 22499950
GO:0030317	flagellated sperm motility	-	IMP	15750039 18492703
GO:0036158	outer dynein arm assembly	-	IBA	21873635
GO:0036158	outer dynein arm assembly	-	IMP	11062149 11788826 15750039 16627867 18950741 22499950 23261302
GO:0060271	cilium assembly	-	IMP	16492982

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005874	microtubule	-	IEA	-
GO:0005930	axoneme	-	IDA	15750039 16492982 18950741 23849778 24203976 26387594 26909801
GO:0030286	dynein complex	-	IBA	21873635
GO:0036157	outer dynein arm	-	IBA	21873635
GO:0036157	outer dynein arm	-	IDA	16627867
GO:0036157	outer dynein arm	-	IMP	11062149 11788826 22499950
GO:0097729	9+2 motile cilium	-	IDA	26909801

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25134640	DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. (2014 Aug 20)	Lee JH	Respir Res