Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GSTA1
Basic gene info.Gene symbolGSTA1
Gene nameglutathione S-transferase alpha 1
SynonymsGST2|GSTA1-1|GTH1
CytomapUCSC genome browser: 6p12.1
Genomic locationchr6 :52656177-52668664
Type of geneprotein-coding
RefGenesNM_145740.3,
Ensembl idENSG00000243955
DescriptionGST HA subunit 1GST class-alpha member 1GST, class alpha, 1GST-epsilonS-(hydroxyalkyl)glutathione lyase A1glutathione S-alkyltransferase A1glutathione S-aryltransferase A1glutathione S-transferase 2glutathione S-transferase A1glutathione S-transf
Modification date20141222
dbXrefs MIM : 138359
HGNC : HGNC
HPRD : 00708
ProteinUniProt: P08263
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTA1
BioGPS: 2938
Gene Expression Atlas: ENSG00000243955
The Human Protein Atlas: ENSG00000243955
PathwayNCI Pathway Interaction Database: GSTA1
KEGG: GSTA1
REACTOME: GSTA1
ConsensusPathDB
Pathway Commons: GSTA1
MetabolismMetaCyc: GSTA1
HUMANCyc: GSTA1
RegulationEnsembl's Regulation: ENSG00000243955
miRBase: chr6 :52,656,177-52,668,664
TargetScan: NM_145740
cisRED: ENSG00000243955
ContextiHOP: GSTA1
cancer metabolism search in PubMed: GSTA1
UCL Cancer Institute: GSTA1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of GSTA1 in cancer cell metabolism1. Yager JD (2015) Mechanisms of estrogen carcinogenesis: The role of E2/E1-quinone metabolites suggests new approaches to preventive intervention - A review. Steroids 99: 56-60. doi: 10.1016/j.steroids.2014.08.006. pmid: 4339663. go to article
2. Marquardt JU, Seo D, Gomez-Quiroz LE, Uchida K, Gillen MC, et al. (2012) Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways. Biochim Biophys Acta 1822: 942-951. doi: 10.1016/j.bbadis.2012.02.012. pmid: 3338880. go to article

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Phenotypic Information for GSTA1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GSTA1
Familial Cancer Database: GSTA1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLUTATHIONE_METABOLISM
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_CYTOCHROME_P450

check002.gifOthers
OMIM 138359; gene.
Orphanet
DiseaseKEGG Disease: GSTA1
MedGen: GSTA1 (Human Medical Genetics with Condition)
ClinVar: GSTA1
PhenotypeMGI: GSTA1 (International Mouse Phenotyping Consortium)
PhenomicDB: GSTA1

Mutations for GSTA1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTA1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AL096729GSTA12186065266305952664916ZNF54818602394195791338157913914

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=35)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr6:52656682-52656682p.E215K2
chr6:52659012-52659012p.L109L2
chr6:52657666-52657666p.F178F2
chr6:52657738-52657738p.S154R2
chr6:52658962-52658962p.K125K2
chr6:52657768-52657768p.G144G1
chr6:52656675-52656675p.R217K1
chr6:52658988-52658988p.K117Q1
chr6:52657701-52657701p.V167I1
chr6:52661025-52661025p.A76V1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11 72 2  1 541  62 2
# mutation11 72 2  1 541  62 2
nonsynonymous SNV11 52 2  1 421  42 2
synonymous SNV   2       12   2   
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr6:52659012p.L109L2
chr6:52657738p.S154R2
chr6:52656747p.V167G1
chr6:52657768p.P110P1
chr6:52659018p.V167I1
chr6:52656749p.Y166Y1
chr6:52657770p.L107V1
chr6:52659022p.M105I1
chr6:52657657p.N80S1
chr6:52658943p.N151D1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GSTA1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GSTA1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AADAC,C1orf141,FOXL2NB,MGARP,CYP11A1,CYP17A1,CYP19A1,
FSHR,GSTA1,HSD3B1,INHA,INSL3,KLHL4,LHCGR,
LRGUK,MBOAT4,MRO,SCARB1,STAR,TCF21,TREML5P
AK5,ALOX5,BBOX1,NCMAP,CTSV,CXCL16,GSTA1,
GSTA2,KLK5,LCMT2,LRRC4C,RARRES1,SLC34A2,STAC2,
SUSD4,TACSTD2,TTC9,VGLL1,VWA5A,WFDC2,WNT7B

AMPH,ARR3,CDH4,CNGA3,CYLC1,ELOVL2,FAM181B,
FOXC2,GAD2,GSTA1,MYCN,MYCNOS,NNAT,P2RY4,
PON1,SCARNA20,SERPINA12,SYNGR4,UGT2B11,UGT2B28,ZNF385B
AADAC,ABCG5,ABCG8,AGXT2,APOA1,APOA4,APOC3,
C17orf78,CRISP1,FABP6,GSTA1,GSTA2,GSTA5,ONECUT3,
RBP2,SLC2A2,SPA
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GSTA1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P08263; -.
ChemistryChEMBL CHEMBL3409; -.
Organism-specific databasesPharmGKB PA29016; -.
Organism-specific databasesCTD 2938; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00143glutathione S-transferase alpha 1approved; nutraceuticalGlutathione
DB01915glutathione S-transferase alpha 1experimentalS-Hydroxycysteine
DB02486glutathione S-transferase alpha 1experimental2-Hydroxyethyl Disulfide
DB02943glutathione S-transferase alpha 1experimentalN-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine
DB03003glutathione S-transferase alpha 1experimentalGlutathione Sulfonic Acid
DB03602glutathione S-transferase alpha 1experimentalS-Benzyl-Glutathione
DB04132glutathione S-transferase alpha 1experimentalS-Hexylglutathione
DB04572glutathione S-transferase alpha 1approvedThiotepa
DB00682glutathione S-transferase alpha 1approvedWarfarin
DB00993glutathione S-transferase alpha 1approvedAzathioprine
DB01033glutathione S-transferase alpha 1approvedMercaptopurine
DB00515glutathione S-transferase alpha 1approvedCisplatin
DB00291glutathione S-transferase alpha 1approvedChlorambucil
DB00997glutathione S-transferase alpha 1approved; investigationalDoxorubicin
DB00773glutathione S-transferase alpha 1approvedEtoposide
DB01204glutathione S-transferase alpha 1approved; investigationalMitoxantrone
DB00541glutathione S-transferase alpha 1approved; investigationalVincristine
DB00531glutathione S-transferase alpha 1approved; investigationalCyclophosphamide
DB01008glutathione S-transferase alpha 1approved; investigationalBusulfan
DB01101glutathione S-transferase alpha 1approved; investigationalCapecitabine
DB00762glutathione S-transferase alpha 1approved; investigationalIrinotecan
DB00526glutathione S-transferase alpha 1approved; investigationalOxaliplatin
DB01026glutathione S-transferase alpha 1approved; investigationalKetoconazole
DB01110glutathione S-transferase alpha 1approved; investigationalMiconazole


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Cross referenced IDs for GSTA1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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