Gene: JAG2

3714
HJ2|SER2
jagged 2
protein-coding
14q32.33
Ensembl:ENSG00000184916 MIM:602570 Vega:OTTHUMG00000140172 UniprotKB:Q9Y219
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.394e-1 (AD)  5.798e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15421321chr14:105618816JAG28.400e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC29A10.86
MICAL10.857
ARRDC10.856
ITGA30.851
OSBPL50.845
RASGRP20.844
CHRD0.844
IFFO10.84
ADCY60.839
AGRN0.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.482
OR4F29-0.476
LRAT-0.386
PHEX-0.379
AKR1C3-0.363
FGF2-0.36
ZFHX4-AS1-0.344
DIAPH3-0.339
NXT2-0.335
BBOX1-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of JAG2 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of JAG2 mRNA"19162173
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of JAG2 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of JAG2 mRNA"19114083
D000643Ammonium ChlorideAmmonium Chloride affects the expression of JAG2 mRNA16483693
D001151ArsenicArsenic affects the methylation of JAG2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of JAG2 mRNA23497375
C015001arsenitearsenite results in increased expression of JAG2 mRNA18191166
D001507BeclomethasoneBeclomethasone results in increased expression of JAG2 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of JAG2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAG2 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JAG2 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of JAG2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of JAG2 mRNA22576693
C006780bisphenol Abisphenol A results in decreased expression of JAG2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased methylation of JAG2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of JAG2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of JAG2 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in increased expression of JAG2 protein25118938
D019256Cadmium ChlorideJAG2 mutant form inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]25118938
D019256Cadmium ChlorideJAG2 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]25118938
C018021cobaltous chloridecobaltous chloride results in decreased expression of JAG2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of JAG2 mRNA19376846
D003042CocaineCocaine affects the expression of JAG2 mRNA20187946
D003300Copper[Disulfiram binds to Copper] which results in increased expression of JAG2 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of JAG2 mRNA20971185
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of JAG2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of JAG2 mRNA27392435
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of JAG2 mRNA21858171
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of JAG2 mRNA28085963
D002117CalcitriolCalcitriol results in decreased expression of JAG2 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of JAG2 mRNA26485663
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of JAG2 mRNA24690739
D004317DoxorubicinDoxorubicin results in decreased expression of JAG2 mRNA16404146
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of JAG2 mRNA17606305
C069837fullerene C60fullerene C60 results in increased expression of JAG2 mRNA19167457
D017313FenretinideFenretinide results in increased expression of JAG2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of JAG2 mRNA27392435
D007649KetamineKetamine results in decreased expression of JAG2 mRNA20080153
C500085muraglitazarmuraglitazar results in decreased expression of JAG2 mRNA21515302
D009532NickelNickel affects the expression of JAG2 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of JAG2 mRNA]14575637
C028007nickel monoxidenickel monoxide results in increased expression of JAG2 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of JAG2 mRNA20971185
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of JAG2 mRNA23602845
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of JAG2 mRNA22039516
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of JAG2 mRNA21858171
C089730rosiglitazonerosiglitazone results in decreased expression of JAG2 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of JAG2 mRNA25895662
D012906SmokeSmoke results in decreased expression of JAG2 mRNA21095227
C025462sulindac sulfidesulindac sulfide results in increased expression of JAG2 mRNA16184548
C501413tesaglitazartesaglitazar results in decreased expression of JAG2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of JAG2 mRNA27913140
D013853ThioacetamideThioacetamide affects the methylation of JAG2 promoter25151969
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of JAG2 mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of JAG2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of JAG2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of JAG2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of JAG2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of JAG2 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of JAG2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of JAG2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of JAG2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IPI9315665  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16713569  
GO:0008083growth factor activity-IDA10383933  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0003016respiratory system process-IEA-  
GO:0007219Notch signaling pathway-NAS11056013  
GO:0007219Notch signaling pathway-TAS-  
GO:0007283spermatogenesis-IEP11700865  
GO:0009912auditory receptor cell fate commitment-ISS10080181  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016331morphogenesis of embryonic epithelium-IEA-  
GO:0030154cell differentiation-IDA11700865  
GO:0030155regulation of cell adhesion-IEA-  
GO:0030217T cell differentiation-IDA10383933  
GO:0042127regulation of cell proliferation-IDA10383933  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0042492gamma-delta T cell differentiation-IEA-  
GO:0045061thymic T cell selection-IDA10383933  
GO:0045747positive regulation of Notch signaling pathway-ISS-  
GO:1990134epithelial cell apoptotic process involved in palatal shelf morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS10910909  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-1980150Signaling by NOTCH4TAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusTAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2660825Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2660826Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in CancerTAS
R-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One