Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MAOA
Basic gene info.Gene symbolMAOA
Gene namemonoamine oxidase A
SynonymsMAO-A
CytomapUCSC genome browser: Xp11.3
Genomic locationchrX :43515408-43606068
Type of geneprotein-coding
RefGenesNM_000240.3,
NM_001270458.1,
Ensembl idENSG00000189221
Descriptionamine oxidase [flavin-containing] Amonoamine oxidase type A
Modification date20141222
dbXrefs MIM : 309850
HGNC : HGNC
Ensembl : ENSG00000189221
HPRD : 02400
ProteinUniProt: P21397
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAOA
BioGPS: 4128
Gene Expression Atlas: ENSG00000189221
The Human Protein Atlas: ENSG00000189221
PathwayNCI Pathway Interaction Database: MAOA
KEGG: MAOA
REACTOME: MAOA
ConsensusPathDB
Pathway Commons: MAOA
MetabolismMetaCyc: MAOA
HUMANCyc: MAOA
RegulationEnsembl's Regulation: ENSG00000189221
miRBase: chrX :43,515,408-43,606,068
TargetScan: NM_000240
cisRED: ENSG00000189221
ContextiHOP: MAOA
cancer metabolism search in PubMed: MAOA
UCL Cancer Institute: MAOA
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of MAOA in cancer cell metabolism1. Flamand V, Zhao H, Peehl DM (2010) Targeting monoamine oxidase A in advanced prostate cancer. J Cancer Res Clin Oncol 136: 1761-1771. doi: 10.1007/s00432-010-0835-6. pmid: 2945406. go to article
2. Wu JB, Shao C, Li X, Li Q, Hu P, et al. (2014) Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest 124: 2891-2908. doi: 10.1172/JCI70982. pmid: 4071401. go to article

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Phenotypic Information for MAOA(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MAOA
Familial Cancer Database: MAOA
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM
KEGG_ARGININE_AND_PROLINE_METABOLISM
KEGG_HISTIDINE_METABOLISM
KEGG_TYROSINE_METABOLISM
KEGG_PHENYLALANINE_METABOLISM
KEGG_TRYPTOPHAN_METABOLISM
KEGG_DRUG_METABOLISM_CYTOCHROME_P450

check002.gifOthers
OMIM 300615; phenotype.
309850; gene+phenotype.
Orphanet 3057; Monoamine oxidase A deficiency.
DiseaseKEGG Disease: MAOA
MedGen: MAOA (Human Medical Genetics with Condition)
ClinVar: MAOA
PhenotypeMGI: MAOA (International Mouse Phenotyping Consortium)
PhenomicDB: MAOA

Mutations for MAOA
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAOA related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CB242049MAOA17153X4360592843606064MAOA149207X4360575143605809
BF803193MAOA15235X4360122743603397ACTB229334755679115568016
BG995293MAOA1268X4357942743579695ZFPM1262351168857823788578326

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=35)
Stat. for Synonymous SNVs
(# total SNVs=7)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=3)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr23:43515648-43515648p.G20E2
chr23:43571993-43571993p.K151N2
chr23:43571137-43571137p.R109W2
chr23:43572006-43572006p.T156S2
chr23:43601277-43601277p.I415M2
chr23:43515634-43515634p.D15E2
chr23:43571169-43571169p.I119I1
chr23:43603045-43603046p.R424fs*271
chr23:43587477-43587477p.H187Q1
chr23:43603693-43603693p.G506A1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11171   21 5   131 8
# mutation11161   21 5   131 8
nonsynonymous SNV11151   11 5    21 5
synonymous SNV   1    1      11  3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chrX:43572006p.T156S,MAOA2
chrX:43572004p.V17L1
chrX:43592026p.Q237R,MAOA1
chrX:43515638p.G20E1
chrX:43599971p.I254V,MAOA1
chrX:43515648p.R47K1
chrX:43572023p.K267T,MAOA1
chrX:43601277p.G103E1
chrX:43542827p.D328Y,MAOA1
chrX:43587477p.P114T1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MAOA in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MAOA

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACADSB,LINC00238,CDS2,CFD,CYB5D2,CYP2A6,DAND5,
DBNDD2,FAM107B,GRIK1,IQSEC2,LOC642597,MAOA,NPY,
PIGT,PNPLA4,PRR23B,PRR23C,SLC1A2,SLC5A8,SOX2-OT
ADH1B,ADH5,ANTXR2,BNIP3L,FAM213A,PQLC2L,CIDEC,
EIF4EBP2,FAM89A,FBXO27,GHR,GNAI1,LOC283392,LOC401052,
MAOA,PLA2G16,PRDX6,RHOBTB3,SLC19A3,TMEM132C,TYRO3

ADH6,AHCYL1,ALDH6A1,AP3S2,APOBEC4,ATPAF1,C1orf210,
C9orf152,CEACAM16,CPT2,CYP2J2,FAM120A,FAR2,GPA33,
MAOA,NR3C2,PHLPP2,PPARA,RBM47,SLC9A2,TMEM170A
AKR7L,SOWAHA,CES2,CHN2,CYP2J2,CYP4F12,DDC,
DEGS2,DRD4,EPHX2,ING2,INPP5J,IYD,MAOA,
MARC2,MYO1A,PCK2,RALGPS1,SLC37A4,SLC39A5,ZNF664
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MAOA
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P21397; -.
ChemistryChEMBL CHEMBL1951; -.
ChemistryGuidetoPHARMACOLOGY 2489; -.
Organism-specific databasesPharmGKB PA236; -.
Organism-specific databasesCTD 4128; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00191monoamine oxidase Aillicit; approvedPhentermine
DB00752monoamine oxidase AapprovedTranylcypromine
DB00780monoamine oxidase AapprovedPhenelzine
DB00805monoamine oxidase AapprovedMinaprine
DB00909monoamine oxidase Aapproved; investigationalZonisamide
DB01037monoamine oxidase Aapproved; investigationalSelegiline
DB01171monoamine oxidase AapprovedMoclobemide
DB01247monoamine oxidase AapprovedIsocarboxazid
DB01442monoamine oxidase Aillicit; experimentalMMDA
DB01472monoamine oxidase Aillicit; experimental4-Methoxyamphetamine
DB01577monoamine oxidase Aillicit; approvedMethamphetamine
DB01626monoamine oxidase AapprovedPargyline
DB03147monoamine oxidase AexperimentalFlavin-Adenine Dinucleotide
DB04017monoamine oxidase AexperimentalN-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine
DB04820monoamine oxidase AwithdrawnNialamide
DB04821monoamine oxidase AwithdrawnNomifensine
DB04832monoamine oxidase AwithdrawnZimelidine
DB07641monoamine oxidase AexperimentalDECYL(DIMETHYL)PHOSPHINE OXIDE
DB07919monoamine oxidase Aexperimental7-METHOXY-1-METHYL-9H-BETA-CARBOLINE
DB00215monoamine oxidase AapprovedCitalopram
DB00176monoamine oxidase Aapproved; investigationalFluvoxamine
DB00715monoamine oxidase Aapproved; investigationalParoxetine
DB01104monoamine oxidase AapprovedSertraline
DB00184monoamine oxidase AapprovedNicotine
DB00988monoamine oxidase AapprovedDopamine
DB00368monoamine oxidase AapprovedNorepinephrine
DB00126monoamine oxidase Aapproved; nutraceuticalVitamin C
DB00472monoamine oxidase AapprovedFluoxetine
DB00734monoamine oxidase Aapproved; investigationalRisperidone


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Cross referenced IDs for MAOA
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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