Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for UGT2B7
Basic gene info.Gene symbolUGT2B7
Gene nameUDP glucuronosyltransferase 2 family, polypeptide B7
SynonymsUDPGT 2B9|UDPGT2B7|UDPGTH2|UGT2B9
CytomapUCSC genome browser: 4q13
Genomic locationchr4 :69962192-69978705
Type of geneprotein-coding
RefGenesNM_001074.2,
Ensembl idENSG00000171234
Description3,4-catechol estrogen specific3,4-catechol estrogen-specific UDPGTUDP glucuronosyltransferase 2B7UDP-glucuronosyltransferase 2B7UDP-glucuronosyltransferase 2B9UDP-glucuronyltransferase, family 2, beta-7UDPGT 2B7UDPGTh-2
Modification date20141207
dbXrefs MIM : 600068
HGNC : HGNC
Ensembl : ENSG00000171234
HPRD : 02508
Vega : OTTHUMG00000129404
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UGT2B7
BioGPS: 7364
Gene Expression Atlas: ENSG00000171234
The Human Protein Atlas: ENSG00000171234
PathwayNCI Pathway Interaction Database: UGT2B7
KEGG: UGT2B7
REACTOME: UGT2B7
ConsensusPathDB
Pathway Commons: UGT2B7
MetabolismMetaCyc: UGT2B7
HUMANCyc: UGT2B7
RegulationEnsembl's Regulation: ENSG00000171234
miRBase: chr4 :69,962,192-69,978,705
TargetScan: NM_001074
cisRED: ENSG00000171234
ContextiHOP: UGT2B7
cancer metabolism search in PubMed: UGT2B7
UCL Cancer Institute: UGT2B7
Assigned class in ccmGDBC

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Phenotypic Information for UGT2B7(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: UGT2B7
Familial Cancer Database: UGT2B7
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_ASCORBATE_AND_ALDARATE_METABOLISM
KEGG_STARCH_AND_SUCROSE_METABOLISM
KEGG_RETINOL_METABOLISM
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_CYTOCHROME_P450
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: UGT2B7
MedGen: UGT2B7 (Human Medical Genetics with Condition)
ClinVar: UGT2B7
PhenotypeMGI: UGT2B7 (International Mouse Phenotyping Consortium)
PhenomicDB: UGT2B7

Mutations for UGT2B7
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT2B7 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
T05729UGT2B7110046996900869969107FTO100353165414678254147030

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=6

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=57)
Stat. for Synonymous SNVs
(# total SNVs=25)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=2)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:69962701-69962701p.P155S5
chr4:69962911-69962911p.E225K4
chr4:69962460-69962460p.I74M3
chr4:69973826-69973826p.P366T3
chr4:69962910-69962910p.F224F3
chr4:69974041-69974041p.?2
chr4:69962448-69962448p.S70S2
chr4:69962721-69962721p.A161A2
chr4:69964299-69964299p.V255I2
chr4:69973827-69973827p.P366L2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample22 94 6 32 132  221319
# mutation22 94 6 32 132  224419
nonsynonymous SNV11 92 3 21 92  120315
synonymous SNV11  2 3 11 4   141 4
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:69973826p.P366T3
chr4:69962448p.D482N2
chr4:69978308p.S70S2
chr4:69962880p.P284L2
chr4:69964387p.A523G2
chr4:69962911p.M214I2
chr4:69978432p.E225K2
chr4:69962806p.A480A1
chr4:69973959p.L46R1
chr4:69962362p.L172L1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for UGT2B7 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for UGT2B7

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ALDH18A1,ALPP,ALPPL2,B3GNT3,B3GNT7,CLDN2,COX18,
GRSF1,GZF1,LOC84931,MALL,NKX6-2,NXT1,PRR18,
SAT1,SLC5A11,TAAR6,UGT2B10,UGT2B11,UGT2B7,VSTM2L
ACSL3,ADAM2,AFMID,ALOX15B,B3GAT1,C15orf43,DHRS2,
EPS8L3,GGT1,HPGD,IDI1,IYD,KYNU,NSUN2,
PNLIPRP3,SERHL2,SERHL,SLC15A1,TARP,TMPRSS11F,UGT2B7

C1orf105,CHRNA2,DLX6AS,GPR83,GPR98,KCTD16,KRT36,
KRT37,KRT38,LCN10,MYL3,NAV2,RPS6KC1,SULT1C4,
TGM5,TMPRSS6,UGT2A3,UGT2B10,UGT2B7,UNC13C,USH1G
AKR1C4,ALDOC,SLC25A47,C9orf24,CCDC108,CRIP1,CYP2J2,
DNASE1,F11,KCNH6,MLXIPL,NR0B2,PDZK1,PFKFB4,
PIK3C2G,PLB1,PRODH,SI,TM4SF5,UGT2B7,VNN1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for UGT2B7
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00675UDP glucuronosyltransferase 2 family, polypeptide B7approvedTamoxifen
DB01544UDP glucuronosyltransferase 2 family, polypeptide B7illicit; approvedFlunitrazepam
DB00317UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalGefitinib
DB00184UDP glucuronosyltransferase 2 family, polypeptide B7approvedNicotine
DB00318UDP glucuronosyltransferase 2 family, polypeptide B7illicit; approvedCodeine
DB00495UDP glucuronosyltransferase 2 family, polypeptide B7approvedZidovudine
DB00678UDP glucuronosyltransferase 2 family, polypeptide B7approvedLosartan
DB00564UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalCarbamazepine
DB00445UDP glucuronosyltransferase 2 family, polypeptide B7approvedEpirubicin
DB00333UDP glucuronosyltransferase 2 family, polypeptide B7approvedMethadone
DB00683UDP glucuronosyltransferase 2 family, polypeptide B7illicit; approvedMidazolam
DB00186UDP glucuronosyltransferase 2 family, polypeptide B7approvedLorazepam
DB00313UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalValproic Acid
DB00295UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalMorphine
DB00586UDP glucuronosyltransferase 2 family, polypeptide B7approvedDiclofenac
DB00688UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalMycophenolate mofetil
DB00921UDP glucuronosyltransferase 2 family, polypeptide B7illicit; approved; investigationalBuprenorphine
DB00446UDP glucuronosyltransferase 2 family, polypeptide B7approvedChloramphenicol
DB00842UDP glucuronosyltransferase 2 family, polypeptide B7approvedOxazepam
DB00497UDP glucuronosyltransferase 2 family, polypeptide B7illicit; approved; investigationalOxycodone
DB00231UDP glucuronosyltransferase 2 family, polypeptide B7approvedTemazepam
DB01273UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalVarenicline
DB01024UDP glucuronosyltransferase 2 family, polypeptide B7approvedMycophenolic acid
DB06697UDP glucuronosyltransferase 2 family, polypeptide B7approvedArtemether
DB00625UDP glucuronosyltransferase 2 family, polypeptide B7approved; investigationalEfavirenz
DB00712UDP glucuronosyltransferase 2 family, polypeptide B7approvedFlurbiprofen
DB01050UDP glucuronosyltransferase 2 family, polypeptide B7approvedIbuprofen
DB01009UDP glucuronosyltransferase 2 family, polypeptide B7approvedKetoprofen


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Cross referenced IDs for UGT2B7
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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