Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for MAOB

Basic gene info.	Gene symbol	MAOB
	Gene name	monoamine oxidase B
	Synonyms	-
	Cytomap	UCSC genome browser: Xp11.23
	Genomic location	chrX :43625856-43741721
	Type of gene	protein-coding
	RefGenes	NM_000898.4,
	Ensembl id	ENSG00000069535
	Description	MAO, brainMAO, plateletMAO-Badrenalin oxidaseamine oxidase [flavin-containing] Bmonoamine oxidase type Btyramine oxidase
	Modification date	20141207
dbXrefs	MIM : 309860
	HGNC : HGNC
	Ensembl : ENSG00000069535
	HPRD : 02401
	Vega : OTTHUMG00000021388
Protein	UniProt: P27338 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MAOB
	BioGPS: 4129
	Gene Expression Atlas: ENSG00000069535
	The Human Protein Atlas: ENSG00000069535
Pathway	NCI Pathway Interaction Database: MAOB
	KEGG: MAOB
	REACTOME: MAOB
	ConsensusPathDB
	Pathway Commons: MAOB
Metabolism	MetaCyc: MAOB
	HUMANCyc: MAOB
Regulation	Ensembl's Regulation: ENSG00000069535
	miRBase: chrX :43,625,856-43,741,721
	TargetScan: NM_000898
	cisRED: ENSG00000069535
Context	iHOP: MAOB
	cancer metabolism search in PubMed: MAOB
	UCL Cancer Institute: MAOB
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for MAOB(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: MAOB
	Familial Cancer Database: MAOB

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM KEGG_ARGININE_AND_PROLINE_METABOLISM KEGG_HISTIDINE_METABOLISM KEGG_TYROSINE_METABOLISM KEGG_PHENYLALANINE_METABOLISM KEGG_TRYPTOPHAN_METABOLISM KEGG_DRUG_METABOLISM_CYTOCHROME_P450

Others
OMIM	309860; gene.
Orphanet
Disease	KEGG Disease: MAOB
	MedGen: MAOB (Human Medical Genetics with Condition)
	ClinVar: MAOB
Phenotype	MGI: MAOB (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: MAOB

Mutations for MAOB

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAOB related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

AW794716

AAAS

324

53701363

53701914

MAOB

316

496

43626252

43626432

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=35)	Stat. for Synonymous SNVs (# total SNVs=17)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr23:43652774-43652774	p.F274L	4
chr23:43652797-43652797	p.P266L	3
chr23:43639593-43639593	p.E359K	2
chr23:43662570-43662570	p.T121A	2
chr23:43662605-43662605	p.P109L	2
chr23:43656441-43656441	p.L183L	2
chr23:43655067-43655067	p.V229V	2
chr23:43637938-43637938	p.E376D	2
chr23:43652716-43652716	p.S293L	1
chr23:43662652-43662652	p.?	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		1		9	2		2		1	1		2		1			6	1		9
# mutation		1		7	2		2		1	1		2		1			8	1		11
nonsynonymous SNV		1		6	2		1		1	1		1		1			7	1		5
synonymous SNV				1			1					1					1			6

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chrX:43652774	p.F274L	4
chrX:43698147	p.L278L	1
chrX:43626760	p.V82V	1
chrX:43637955	p.A506T	1
chrX:43655067	p.A72D	1
chrX:43698178	p.L493L	1
chrX:43626797	p.D471H	1
chrX:43639593	p.P266L	1
chrX:43655117	p.R67S	1
chrX:43626865	p.G455G	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for MAOB in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MAOB

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ADCY5,CSF3R,DGKI,FGF4,GLI3,GSG1L,INPP5J, ITPRIPL2,KIAA0040,KRT32,LCMT1,MAOB,MYO15A,NDP, OR4C46,PCDH20,PCDHAC2,PDYN,PSG3,PSG8,TRPS1	ACOT13,AIG1,ATP6V1E1,BLCAP,TMEM230,GTF2E2,HABP4, IAH1,INPP5K,ISCU,MAOB,MBD2,PLEKHA8P1,RBPMS, SLC16A2,SLC29A1,SNAPIN,EMC3,TSPAN3,UBE2L3,VTI1B

