Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for AMY2A

Basic gene info.	Gene symbol	AMY2A
	Gene name	amylase, alpha 2A (pancreatic)
	Synonyms	AMY2\|AMY2B\|PA
	Cytomap	UCSC genome browser: 1p21
	Genomic location	chr1 :104159998-104168400
	Type of gene	protein-coding
	RefGenes	NM_000699.2,
	Ensembl id	ENSG00000243480
	Description	1,4-alpha-D-glucan glucanohydrolasealpha-amylaseamylase, pancreatic, alpha-2Afound in the pancreasglycogenasepancreatic alpha-amylasepancreatic amylase 2Apancreatic amylase alpha 2A
	Modification date	20141207
dbXrefs	MIM : 104650
	HGNC : HGNC
	Ensembl : ENSG00000243480
	HPRD : 00094
	Vega : OTTHUMG00000011023
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_AMY2A
	BioGPS: 279
	Gene Expression Atlas: ENSG00000243480
	The Human Protein Atlas: ENSG00000243480
Pathway	NCI Pathway Interaction Database: AMY2A
	KEGG: AMY2A
	REACTOME: AMY2A
	ConsensusPathDB
	Pathway Commons: AMY2A
Metabolism	MetaCyc: AMY2A
	HUMANCyc: AMY2A
Regulation	Ensembl's Regulation: ENSG00000243480
	miRBase: chr1 :104,159,998-104,168,400
	TargetScan: NM_000699
	cisRED: ENSG00000243480
Context	iHOP: AMY2A
	cancer metabolism search in PubMed: AMY2A
	UCL Cancer Institute: AMY2A
Assigned class in ccmGDB	C

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Phenotypic Information for AMY2A(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: AMY2A
	Familial Cancer Database: AMY2A

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_STARCH_AND_SUCROSE_METABOLISM REACTOME_METABOLISM_OF_CARBOHYDRATES

Others
OMIM
Orphanet
Disease	KEGG Disease: AMY2A
	MedGen: AMY2A (Human Medical Genetics with Condition)
	ClinVar: AMY2A
Phenotype	MGI: AMY2A (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: AMY2A

Mutations for AMY2A

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AMY2A related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=33)	Stat. for Synonymous SNVs (# total SNVs=5)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:104166496-104166496	p.N370N	3
chr1:104160591-104160591	p.E62*	2
chr1:104160220-104160220	p.G53E	2
chr1:104166590-104166590	p.R402*	2
chr1:104160136-104160136	p.R25P	2
chr1:104160586-104160586	p.P60L	1
chr1:104162220-104162220	p.E186D	1
chr1:104160191-104160191	p.C43C	1
chr1:104163236-104163236	p.E270*	1
chr1:104162248-104162248	p.E196K	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	1	1	3			2					4		1			5	3	1	6
# mutation	1	1	1	3			2					6		1			5	3	1	6
nonsynonymous SNV	1	1	1	3			2					6		1			4	3	1	4
synonymous SNV																	1			2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:104160673	p.G89E	2
chr1:104161613	p.P59Q	1
chr1:104160223	p.V249G	1
chr1:104162220	p.E62K	1
chr1:104160582	p.E255E	1
chr1:104162265	p.P69H	1
chr1:104160583	p.G435V	1
chr1:104162281	p.E75K	1
chr1:104160098	p.P79A	1
chr1:104160591	p.V80F	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for AMY2A in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AMY2A

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACTRT1,ADCYAP1,AMY2A,ATG9B,LINC00470___CHMP1B,TSPEAR,C6orf58, CPLX1,DDX25,EPHA8,FSHB,INSM1,KRTAP12-1,LINC01512, NHEG1,NMNAT2,PCSK1,PDZRN4,PRLHR,SIAH3,SLC35D3	AMY2A,AMY2B,TEX43,SAPCD1,CCDC84,CDK3,CRYGS, CYP2D6,DFNB59,KLKB1,LMBR1L,LOC100272146,LOC284440,LUC7L, LYG1,PRSS50,RETNLB,SLC23A3,TCP10,TMEM31,U2AF1L4

AMY2A,C11orf40,CELA2A,CELA2B,CELA3A,CELA3B,CLPS, CPA1,CPB1,CTRB1,CTRB2,CTRC,CYP2W1,MAGIX, OPRM1,PLA2G1B,PNLIP,PNLIPRP1,PSG8,SERPINI2,SYCN	AMY2A,ANKS6,C3orf62,CRTC2,CSAD,FAM156A,FAM193B, FLJ34503,GHR,GOLGA8A,HERC2P2,KAAG1,KCTD19,KLHL17, KSR2,LENG8,QRICH2,RGL3,STX16,TMEM80,TTLL3

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AMY2A

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00284	amylase, alpha 2A (pancreatic)	approved; investigational	Acarbose
DB01922	amylase, alpha 2A (pancreatic)	experimental	Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam
DB02218	amylase, alpha 2A (pancreatic)	experimental	N-[4-Hydroxymethyl-Cyclohexan-6-Yl-1,2,3-Triol]-4,6-Dideoxy-4-Aminoglucopyranoside
DB02379	amylase, alpha 2A (pancreatic)	experimental	Beta-D-Glucose
DB02889	amylase, alpha 2A (pancreatic)	experimental	4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose
DB03088	amylase, alpha 2A (pancreatic)	experimental	Pyroglutamic Acid
DB03092	amylase, alpha 2A (pancreatic)	experimental	5-Hydroxymethyl-Chonduritol
DB03439	amylase, alpha 2A (pancreatic)	experimental	4,6-Dideoxy-4-Amino-Alpha-D-Glucose
DB03495	amylase, alpha 2A (pancreatic)	experimental	4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose
DB03773	amylase, alpha 2A (pancreatic)	experimental	6-Deoxy-Alpha-D-Glucose
DB03971	amylase, alpha 2A (pancreatic)	experimental	Acarbose Derived Hexasaccharide
DB04453	amylase, alpha 2A (pancreatic)	experimental	4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose
DB04618	amylase, alpha 2A (pancreatic)	experimental	4,6-DIDEOXY-4-{[4-[(4-O-HEXOPYRANOSYLHEXOPYRANOSYL)OXY]-5,6-DIHYDROXY-3-(HYDROXYMETHYL)CYCLOHEX-2-EN-1-YL]AMINO}HEXOPYRANOSYL-(1->4)HEXOPYRANOSYL-(1->4)HEXOPYRANOSE
DB04465	amylase, alpha 2A (pancreatic)	experimental	Lactose

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Cross referenced IDs for AMY2A

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information