Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for UGGT1
Basic gene info.Gene symbolUGGT1
Gene nameUDP-glucose glycoprotein glucosyltransferase 1
SynonymsHUGT1|UGCGL1|UGT1
CytomapUCSC genome browser: 2q14.3
Genomic locationchr2 :128848753-128953249
Type of geneprotein-coding
RefGenesNM_001025777.1,
NM_020120.3,NR_027671.2,
Ensembl idENSG00000136731
DescriptionUDP--Glc:glycoprotein glucosyltransferaseUDP-glucose ceramide glucosyltransferase-like 1UDP-glucose:glycoprotein glucosyltransferase 1
Modification date20141207
dbXrefs MIM : 605897
HGNC : HGNC
Ensembl : ENSG00000136731
HPRD : 12064
Vega : OTTHUMG00000131570
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UGGT1
BioGPS: 56886
Gene Expression Atlas: ENSG00000136731
The Human Protein Atlas: ENSG00000136731
PathwayNCI Pathway Interaction Database: UGGT1
KEGG: UGGT1
REACTOME: UGGT1
ConsensusPathDB
Pathway Commons: UGGT1
MetabolismMetaCyc: UGGT1
HUMANCyc: UGGT1
RegulationEnsembl's Regulation: ENSG00000136731
miRBase: chr2 :128,848,753-128,953,249
TargetScan: NM_001025777
cisRED: ENSG00000136731
ContextiHOP: UGGT1
cancer metabolism search in PubMed: UGGT1
UCL Cancer Institute: UGGT1
Assigned class in ccmGDBC

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Phenotypic Information for UGGT1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: UGGT1
Familial Cancer Database: UGGT1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: UGGT1
MedGen: UGGT1 (Human Medical Genetics with Condition)
ClinVar: UGGT1
PhenotypeMGI: UGGT1 (International Mouse Phenotyping Consortium)
PhenomicDB: UGGT1

Mutations for UGGT1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGGT1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BE930748ISM1169201327583213275932UGGT1663052128939832128944349
BI041241VASH11145147724919477249339UGGT11312072128950162128950238
BE881501UGGT114492128947371128947822RPL364424851956916355691678
BM463172UGGT181932128951479128951664UGGT11898722128949366128950040
AI148255SLC30A6730323244651232446808UGGT13023952128948993128949086
AK025416C10orf991575108593349485944737UGGT157120422128951780128953251

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=114)
Stat. for Synonymous SNVs
(# total SNVs=26)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr2:128945049-128945049p.P1501P3
chr2:128936143-128936143p.R1272H3
chr2:128886622-128886622p.N416D3
chr2:128867254-128867254p.S152L2
chr2:128867271-128867271p.T158A2
chr2:128886666-128886666p.E430E2
chr2:128944281-128944281p.Q1462*2
chr2:128927915-128927915p.V992G2
chr2:128913089-128913089p.R722G2
chr2:128886624-128886624p.N416N2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample621253 3 71 1162  128 17
# mutation621263 3 81 1162  139 24
nonsynonymous SNV521213 1 4  842  98 18
synonymous SNV1  5  2 41 32   41 6
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr2:128886622p.N416D4
chr2:128867254p.N416N2
chr2:128886624p.S152L2
chr2:128928849p.I921L1
chr2:128944345p.K1060N1
chr2:128867290p.L62V1
chr2:128903499p.T1298T1
chr2:128935411p.I202F1
chr2:128877960p.P1549L1
chr2:128917198p.F715F1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for UGGT1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for UGGT1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AMMECR1L,ANAPC1,ASXL2,BIRC6,DDX18,IWS1,LOC284441,
MAP3K2,MFSD9,NBEAL1,PTPN4,RANBP2,RIF1,SAP130,
SLC30A6,STRN,TOR1AIP2,TRIP12,UGGT1,USP34,ZDHHC20
ANKFY1,CLOCK,DNAJC10,DPY19L3,ENTPD4,OTULIN,GNL3L,
INTS2,MOB1A,NEK6,NIN,PAFAH1B2,PLEKHA8,PRKDC,
SCYL2,SEC23IP,SLFN12,UGGT1,VPS8,ZDHHC20,ZNF81

ANAPC1,ARID1A,ASXL2,PRRC2C,CLASP1,DNAJC10,FAM168B,
GIGYF2,NSD1,POLR1A,RIF1,SAP130,SNRNP200,TAOK1,
TET3,TGFBRAP1,TRIP12,TTLL4,UBR3,UGGT1,USP34
AQR,ASCC3,ATR,PRRC2C,CDK12,DHX9,EIF4G1,
EPRS,GANAB,HNRNPU,LARP1,LMNB2,MKI67,PRKDC,
RFWD3,SBNO1,TAF15,TRIP11,UGGT1,VPRBP,XPO5
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for UGGT1


There's no related Drug.
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Cross referenced IDs for UGGT1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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