Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for NPR1
Basic gene info.Gene symbolNPR1
Gene namenatriuretic peptide receptor 1
SynonymsANPRA|ANPa|GUC2A|GUCY2A|NPRA
CytomapUCSC genome browser: 1q21-q22
Genomic locationchr1 :153651163-153666468
Type of geneprotein-coding
RefGenesNM_000906.3,
Ensembl idENSG00000169418
DescriptionANP-AANPR-AGC-ANPR-Aatrial natriuretic peptide receptor 1atrial natriuretic peptide receptor type Aatrionatriuretic peptide receptor Aguanylate cyclase Anatriuretic peptide A type receptornatriuretic peptide receptor Anatriuretic peptide recepto
Modification date20141207
dbXrefs MIM : 108960
HGNC : HGNC
Ensembl : ENSG00000169418
HPRD : 00165
Vega : OTTHUMG00000037085
ProteinUniProt: P16066
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NPR1
BioGPS: 4881
Gene Expression Atlas: ENSG00000169418
The Human Protein Atlas: ENSG00000169418
PathwayNCI Pathway Interaction Database: NPR1
KEGG: NPR1
REACTOME: NPR1
ConsensusPathDB
Pathway Commons: NPR1
MetabolismMetaCyc: NPR1
HUMANCyc: NPR1
RegulationEnsembl's Regulation: ENSG00000169418
miRBase: chr1 :153,651,163-153,666,468
TargetScan: NM_000906
cisRED: ENSG00000169418
ContextiHOP: NPR1
cancer metabolism search in PubMed: NPR1
UCL Cancer Institute: NPR1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of NPR1 in cancer cell metabolism1. Cavalieri D, Dolara P, Mini E, Luceri C, Castagnini C, et al. (2007) Analysis of gene expression profiles reveals novel correlations with the clinical course of colorectal cancer. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 16: 535-548. go to article

Top
Phenotypic Information for NPR1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: NPR1
Familial Cancer Database: NPR1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM

check002.gifOthers
OMIM 108960; gene.
Orphanet
DiseaseKEGG Disease: NPR1
MedGen: NPR1 (Human Medical Genetics with Condition)
ClinVar: NPR1
PhenotypeMGI: NPR1 (International Mouse Phenotyping Consortium)
PhenomicDB: NPR1

Mutations for NPR1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NPR1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=93)
Stat. for Synonymous SNVs
(# total SNVs=24)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=1)

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr1:153665653-153665653p.R1035*5
chr1:153661483-153661483p.A824A3
chr1:153658636-153658636p.R573H3
chr1:153660672-153660672p.R798C3
chr1:153659714-153659714p.H658Q2
chr1:153658621-153658621p.R568P2
chr1:153661759-153661759p.A887V2
chr1:153661760-153661760p.A887A2
chr1:153655965-153655965p.N459N2
chr1:153659132-153659132p.V590G2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample 41182 3 4  11752 141018
# mutation 41173 3 4  12752 1911113
nonsynonymous SNV 3 133 1 3  1133  139111
synonymous SNV 114  2 1  1422 62 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr1:153660672p.R798C3
chr1:153661759p.A824A3
chr1:153661483p.A887V3
chr1:153658636p.E870K2
chr1:153661707p.R573H2
chr1:153659558p.N459N1
chr1:153661494p.T577K1
chr1:153655054p.R671R1
chr1:153659771p.Q781Q1
chr1:153662393p.A887A1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for NPR1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for NPR1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AOC3,AQP7,ARHGEF15,CD300LG,CD34,CDH5,CXorf36,
GPIHBP1,GPR146,ITIH5,KCNIP2,MMRN2,NPR1,PDE2A,
PLIN1,ROBO4,S1PR1,SDPR,TIE1,TMEM132C,VWF
ACO1,ALDH2,AOC3,BOK,CALB2,CAMK1,CEBPA,
CIDEC,EHD2,ESYT1,GPD1,HEPACAM,HEPN1,LIPE,
MCAM,MGLL,NAT8L,NPR1,PLIN1,TUSC5,TYRO3

ADAMTS1,ARHGEF15,CXorf36,ERG,FBLN5,FZD4,FAM110D,
IL1R1,LHFP,MAP1B,MMRN2,NPR1,PALMD,PECAM1,
S1PR1,SHE,SLIT3,SOX17,STARD8,SVEP1,TIE1
AEBP1,ARHGEF15,CADM3,CD248,CD34,CDH5,COL14A1,
EBF1,ELN,FAIM2,FAM43B,FBLN1,FBLN2,GPR133,
MMRN2,NPR1,PCDHGC3,SLIT3,STK32B,TIE1,WTIP
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for NPR1


There's no related Drug.
Top
Cross referenced IDs for NPR1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas