Gene info: ID 2071

Gene: ERCC3

GENE ID: 2071

Synonyms: BTF2|GTF2H|RAD25|TFIIH|TTD2|XPB

Description: ERCC excision repair 3, TFIIH core complex helicase subunit

Gene type: protein-coding

Location: 2q14.3

dbXrefs: Ensembl:ENSG00000163161 MIM:133510 Vega:OTTHUMG00000131530 UniprotKB:P19447

RefSeq: NG_007454.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.737e-1 (AD) 4.004e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
QRICH1	0.962
SUPT7L	0.956
PARP6	0.95
MMS19	0.95
HKR1	0.95
MICU1	0.949
POLR3E	0.949
HDAC3	0.948
SUGP2	0.947
VPS39	0.947

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.647
OR4F29	-0.609
MTRNR2L6	-0.376
MTRNR2L9	-0.368
MTRNR2L10	-0.35
LRAT	-0.311
TTLL10	-0.293
HEY2	-0.288
KLRB1	-0.288
EVC2	-0.286

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C582286	1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea	ERCC3 gene mutant form results in increased susceptibility to 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea	26208482
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ERCC3 mRNA"	22698814
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ERCC3 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in increased expression of ERCC3 mRNA	22230336
D001151	Arsenic	Arsenic results in decreased expression of ERCC3 mRNA	12569548
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of ERCC3 protein"	20855422
D001280	Atrazine	Atrazine results in decreased expression of ERCC3 mRNA	25929836
D001554	Benzene	Benzene affects the expression of ERCC3 mRNA	16188086
D001554	Benzene	ERCC3 SNP affects the susceptibility to Benzene	19773279
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ERCC3 mRNA	28461126
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ERCC3 mRNA	22228805
D004958	Estradiol	Estradiol affects the expression of ERCC3 mRNA	18214933
D004958	Estradiol	Estradiol results in decreased expression of ERCC3 mRNA	24349563
C044887	beta-methylcholine	beta-methylcholine affects the expression of ERCC3 mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of ERCC3 mRNA	19371625
C006780	bisphenol A	bisphenol A results in increased expression of ERCC3 mRNA	25181051
D000069286	Bortezomib	ERCC3 gene SNP results in increased susceptibility to Bortezomib	20864405
D002104	Cadmium	Cadmium results in decreased activity of ERCC3 protein	16677676
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ERCC3 mRNA	11958953
D019256	Cadmium Chloride	MT1 affects the reaction [Cadmium Chloride results in decreased expression of ERCC3 mRNA]	11958953
D019256	Cadmium Chloride	MT2 affects the reaction [Cadmium Chloride results in decreased expression of ERCC3 mRNA]	11958953
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ERCC3 mRNA	17602206
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ERCC3 mRNA	17361019\|2126653
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ERCC3 mRNA	17602206
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ERCC3 mRNA	18544905
D015025	Zearalenone	Zearalenone results in increased expression of ERCC3 mRNA	19371625
D005485	Flutamide	Flutamide results in increased expression of ERCC3 mRNA	24136188
D019833	Genistein	Genistein results in increased expression of ERCC3 mRNA	19371625
C071834	glycidamide	glycidamide affects the expression of ERCC3 protein	21978862
D048628	Ketolides	Ketolides analog results in increased expression of ERCC3 mRNA	24967691
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ERCC3 mRNA	18544905
D007854	Lead	Lead affects the expression of ERCC3 mRNA	28903495
C017461	lead nitrate	lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]	11891201
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of ERCC3 mRNA	20864626
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ERCC3 mRNA"	25620056
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of ERCC3 mRNA"	19371625
D052638	Particulate Matter	Particulate Matter results in decreased methylation of ERCC3 gene	28495853
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of ERCC3 mRNA	18486366
D010634	Phenobarbital	Phenobarbital affects the expression of ERCC3 mRNA	23091169
D010862	Pilocarpine	Pilocarpine results in increased expression of ERCC3 mRNA	17971868
D010936	Plant Extracts	Plant Extracts results in increased expression of ERCC3 mRNA	23557933
D011791	Quartz	Quartz results in decreased expression of ERCC3 mRNA	27917503
D011794	Quercetin	Quercetin results in increased expression of ERCC3 mRNA	25862958
C059514	resveratrol	resveratrol results in increased expression of ERCC3 mRNA	19371625
C547185	riccardin D	riccardin D results in decreased expression of ERCC3 mRNA	24069304
C009277	sodium arsenate	sodium arsenate results in decreased expression of ERCC3 mRNA	24349563
D018038	Sodium Selenite	Sodium Selenite results in increased expression of ERCC3 mRNA	18175754
D012999	Soman	Soman results in decreased expression of ERCC3 mRNA	19281266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ERCC3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ERCC3 promoter]	19654925
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of ERCC3 gene	27618143
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ERCC3 gene	25560391\|2849585
D014810	Vitamin E	Vitamin E results in increased expression of ERCC3 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	TAS	8663148
GO:0003684	damaged DNA binding	-	NAS	2167179
GO:0004003	ATP-dependent DNA helicase activity	-	IBA	21873635
GO:0004003	ATP-dependent DNA helicase activity	-	IEA	-
GO:0004386	helicase activity	-	TAS	-
GO:0004672	protein kinase activity	contributes_to	IDA	9852112
GO:0005515	protein binding	-	IPI	7663514 7926747 8652557 8692842 9173976 10734143 16669699 17438371 19172752 21988832 25416956 26496610 27193682
GO:0005524	ATP binding	-	IEA	-
GO:0008022	protein C-terminus binding	-	IPI	10801852 17466626
GO:0008094	DNA-dependent ATPase activity	contributes_to	IDA	9852112
GO:0008094	DNA-dependent ATPase activity	contributes_to	IMP	8663148
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0008134	transcription factor binding	-	IDA	9173976
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	CONTRIBUTES_TO	IBA	21873635
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	contributes_to	IDA	9852112
GO:0015616	DNA translocase activity	-	IBA	21873635
GO:0016887	ATPase activity	-	IDA	17466626
GO:0043138	3'-5' DNA helicase activity	-	IBA	21873635
GO:0043138	3'-5' DNA helicase activity	-	IDA	17466626
GO:0043138	3'-5' DNA helicase activity	-	IMP	8663148
GO:0047485	protein N-terminus binding	-	IPI	8652557

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000019	regulation of mitotic recombination	-	IBA	21873635
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	-	IBA	21873635
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	-	IMP	17466626
GO:0001111	promoter clearance from RNA polymerase II promoter	-	IBA	21873635
GO:0001113	transcriptional open complex formation at RNA polymerase II promoter	-	IBA	21873635
GO:0001666	response to hypoxia	-	IEA	-
GO:0006265	DNA topological change	-	IMP	8663148
GO:0006281	DNA repair	-	IMP	2167179
GO:0006283	transcription-coupled nucleotide-excision repair	-	IBA	21873635
GO:0006283	transcription-coupled nucleotide-excision repair	-	IDA	8663148
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006289	nucleotide-excision repair	-	IMP	17509950
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	-
GO:0006363	termination of RNA polymerase I transcription	-	TAS	-
GO:0006366	transcription by RNA polymerase II	-	IDA	9852112
GO:0006366	transcription by RNA polymerase II	-	IMP	8663148
GO:0006366	transcription by RNA polymerase II	-	TAS	-
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	-
GO:0006370	7-methylguanosine mRNA capping	-	TAS	-
GO:0006468	protein phosphorylation	-	IEA	-
GO:0006915	apoptotic process	-	IMP	8675009
GO:0006979	response to oxidative stress	-	IMP	17614221
GO:0008104	protein localization	-	IMP	17509950
GO:0009411	response to UV	-	IBA	21873635
GO:0009411	response to UV	-	IMP	17509950
GO:0009650	UV protection	-	IEA	-
GO:0010525	regulation of transposition, RNA-mediated	-	IBA	21873635
GO:0016032	viral process	-	IEA	-
GO:0033683	nucleotide-excision repair, DNA incision	-	IBA	21873635
GO:0033683	nucleotide-excision repair, DNA incision	-	IMP	8692841 17466626
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0035315	hair cell differentiation	-	IBA	21873635
GO:0035315	hair cell differentiation	-	IMP	11335038
GO:0043065	positive regulation of apoptotic process	-	IDA	16914395
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	8692841
GO:0048568	embryonic organ development	-	IBA	21873635
GO:0048568	embryonic organ development	-	IEA	-
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	-	IBA	21873635
GO:0070911	global genome nucleotide-excision repair	-	TAS	-
GO:1901990	regulation of mitotic cell cycle phase transition	-	IBA	21873635
GO:1901990	regulation of mitotic cell cycle phase transition	-	IMP	17088560
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000112	nucleotide-excision repair factor 3 complex	-	IBA	21873635
GO:0000439	core TFIIH complex	COLOCALIZES_WITH	IBA	21873635
GO:0000439	core TFIIH complex	-	IEA	-
GO:0005634	nucleus	-	TAS	8663148
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005669	transcription factor TFIID complex	-	IDA	27193682
GO:0005675	holo TFIIH complex	-	IBA	21873635
GO:0005675	holo TFIIH complex	-	IDA	8692842 9852112
GO:0005675	holo TFIIH complex	-	TAS	7663514
GO:0097550	transcriptional preinitiation complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa03420	Nucleotide excision repair