ANTXR2,ARHGAP10,CCDC69,F5,FAM129A,FHL1,COLGALT2, GNB5,ITGA7,KLK7,LYNX1,MAOB,MEIS2,OSR1, PDLIM7,PHYHIP,PLXNB3,PTPRZ1,ROR1,TMOD1,WWTR1	ABCD1,CDR2L,CITED1,DEFB131,DFNA5,ESRRG,FTCD, GRIA4,HOXC11,KIFC3,MAOB,MGC45800,PHYHIPL,PLA2G4C, PMP22,SFRP5,SFXN3,SLC16A4,SUSD2,TIAM2,TMEM25

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MAOB

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Chemistry	BindingDB	P27338; -.
Chemistry	ChEMBL	CHEMBL2095205; -.
Chemistry	GuidetoPHARMACOLOGY	2490; -.
Organism-specific databases	PharmGKB	PA237; -.
Organism-specific databases	CTD	4129; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00191	monoamine oxidase B	illicit; approved	Phentermine
DB00752	monoamine oxidase B	approved	Tranylcypromine
DB00780	monoamine oxidase B	approved	Phenelzine
DB00909	monoamine oxidase B	approved; investigational	Zonisamide
DB01037	monoamine oxidase B	approved; investigational	Selegiline
DB01247	monoamine oxidase B	approved	Isocarboxazid
DB01367	monoamine oxidase B	approved	Rasagiline
DB01442	monoamine oxidase B	illicit; experimental	MMDA
DB01472	monoamine oxidase B	illicit; experimental	4-Methoxyamphetamine
DB01577	monoamine oxidase B	illicit; approved	Methamphetamine
DB01626	monoamine oxidase B	approved	Pargyline
DB02095	monoamine oxidase B	experimental	Isatin
DB02211	monoamine oxidase B	experimental	N-Methyl-N-Propargyl-1(R)-Aminoindan
DB02509	monoamine oxidase B	experimental	Farnesol
DB02643	monoamine oxidase B	experimental	N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
DB02939	monoamine oxidase B	experimental	[(1e)-4-Phenylbut-1-Enyl]Benzene
DB03147	monoamine oxidase B	experimental	Flavin-Adenine Dinucleotide
DB03894	monoamine oxidase B	experimental	N-Propargyl-1(S)-Aminoindan
DB04147	monoamine oxidase B	experimental	Lauryl Dimethylamine-N-Oxide
DB04307	monoamine oxidase B	experimental	5-Hydroxy-N-Propargyl-1(R)-Aminoindan
DB04677	monoamine oxidase B	experimental	N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE
DB04820	monoamine oxidase B	withdrawn	Nialamide
DB04821	monoamine oxidase B	withdrawn	Nomifensine
DB04832	monoamine oxidase B	withdrawn	Zimelidine
DB07512	monoamine oxidase B	experimental	7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
DB07513	monoamine oxidase B	experimental	7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE
DB08082	monoamine oxidase B	experimental	N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
DB08176	monoamine oxidase B	experimental	(1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE
DB08480	monoamine oxidase B	experimental	4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
DB08516	monoamine oxidase B	experimental	(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
DB00988	monoamine oxidase B	approved	Dopamine
DB00368	monoamine oxidase B	approved	Norepinephrine
DB01394	monoamine oxidase B	approved	Colchicine
DB00864	monoamine oxidase B	approved; investigational	Tacrolimus
DB00370	monoamine oxidase B	approved	Mirtazapine
DB00715	monoamine oxidase B	approved; investigational	Paroxetine
DB00215	monoamine oxidase B	approved	Citalopram
DB00734	monoamine oxidase B	approved; investigational	Risperidone

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Cross referenced IDs for MAOB

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information