Gene: KCNJ9

3765
GIRK3|KIR3.3
potassium voltage-gated channel subfamily J member 9
protein-coding
1q23.2
Ensembl:ENSG00000162728 MIM:600932 Vega:OTTHUMG00000024072 UniprotKB:Q92806
NC_000001.11
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.105e-1 (AD)  5.669e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAZ0.934
DCTN10.933
GAS70.925
KLC10.914
BCL2L20.901
FAM219A0.899
IGSF80.899
AK50.89
FAM131B0.889
VAPB0.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.557
OR4F5-0.513
RNF135-0.488
GJB2-0.469
LRAT-0.451
EVC2-0.45
RREB1-0.447
STK17B-0.447
DMRTA1-0.446
TGIF1-0.446

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB11633IsavuconazoleSmall Molecule241479-67-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNJ9 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNJ9 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of KCNJ9 mRNA25181051
D003300CopperCopper deficiency results in increased expression of KCNJ9 mRNA26033743
D016572CyclosporineCyclosporine results in increased methylation of KCNJ9 promoter27989131
C017160cypermethrincypermethrin results in decreased expression of KCNJ9 mRNA22528246
D019422Dietary SucroseDietary Sucrose results in increased expression of KCNJ9 mRNA26033743
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of KCNJ9 gene23968726
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of KCNJ9 mRNA12655031
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KCNJ9 protein23301498
D007657Ketone BodiesKetone Bodies results in decreased expression of KCNJ9 mRNA15469884
D007854LeadLead affects the expression of KCNJ9 mRNA28903495
D008694MethamphetamineMethamphetamine results in decreased expression of KCNJ9 mRNA21886566
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of KCNJ9 gene23968726
C006253pirinixic acidpirinixic acid results in decreased expression of KCNJ9 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of KCNJ9 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNJ9 mRNA24680724
D014635Valproic AcidValproic Acid results in decreased methylation of KCNJ9 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KCNJ9 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005242inward rectifier potassium channel activity-IBA21873635  
GO:0005515protein binding-IPI12297500  
GO:0015467G-protein activated inward rectifier potassium channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010107potassium ion import-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1296041Activation of G protein gated Potassium channelsTAS
R-HSA-1296059G protein gated Potassium channelsTAS
R-HSA-1296065Inwardly rectifying K+ channelsTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977444GABA B receptor activationTAS
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23134054Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models. (2012)Buck KJAlcohol Res
29058377Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. (2017 Oct 23)Sanchez-Roige SAddict Biol
19759313Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. (2009 Sep 16)Kozell LBJ Neurosci