Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for EDEM2

Basic gene info.	Gene symbol	EDEM2
	Gene name	ER degradation enhancer, mannosidase alpha-like 2
	Synonyms	C20orf31\|C20orf49\|bA4204.1
	Cytomap	UCSC genome browser: 20q11.22
	Genomic location	chr20 :33703159-33735161
	Type of gene	protein-coding
	RefGenes	NM_001145025.1, NM_018217.2,NR_026728.1,
	Ensembl id	ENSG00000088298
	Description	ER degradation-enhancing alpha-mannosidase-like 2ER degradation-enhancing alpha-mannosidase-like protein 2ER degradation-enhancing-mannosidase-like protein 2
	Modification date	20141207
dbXrefs	MIM : 610302
	HGNC : HGNC
	Ensembl : ENSG00000088298
	HPRD : 09841
	Vega : OTTHUMG00000032322
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_EDEM2
	BioGPS: 55741
	Gene Expression Atlas: ENSG00000088298
	The Human Protein Atlas: ENSG00000088298
Pathway	NCI Pathway Interaction Database: EDEM2
	KEGG: EDEM2
	REACTOME: EDEM2
	ConsensusPathDB
	Pathway Commons: EDEM2
Metabolism	MetaCyc: EDEM2
	HUMANCyc: EDEM2
Regulation	Ensembl's Regulation: ENSG00000088298
	miRBase: chr20 :33,703,159-33,735,161
	TargetScan: NM_001145025
	cisRED: ENSG00000088298
Context	iHOP: EDEM2
	cancer metabolism search in PubMed: EDEM2
	UCL Cancer Institute: EDEM2
Assigned class in ccmGDB	C

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Phenotypic Information for EDEM2(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: EDEM2
	Familial Cancer Database: EDEM2

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

Others
OMIM
Orphanet
Disease	KEGG Disease: EDEM2
	MedGen: EDEM2 (Human Medical Genetics with Condition)
	ClinVar: EDEM2
Phenotype	MGI: EDEM2 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: EDEM2

Mutations for EDEM2

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.

- For Intra-chromosomal Variations

There's no intra-chromosomal structural variation.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
pancreas	EDEM2	chr20	33706811	33706831		chr17	62380871	62380891
pancreas	EDEM2	chr20	33721436	33721456	PRKCA	chr17	64333251	64333271

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows EDEM2 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
AK128432	BIRC6	1	2896	2	32720913	32723809	EDEM2	2893	3032	20	33865130	33865269
BQ015907	EDEM2	18	195	20	33856389	33856566	CTSS	192	679	1	150705384	150722629
BE938093	NAPB	12	316	20	23355439	23356179	EDEM2	311	415	20	33703350	33703454

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=35)	Stat. for Synonymous SNVs (# total SNVs=8)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr20:33703611-33703611	p.F454F	2
chr20:33711741-33711741	p.P356S	2
chr20:33703408-33703408	p.S522L	2
chr20:33725697-33725697	p.R159Q	2
chr20:33722565-33722565	p.W226C	2
chr20:33703523-33703523	p.A484T	1
chr20:33722577-33722577	p.L222F	1
chr20:33703702-33703702	p.R424H	1
chr20:33730281-33730281	p.I87L	1
chr20:33714096-33714096	p.M309I	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	3	2		6					1			6	2				7	3		4
# mutation	3	2		6					1			8	2				7	3		4
nonsynonymous SNV	1	2		5								6	1				5	1		4
synonymous SNV	2			1					1			2	1				2	2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr20:33703611	p.F417F,EDEM2	2
chr20:33703557	p.F392F,EDEM2	1
chr20:33711741	p.T153T,EDEM2	1
chr20:33722705	p.G372R,EDEM2	1
chr20:33703597	p.H143Y,EDEM2	1
chr20:33711807	p.A346V,EDEM2	1
chr20:33722742	p.T130T,EDEM2	1
chr20:33714096	p.A531S,EDEM2	1
chr20:33703271	p.M341V,EDEM2	1
chr20:33722746	p.Q129L,EDEM2	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for EDEM2 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for EDEM2

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACSS2,C20orf24,AAR2,CEP250,CPNE1,DLGAP4,DSN1, DYNLRB1,EDEM2,EIF2S2,EIF6,ERGIC3,GSS,MAP1LC3A, MMP24,NFS1,PIGU,RALY,ROMO1,TRPC4AP,UQCC1	ARHGDIA,ARPC4,C17orf62,C19orf10,CALR,CLIC1,CNPY3, CRELD2,DBNL,DNASE2,EDEM2,GNPTG,HM13,NECAP2, NUDT18,OS9,PPIB,SHISA5,SNX17,TMSB10,TRADD

ACOT8,AHCY,C20orf24,AAR2,COMMD7,CTNNBL1,DYNLRB1, EDEM2,EIF6,ERGIC3,NFS1,PDRG1,PIGU,PSMA7, RALY,ROMO1,SYS1,TP53RK,TPD52L2,TRPC4AP,UQCC1	APH1A,ATPIF1,PTRHD1,CCDC71,EDEM2,ERGIC3,IMP3, ISCA2,JTB,KRTCAP3,MAPKAPK3,NUDT16L1,RAB25,RPS29, STAMBP,STK16,TMEM179B,TXN2,UBAC2,UXT,YDJC

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for EDEM2

There's no related Drug.

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Cross referenced IDs for EDEM2

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information