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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for CETP |
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Phenotypic Information for CETP(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: CETP |
Familial Cancer Database: CETP |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS REACTOME_LIPOPROTEIN_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: CETP |
MedGen: CETP (Human Medical Genetics with Condition) | |
ClinVar: CETP | |
Phenotype | MGI: CETP (International Mouse Phenotyping Consortium) |
PhenomicDB: CETP |
Mutations for CETP |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CETP related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   | |||
GAIN (# sample) | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=42) | (# total SNVs=13) |
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(# total SNVs=2) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr16:57017553-57017553 | p.V486A | 3 |
chr16:57003556-57003556 | p.I134I | 3 |
chr16:57012109-57012109 | p.V363A | 3 |
chr16:56996995-56996995 | p.K64K | 2 |
chr16:57003319-57003319 | p.S85S | 2 |
chr16:57017290-57017290 | p.F458F | 2 |
chr16:56995952-56995952 | p.G21S | 2 |
chr16:57003551-57003551 | p.E133K | 1 |
chr16:57007404-57007404 | p.L304L | 1 |
chr16:57004986-57004986 | p.F190Y | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 |   | 12 | 2 |   | 4 |   |   |   |   | 6 |   |   |   |   | 9 | 4 | 1 | 6 |
# mutation | 1 | 1 |   | 11 | 2 |   | 4 |   |   |   |   | 6 |   |   |   |   | 14 | 4 | 1 | 6 |
nonsynonymous SNV | 1 | 1 |   | 8 | 1 |   | 2 |   |   |   |   | 4 |   |   |   |   | 6 | 3 |   | 5 |
synonymous SNV |   |   |   | 3 | 1 |   | 2 |   |   |   |   | 2 |   |   |   |   | 8 | 1 | 1 | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr16:57012109 | p.V303A,CETP | 3 |
chr16:57015105 | p.K334N,CETP | 2 |
chr16:57003556 | p.I134I,CETP | 2 |
chr16:57004978 | p.G21G,CETP | 1 |
chr16:57007305 | p.F184L,CETP | 1 |
chr16:57003370 | p.E263D,CETP | 1 |
chr16:57015098 | p.E422K,CETP | 1 |
chr16:57004989 | p.L37L,CETP | 1 |
chr16:57007351 | p.F187F,CETP | 1 |
chr16:57003380 | p.S274R,CETP | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for CETP |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ACVRL1,MILR1,C1orf54,CD209,CD248,CETP,CLEC4G, CYGB,DNASE1L3,EMP3,FOLR2,GMFG,GRAP,NCF4, POPDC2,PSTPIP1,PTGDS,SH2D3C,STAB1,TNFAIP8L2,WAS | CCL18,CEACAM3,CETP,CTSL,FBN1,GAD2,GAP43, HMOX1,LGI2,OR2AG1,OR8D1,RHOXF2B,SLC48A1,SNORA19, SPATA8,SPRR2F,TECTB,TMEM150B,VENTXP1,WNT10B,WNT1 | ||||
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ADCY4,AFAP1L1,ALPK2,ARHGEF15,CCDC102B,CD34,CETP, CHST1,CLEC1A,CUBN,CXorf36,ELTD1,FBLN7,FLI1, GIPC3,GPR116,NOTCH4,PCDH12,SH2D3C,STK32B,USHBP1 | ARHGAP25,BTN2A2,C1orf228,CETP,CMTM7,CR1,FUT7, FXYD5,GPSM3,GRHL3,HLA-DOA,HVCN1,KCNAB2,LOC283999, LTF,NKX6-3,OPRL1,SERPINB7,TCN1,ZBED2,ZBTB32 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for CETP |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01095 | cholesteryl ester transfer protein, plasma | approved | Fluvastatin | ![]() | ![]() |
DB01076 | cholesteryl ester transfer protein, plasma | approved | Atorvastatin | ![]() | ![]() |
DB00175 | cholesteryl ester transfer protein, plasma | approved | Pravastatin | ![]() | ![]() |
DB00264 | cholesteryl ester transfer protein, plasma | approved; investigational | Metoprolol | ![]() | ![]() |
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Cross referenced IDs for CETP |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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