Cancer Cell Metabolism Gene Database

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MUC16
Basic gene info.Gene symbolMUC16
Gene namemucin 16, cell surface associated
SynonymsCA125
CytomapUCSC genome browser: 19p13.2
Genomic locationchr19 :8959519-9092018
Type of geneprotein-coding
RefGenesNM_024690.2,
Ensembl idENSG00000181143
DescriptionCA-125CA125 ovarian cancer antigenMUC-16mucin-16ovarian cancer-related tumor marker CA125ovarian carcinoma antigen CA125
Modification date20141222
dbXrefs MIM : 606154
HGNC : HGNC
Ensembl : ENSG00000181143
Vega : OTTHUMG00000169191
ProteinUniProt: Q8WXI7
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MUC16
BioGPS: 94025
Gene Expression Atlas: ENSG00000181143
The Human Protein Atlas: ENSG00000181143
PathwayNCI Pathway Interaction Database: MUC16
KEGG: MUC16
REACTOME: MUC16
ConsensusPathDB
Pathway Commons: MUC16
MetabolismMetaCyc: MUC16
HUMANCyc: MUC16
RegulationEnsembl's Regulation: ENSG00000181143
miRBase: chr19 :8,959,519-9,092,018
TargetScan: NM_024690
cisRED: ENSG00000181143
ContextiHOP: MUC16
cancer metabolism search in PubMed: MUC16
UCL Cancer Institute: MUC16
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of MUC16 in cancer cell metabolism1. Haridas D, Ponnusamy MP, Chugh S, Lakshmanan I, Seshacharyulu P, et al. (2014) MUC16: molecular analysis and its functional implications in benign and malignant conditions. The FASEB Journal 28: 4183-4199. go to article
2. Shukla SK, Gunda V, Abrego J, Haridas D, Mishra A, et al. (2015) MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism. Oncotarget. go to article

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Phenotypic Information for MUC16(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MUC16
Familial Cancer Database: MUC16
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM 606154; gene.
Orphanet
DiseaseKEGG Disease: MUC16
MedGen: MUC16 (Human Medical Genetics with Condition)
ClinVar: MUC16
PhenotypeMGI: MUC16 (International Mouse Phenotyping Consortium)
PhenomicDB: MUC16

Mutations for MUC16
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryMUC16chr1989716228971642MUC16chr1989783868978406
ovaryMUC16chr1989772198977239FLJ30838chr25894772758947747
ovaryMUC16chr1990351459035165MUC16chr1990355749035594
ovaryMUC16chr1990505639050583chr1992920489292068
ovaryMUC16chr1990558719055891ZNF317chr1992684209268440
ovaryMUC16chr1990808989080918chr1990937269093746
ovaryMUC16chr1990845509084570chr1991017659101785
ovaryMUC16chr1990889839089003chr1992336869233706
pancreasMUC16chr1990279829028002ARHGAP35chr194744102147441041
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC16 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AK023298MUC1614331990499949056241DNAJC224281559124974276649745683
AU133673MUC1614341990499949056241DNAJC22429680124974276649743198
AA640762MUC1641371990004829001879MUC161313551989994569000489
BI013178MUC1682341989666868969304SCUBE321851963519738035197681

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample2314213 5 8 62115
GAIN (# sample)2214  2 3 6 6 1 3
LOSS (# sample) 1  211 2 2  2 12
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=8

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=1125)
Stat. for Synonymous SNVs
(# total SNVs=357)
Stat. for Deletions
(# total SNVs=17)
Stat. for Insertions
(# total SNVs=6)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:9090831-9090831p.P328P8
chr19:9072091-9072091p.P5119S6
chr19:9080501-9080501p.G3177E6
chr19:9067623-9067623p.S6608*5
chr19:9063678-9063678p.D7923A4
chr19:9072086-9072086p.S5120S4
chr19:9068980-9068980p.A6156T4
chr19:9060904-9060904p.E8848K4
chr19:9085145-9085145p.A2224T4
chr19:9061629-9061629p.R8606H4

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=9

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample53761014462 7525911518097262151941022073
# mutation74871730065 1132661153551952731797620318210
nonsynonymous SNV56591321846 81151932651341721168914211153
synonymous SNV182848319 32115229061101628761757
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:9072091p.P5119S9
chr19:9090831p.P328P8
chr19:9048764p.L10956P8
chr19:9048771p.F10954L5
chr19:9014654p.G3177E4
chr19:9089508p.V769V4
chr19:9080501p.R12774H4
chr19:9085170p.S8282F3
chr19:9075414p.R8606H3
chr19:9068973p.S7000P3

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MUC16 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MUC16

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACSL6,APOBEC3B,ARHGEF9,CAPN14,CDC42EP1,CTSV,CXCL16,
KCNG1,KRT9,MFGE8,MUC16,PADI2,PGBD5,PLEKHG1,
PRKX,RAET1L,RASGEF1C,ROPN1,SLC15A1,TP53BP2,VGLL1
C12orf77,CD3G,COL22A1,CTLA4,DAPP1,GPR114,GRIN2A,
HLA-DOB,HORMAD1,ICOS,IKZF3,MIR155HG,MUC16,NLRC3,
OR7G1,P2RY10,RASSF5,TEX11,TLR10,TOX,ZNF80

ACTBL2,ANXA8,ANXA8L1,BPI,C8orf86,CGB1,CPA4,
CST6,FAM3C,IL20RB,KRT7,LIPK,LRAT,MUC16,
MYH16,PEX5L,PSG6,PSG9,SIGLEC15,THEG,WNT7A
C20orf141,NCOR1P1,CCDC129,CHAT,GNG13,GPX5,KLK13,
KPRP,LCE2C,LPA,MEPE,MUC16,CHODL-AS1,OR2D2,
PGLYRP3,SEBOX,SNORA79,TAS1R3,TRPM5,VTCN1,ZSWIM2
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MUC16


There's no related Drug.
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Cross referenced IDs for MUC16
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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