Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CES2
Basic gene info.Gene symbolCES2
Gene namecarboxylesterase 2
SynonymsCE-2|CES2A1|PCE-2|iCE
CytomapUCSC genome browser: 16q22.1
Genomic locationchr16 :66968346-66978994
Type of geneprotein-coding
RefGenesNM_003869.5,
NM_198061.2,NR_036684.1,
Ensembl idENSG00000172831
Descriptioncarboxylesterase 2 (intestine, liver)cocaine esterasehCE-2intestinal carboxylesterase; liver carboxylesterase-2methylumbelliferyl-acetate deacetylase 2
Modification date20141207
dbXrefs MIM : 605278
HGNC : HGNC
Ensembl : ENSG00000172831
HPRD : 07062
Vega : OTTHUMG00000137517
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CES2
BioGPS: 8824
Gene Expression Atlas: ENSG00000172831
The Human Protein Atlas: ENSG00000172831
PathwayNCI Pathway Interaction Database: CES2
KEGG: CES2
REACTOME: CES2
ConsensusPathDB
Pathway Commons: CES2
MetabolismMetaCyc: CES2
HUMANCyc: CES2
RegulationEnsembl's Regulation: ENSG00000172831
miRBase: chr16 :66,968,346-66,978,994
TargetScan: NM_003869
cisRED: ENSG00000172831
ContextiHOP: CES2
cancer metabolism search in PubMed: CES2
UCL Cancer Institute: CES2
Assigned class in ccmGDBC

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Phenotypic Information for CES2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CES2
Familial Cancer Database: CES2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_DRUG_METABOLISM_OTHER_ENZYMES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: CES2
MedGen: CES2 (Human Medical Genetics with Condition)
ClinVar: CES2
PhenotypeMGI: CES2 (International Mouse Phenotyping Consortium)
PhenomicDB: CES2

Mutations for CES2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CES2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
CA427622CES223324166697823966978540CES2323671166697661566977943
BG036772CES26151166696835266968497CCDC9214953812124427894124457214
AA368402PTTG1IP196214627016446270259CES293183166696873766968827
AW955878PTTG1IP196214627016446270259CES293617166696873766969262
CN478636CES212154166697885766978999CES2146450166697790566978209
AW882114ECE11518912154484921545023CES2187330166697859866978741

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=25)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr16:66974489-66974489p.S300L3
chr16:66975531-66975531p.F410F3
chr16:66974389-66974389p.A267T3
chr16:66975424-66975424p.P375S2
chr16:66972053-66972053p.A128T2
chr16:66976111-66976111p.S478F2
chr16:66974142-66974142p.H211H2
chr16:66974153-66974153p.L215H2
chr16:66975693-66975693p.Q424R2
chr16:66974180-66974180p.D224G2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample21 4  9 3  21   88 4
# mutation21 4  9 3  21   88 4
nonsynonymous SNV21 2  7 2  1    46 1
synonymous SNV   2  2 1  11   42 3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:66974398p.F410F,CES22
chr16:66975531p.R270C,CES22
chr16:66975441p.L160P,CES21
chr16:66972074p.P370L,CES21
chr16:66977822p.E200Q,CES21
chr16:66975486p.P375S,CES21
chr16:66972087p.P205P,CES21
chr16:66977823p.G380G,CES21
chr16:66974469p.H211H,CES21
chr16:66972139p.D395E,CES21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CES2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for CES2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ATP6V0D1,BBS2,C16orf70,CES2,COG8,EDC4,ELMO3,
FAM65A,FBXO31,FUK,GAS8,GFOD2,KATNB1,IST1,
MLYCD,PRMT7,PSKH1,RANBP10,TK2,TANGO6,VPS4A
ACTR1B,BAP1,BAG6,C3orf18,CAMTA2,CES2,COG4,
DNAJC11,EVI5L,EXOC3,NLRX1,NOL3,NUDCD3,PRDX2,
RMND5B,RPTOR,TBC1D17,VPS4A,WBSCR16,ZER1,ZFAND3

ASTE1,TMEM253,CALCB,CES2,CHP2,CLDN15,CLDN22,
CYP7A1,DHRS11,HNF4A,INSC,OSTalpha,PRSS8,RAB22A,
SERPINE3,SLC7A9,SULT1A2,TM6SF2,TMEM150B,TMEM229A,TMEM82
SOWAHA,CDHR5,CES2,DHRS11,GDPD2,HNF1A,INPP5J,
IYD,KIAA2013,MEP1A,MOGAT2,MYO1A,NGEF,PIGS,
POR,RAB17,SLC22A4,SLC39A5,SLC3A1,USH1C,VIL1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for CES2
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00951carboxylesterase 2approvedIsoniazid
DB06209carboxylesterase 2approved; investigationalPrasugrel
DB01101carboxylesterase 2approved; investigationalCapecitabine
DB00544carboxylesterase 2approvedFluorouracil
DB00762carboxylesterase 2approved; investigationalIrinotecan


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Cross referenced IDs for CES2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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