Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MAOB
Basic gene info.Gene symbolMAOB
Gene namemonoamine oxidase B
Synonyms-
CytomapUCSC genome browser: Xp11.23
Genomic locationchrX :43625856-43741721
Type of geneprotein-coding
RefGenesNM_000898.4,
Ensembl idENSG00000069535
DescriptionMAO, brainMAO, plateletMAO-Badrenalin oxidaseamine oxidase [flavin-containing] Bmonoamine oxidase type Btyramine oxidase
Modification date20141207
dbXrefs MIM : 309860
HGNC : HGNC
Ensembl : ENSG00000069535
HPRD : 02401
Vega : OTTHUMG00000021388
ProteinUniProt: P27338
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAOB
BioGPS: 4129
Gene Expression Atlas: ENSG00000069535
The Human Protein Atlas: ENSG00000069535
PathwayNCI Pathway Interaction Database: MAOB
KEGG: MAOB
REACTOME: MAOB
ConsensusPathDB
Pathway Commons: MAOB
MetabolismMetaCyc: MAOB
HUMANCyc: MAOB
RegulationEnsembl's Regulation: ENSG00000069535
miRBase: chrX :43,625,856-43,741,721
TargetScan: NM_000898
cisRED: ENSG00000069535
ContextiHOP: MAOB
cancer metabolism search in PubMed: MAOB
UCL Cancer Institute: MAOB
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for MAOB(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MAOB
Familial Cancer Database: MAOB
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM
KEGG_ARGININE_AND_PROLINE_METABOLISM
KEGG_HISTIDINE_METABOLISM
KEGG_TYROSINE_METABOLISM
KEGG_PHENYLALANINE_METABOLISM
KEGG_TRYPTOPHAN_METABOLISM
KEGG_DRUG_METABOLISM_CYTOCHROME_P450

check002.gifOthers
OMIM 309860; gene.
Orphanet
DiseaseKEGG Disease: MAOB
MedGen: MAOB (Human Medical Genetics with Condition)
ClinVar: MAOB
PhenotypeMGI: MAOB (International Mouse Phenotyping Consortium)
PhenomicDB: MAOB

Mutations for MAOB
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAOB related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AW794716AAAS26324125370136353701914MAOB316496X4362625243626432

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=35)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr23:43652774-43652774p.F274L4
chr23:43652797-43652797p.P266L3
chr23:43639593-43639593p.E359K2
chr23:43662570-43662570p.T121A2
chr23:43662605-43662605p.P109L2
chr23:43656441-43656441p.L183L2
chr23:43655067-43655067p.V229V2
chr23:43637938-43637938p.E376D2
chr23:43652716-43652716p.S293L1
chr23:43662652-43662652p.?1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 1 92 2 11 2 1  61 9
# mutation 1 72 2 11 2 1  81 11
nonsynonymous SNV 1 62 1 11 1 1  71 5
synonymous SNV   1  1    1    1  6
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chrX:43652774p.F274L4
chrX:43698147p.L278L1
chrX:43626760p.V82V1
chrX:43637955p.A506T1
chrX:43655067p.A72D1
chrX:43698178p.L493L1
chrX:43626797p.D471H1
chrX:43639593p.P266L1
chrX:43655117p.R67S1
chrX:43626865p.G455G1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MAOB in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MAOB

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ADCY5,CSF3R,DGKI,FGF4,GLI3,GSG1L,INPP5J,
ITPRIPL2,KIAA0040,KRT32,LCMT1,MAOB,MYO15A,NDP,
OR4C46,PCDH20,PCDHAC2,PDYN,PSG3,PSG8,TRPS1
ACOT13,AIG1,ATP6V1E1,BLCAP,TMEM230,GTF2E2,HABP4,
IAH1,INPP5K,ISCU,MAOB,MBD2,PLEKHA8P1,RBPMS,
SLC16A2,SLC29A1,SNAPIN,EMC3,TSPAN3,UBE2L3,VTI1B

ANTXR2,ARHGAP10,CCDC69,F5,FAM129A,FHL1,COLGALT2,
GNB5,ITGA7,KLK7,LYNX1,MAOB,MEIS2,OSR1,
PDLIM7,PHYHIP,PLXNB3,PTPRZ1,ROR1,TMOD1,WWTR1
ABCD1,CDR2L,CITED1,DEFB131,DFNA5,ESRRG,FTCD,
GRIA4,HOXC11,KIFC3,MAOB,MGC45800,PHYHIPL,PLA2G4C,
PMP22,SFRP5,SFXN3,SLC16A4,SUSD2,TIAM2,TMEM25
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MAOB
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P27338; -.
ChemistryChEMBL CHEMBL2095205; -.
ChemistryGuidetoPHARMACOLOGY 2490; -.
Organism-specific databasesPharmGKB PA237; -.
Organism-specific databasesCTD 4129; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00191monoamine oxidase Billicit; approvedPhentermine
DB00752monoamine oxidase BapprovedTranylcypromine
DB00780monoamine oxidase BapprovedPhenelzine
DB00909monoamine oxidase Bapproved; investigationalZonisamide
DB01037monoamine oxidase Bapproved; investigationalSelegiline
DB01247monoamine oxidase BapprovedIsocarboxazid
DB01367monoamine oxidase BapprovedRasagiline
DB01442monoamine oxidase Billicit; experimentalMMDA
DB01472monoamine oxidase Billicit; experimental4-Methoxyamphetamine
DB01577monoamine oxidase Billicit; approvedMethamphetamine
DB01626monoamine oxidase BapprovedPargyline
DB02095monoamine oxidase BexperimentalIsatin
DB02211monoamine oxidase BexperimentalN-Methyl-N-Propargyl-1(R)-Aminoindan
DB02509monoamine oxidase BexperimentalFarnesol
DB02643monoamine oxidase BexperimentalN-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
DB02939monoamine oxidase Bexperimental[(1e)-4-Phenylbut-1-Enyl]Benzene
DB03147monoamine oxidase BexperimentalFlavin-Adenine Dinucleotide
DB03894monoamine oxidase BexperimentalN-Propargyl-1(S)-Aminoindan
DB04147monoamine oxidase BexperimentalLauryl Dimethylamine-N-Oxide
DB04307monoamine oxidase Bexperimental5-Hydroxy-N-Propargyl-1(R)-Aminoindan
DB04677monoamine oxidase BexperimentalN-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE
DB04820monoamine oxidase BwithdrawnNialamide
DB04821monoamine oxidase BwithdrawnNomifensine
DB04832monoamine oxidase BwithdrawnZimelidine
DB07512monoamine oxidase Bexperimental7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
DB07513monoamine oxidase Bexperimental7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE
DB08082monoamine oxidase BexperimentalN-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
DB08176monoamine oxidase Bexperimental(1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE
DB08480monoamine oxidase Bexperimental4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
DB08516monoamine oxidase Bexperimental(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
DB00988monoamine oxidase BapprovedDopamine
DB00368monoamine oxidase BapprovedNorepinephrine
DB01394monoamine oxidase BapprovedColchicine
DB00864monoamine oxidase Bapproved; investigationalTacrolimus
DB00370monoamine oxidase BapprovedMirtazapine
DB00715monoamine oxidase Bapproved; investigationalParoxetine
DB00215monoamine oxidase BapprovedCitalopram
DB00734monoamine oxidase Bapproved; investigationalRisperidone


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Cross referenced IDs for MAOB
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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