Reactome ID	Reactome Term	Evidence
R-HSA-112382	Formation of RNA Pol II elongation complex	TAS
R-HSA-113418	Formation of the Early Elongation Complex	TAS
R-HSA-162587	HIV Life Cycle	IEA
R-HSA-162599	Late Phase of HIV Life Cycle	IEA
R-HSA-162906	HIV Infection	IEA
R-HSA-1643685	Disease	IEA
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	IEA
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	IEA
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	IEA
R-HSA-167161	HIV Transcription Initiation	IEA
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	IEA
R-HSA-167169	HIV Transcription Elongation	IEA
R-HSA-167172	Transcription of the HIV genome	IEA
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	IEA
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	IEA
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5663205	Infectious disease	IEA
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-674695	RNA Polymerase II Pre-transcription Events	TAS
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	TAS
R-HSA-72086	mRNA Capping	TAS
R-HSA-73762	RNA Polymerase I Transcription Initiation	TAS
R-HSA-73772	RNA Polymerase I Promoter Escape	TAS
R-HSA-73776	RNA Polymerase II Promoter Escape	TAS
R-HSA-73777	RNA Polymerase I Chain Elongation	TAS
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	TAS
R-HSA-73854	RNA Polymerase I Promoter Clearance	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73863	RNA Polymerase I Transcription Termination	TAS
R-HSA-73864	RNA Polymerase I Transcription	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75953	RNA Polymerase II Transcription Initiation	TAS
R-HSA-75955	RNA Polymerase II Transcription Elongation	TAS
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	TAS
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24582975	Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. (2014 May 25)	Lu B	Gene
29528139	Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck. (2018 Jun)	Han P	Mol Carcinog
10910954	Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis. (2000 Aug)	Cheng L	Carcinogenesis
24020925	DNA repair gene polymorphisms and risk of head and neck cancer in the Tunisian population. (2014 Mar)	Khlifi R	J Oral Pathol Med
11900225	Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck. (2002 Jan 15)	Cheng L	Cancer
28379545	Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck. (2017 May 1)	Han P	Carcinogenesis
26617899	Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population. (2015)	Sun Y	Int J Clin Exp Pathol