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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for TECR |
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Phenotypic Information for TECR(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: TECR |
Familial Cancer Database: TECR |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: TECR |
MedGen: TECR (Human Medical Genetics with Condition) | |
ClinVar: TECR | |
Phenotype | MGI: TECR (International Mouse Phenotyping Consortium) |
PhenomicDB: TECR |
Mutations for TECR |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | TECR | chr19 | 14653542 | 14653562 | TECR | chr19 | 14651490 | 14651510 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows TECR related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AA329184 | OSBPL5 | 1 | 164 | 11 | 3151627 | 3151790 | TECR | 162 | 296 | 19 | 14676568 | 14676895 | |
FJ423752 | STRN4 | 1 | 56 | 19 | 47230707 | 47230762 | TECR | 55 | 101 | 19 | 14673337 | 14673383 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   | 1 |   |   |   |   |   |   |   | 2 |   |   | 1 |   |   |   | |||
GAIN (# sample) | 1 |   | 1 |   |   |   |   |   |   |   | 2 |   |   | 1 |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=22) | (# total SNVs=1) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr19:14674030-14674030 | p.A27T | 2 |
chr19:14674503-14674503 | p.R51H | 2 |
chr19:14674812-14674812 | p.A96T | 2 |
chr19:14675793-14675793 | p.A199T | 2 |
chr19:14674878-14674878 | p.D118Y | 1 |
chr19:14676578-14676578 | p.G274G | 1 |
chr19:14674070-14674070 | p.? | 1 |
chr19:14674998-14674998 | p.A130T | 1 |
chr19:14676599-14676599 | p.W281* | 1 |
chr19:14674472-14674472 | p.P41S | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 2 |   |   | 3 |   |   |   |   |   |   | 2 | 1 |   | 2 | 1 |   | 1 |
# mutation | 2 | 1 |   | 2 |   |   | 3 |   |   |   |   |   |   | 2 | 1 |   | 2 | 1 |   | 1 |
nonsynonymous SNV | 1 | 1 |   | 2 |   |   | 3 |   |   |   |   |   |   | 2 | 1 |   | 2 | 1 |   | 1 |
synonymous SNV | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr19:14674714 | p.P98L | 1 |
chr19:14674819 | p.L99P | 1 |
chr19:14674822 | p.R150C | 1 |
chr19:14675058 | p.R159C | 1 |
chr19:14675085 | p.R159H | 1 |
chr19:14640523 | p.L183V | 1 |
chr19:14675086 | p.P187S | 1 |
chr19:14673357 | p.P231L | 1 |
chr19:14675655 | p.E5E | 1 |
chr19:14673380 | p.K12N | 1 |
Other DBs for Point Mutations |
Copy Number for TECR in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for TECR |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ABHD8,SMIM7,C19orf53,BABAM1,CC2D1A,DCAF15,DDA1, ELOF1,MVB12A,FKBP8,MPV17L2,MRPL34,NDUFA7,NDUFB7, PRDX2,PRKACA,RAB8A,RAD23A,TECR,USE1,WDR83 | CLPTM1,COX6A1,DCXR,DDT,DNAJC30,GRHPR,HINT2, HSD17B10,MRPL24,MRPL53,NDUFB8,NPRL3,NSDHL,PCBD1, PRDX2,PSMD8,SLC25A10,SLC2A4RG,TECR,TRAPPC2L,WBP2 |
TMEM258,C19orf43,KXD1,C19orf53,WDR83OS,COX6B1,DHPS, GADD45GIP1,LSM7,NDUFA13,NDUFA7,NDUFB4,NDUFB7,POLR2I, RAD23A,RFXANK,RNASEH2A,RPP21,TECR,TRAPPC5,UBA52 | ACSF3,EMC10,FAM213B,DNPH1,BLOC1S4,DDRGK1,ELMO3, FAM3A,IGSF8,ILVBL,PGAP2,PPP1R16A,SDF4,SLC35C2, TECR,TMEM125,TMEM52,TMUB1,UNC93B1,ZDHHC24,ZDHHC9 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for TECR |
There's no related Drug. |
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Cross referenced IDs for TECR |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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