Gene: ZSWIM5

57643
-
zinc finger SWIM-type containing 5
protein-coding
1p34.1
Ensembl:ENSG00000162415 Vega:OTTHUMG00000008950 UniprotKB:Q9P217
NC_000001.11
SNP Mapped
3   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.397e-1 (AD)  9.028e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1938300chr1:45207111 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs11211074chr1:45064837 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs3850855chr1:45058221 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC930.848
ZNF7930.845
ZNF5870.843
ZNF3180.839
NFATC2IP0.837
CHD80.836
GON4L0.834
GTF3C20.833
TMEM1310.832
LDB10.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.492
OR4F29-0.443
ANXA13-0.272
KLRC2-0.251
EIF4EBP1-0.238
GSC-0.237
SNHG18-0.237
ROM1-0.235
S100A1-0.225
LBP-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSWIM5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSWIM5 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZSWIM5 mRNA26001963
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of ZSWIM5 mRNA20404318
C006780bisphenol Abisphenol A affects the expression of ZSWIM5 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZSWIM5 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZSWIM5 mRNA20938992
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of ZSWIM5 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of ZSWIM5 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZSWIM5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ZSWIM5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ZSWIM5 mRNA22023808
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of ZSWIM5 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of ZSWIM5 mRNA26033743
C118739entinostatentinostat results in decreased expression of ZSWIM5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSWIM5 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZSWIM5 mRNA20938992
D005839GentamicinsGentamicins results in decreased expression of ZSWIM5 mRNA22061828
D017313FenretinideFenretinide results in increased expression of ZSWIM5 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZSWIM5 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZSWIM5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ZSWIM5 mRNA24796395
D007649KetamineKetamine results in decreased expression of ZSWIM5 mRNA20080153
D008558MelphalanMelphalan results in decreased expression of ZSWIM5 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ZSWIM5 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZSWIM5 mRNA28001369
C046012pentanalpentanal results in decreased expression of ZSWIM5 mRNA26079696
D011192Potassium DichromatePotassium Dichromate results in increased expression of ZSWIM5 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of ZSWIM5 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ZSWIM5 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ZSWIM5 mRNA25895662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ZSWIM5 mRNA25613284
C011559tributyltintributyltin results in decreased expression of ZSWIM5 mRNA27614199
C012589trichostatin Atrichostatin A results in decreased expression of ZSWIM5 mRNA24935251
D014520UrethaneUrethane results in increased expression of ZSWIM5 mRNA28818685
C025643vinclozolinvinclozolin results in decreased expression of ZSWIM5 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of ZSWIM5 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:1902667regulation of axon guidance-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0031462Cul2-RING ubiquitin ligase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal