Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for NME4

Basic gene info.	Gene symbol	NME4
	Gene name	NME/NM23 nucleoside diphosphate kinase 4
	Synonyms	NDPK-D\|NM23H4\|nm23-H4
	Cytomap	UCSC genome browser: 16p13.3
	Genomic location	chr16 :447191-450754
	Type of gene	protein-coding
	RefGenes	NM_001286433.1, NM_001286435.1,NM_001286436.1,NM_001286438.1,NM_001286439.1, NM_001286440.1,NM_005009.2,
	Ensembl id	ENSG00000103202
	Description	NDKNDP kinase DNDP kinase, mitochondrialNDPKDnon-metastatic cells 4, protein expressed innucleoside diphosphate kinase Dnucleoside diphosphate kinase, mitochondrial
	Modification date	20141207
dbXrefs	MIM : 601818
	HGNC : HGNC
	Ensembl : ENSG00000103202
	HPRD : 03489
	Vega : OTTHUMG00000047995
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_NME4
	BioGPS: 4833
	Gene Expression Atlas: ENSG00000103202
	The Human Protein Atlas: ENSG00000103202
Pathway	NCI Pathway Interaction Database: NME4
	KEGG: NME4
	REACTOME: NME4
	ConsensusPathDB
	Pathway Commons: NME4
Metabolism	MetaCyc: NME4
	HUMANCyc: NME4
Regulation	Ensembl's Regulation: ENSG00000103202
	miRBase: chr16 :447,191-450,754
	TargetScan: NM_001286433
	cisRED: ENSG00000103202
Context	iHOP: NME4
	cancer metabolism search in PubMed: NME4
	UCL Cancer Institute: NME4
Assigned class in ccmGDB	C

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Phenotypic Information for NME4(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: NME4
	Familial Cancer Database: NME4

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM REACTOME_METABOLISM_OF_NUCLEOTIDES

Others
OMIM
Orphanet
Disease	KEGG Disease: NME4
	MedGen: NME4 (Human Medical Genetics with Condition)
	ClinVar: NME4
Phenotype	MGI: NME4 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: NME4

Mutations for NME4

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NME4 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BQ305064	NME4	1	197	16	449730	450405	CALR	190	533	19	13050924	13051448
BF591148	NME4	11	431	16	450281	450758	NCL	425	576	2	232321395	232321782

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=5)	Stat. for Synonymous SNVs (# total SNVs=7)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr16:449659-449659	p.S120S	3
chr16:449049-449049	p.R51W	2
chr16:450309-450309	p.D177D	2
chr16:449124-449124	p.?	1
chr16:449378-449378	p.?	1
chr16:449673-449673	p.G125E	1
chr16:449726-449726	p.V143I	1
chr16:450231-450231	p.H151H	1
chr16:449051-449051	p.R51R	1
chr16:450233-450233	p.A152V	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample													1							2
# mutation													1							2
nonsynonymous SNV													1							1
synonymous SNV																				1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr16:449085	p.R63G,NME4	1
chr16:450284	p.S135I,NME4	1
chr16:450339	p.A153A,NME4	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for NME4 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for NME4

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ATP6V0C,C16orf13,ECI1,DECR2,FAM195A,FLYWCH2,ITFG3, JMJD8,MRPL28,MRPS34,NDUFB10,NME3,NME4,NMRAL1, NUBP2,RPUSD1,SERF2,SNRNP25,STUB1,TCEB2,PAM16	ANXA11,AP1M1,BCAP31,CARS,CCDC107,CD151,DOK1, GPX1,GPX4,IMPDH1,INF2,ITPK1,LGALS1,LZTR1, NME4,NUCB1,POLR2L,PRR5,RNPEPL1,TPD52L2,UROD

ATP5G2,BANF1,BCL11A,C16orf13,FAU,MPG,NAT14, NDUFB10,NME4,NUTF2,PACSIN3,PFDN2,PPP1R14B,PRR7, PTK7,RNPS1,RPL13,RPS2,TAF10,PAM16,TM7SF2	ANGPT1,FAM229B,DUSP22,EIF5A2,FAM195B,FEZ1,GNB4, GUCY1B3,HDGFRP3,KIAA0895,LOC399959,LOC644538,NME4,RAB23, IFT22,RHOQ,SMARCD3,SNCA,SPG20,TNFSF12,ZNF25

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for NME4

There's no related Drug.

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Cross referenced IDs for NME4

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information