Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ENTPD6
Basic gene info.Gene symbolENTPD6
Gene nameectonucleoside triphosphate diphosphohydrolase 6 (putative)
SynonymsCD39L2|IL-6SAG|IL6ST2|NTPDase-6|dJ738P15.3
CytomapUCSC genome browser: 20p11.21
Genomic locationchr20 :25176338-25207360
Type of geneprotein-coding
RefGenesNM_001114089.1,
NM_001247.2,
Ensembl idENSG00000197586
DescriptionCD39 antigen-like 2CD39-like 2HCV-E2 binding protein 1NTPDase 6ectonucleoside triphosphate diphosphohydrolase 6ectonucleoside triphosphate diphosphohydrolase 6 (putative function)interleukin 6 signal transducer-2
Modification date20141207
dbXrefs MIM : 603160
HGNC : HGNC
Ensembl : ENSG00000197586
HPRD : 16013
Vega : OTTHUMG00000032116
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ENTPD6
BioGPS: 955
Gene Expression Atlas: ENSG00000197586
The Human Protein Atlas: ENSG00000197586
PathwayNCI Pathway Interaction Database: ENTPD6
KEGG: ENTPD6
REACTOME: ENTPD6
ConsensusPathDB
Pathway Commons: ENTPD6
MetabolismMetaCyc: ENTPD6
HUMANCyc: ENTPD6
RegulationEnsembl's Regulation: ENSG00000197586
miRBase: chr20 :25,176,338-25,207,360
TargetScan: NM_001114089
cisRED: ENSG00000197586
ContextiHOP: ENTPD6
cancer metabolism search in PubMed: ENTPD6
UCL Cancer Institute: ENTPD6
Assigned class in ccmGDBC

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Phenotypic Information for ENTPD6(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ENTPD6
Familial Cancer Database: ENTPD6
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_PURINE_METABOLISM
KEGG_PYRIMIDINE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ENTPD6
MedGen: ENTPD6 (Human Medical Genetics with Condition)
ClinVar: ENTPD6
PhenotypeMGI: ENTPD6 (International Mouse Phenotyping Consortium)
PhenomicDB: ENTPD6

Mutations for ENTPD6
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENTPD6 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BE250167HEYL116614009182140091985ENTPD6163776202520643825207057
EL582886MPG117016135232135401ENTPD6166586202518727825187698
BE270227HEYL116414009182140091984ENTPD6161604202520643825206881
EL582887ENTPD631449202518728025187698MPG44561516135232135401
EL584050MPG117016135232135401ENTPD6166570202518729425187698
AA578001ENTPD6399202520720325207300ENTPD695332202520692925207166
EL583107MPG117016135232135401ENTPD6166576202518728825187698
EL584048MPG117016135232135401ENTPD6166583202518728025187698
DA046138ENTPD61322202519552325199246CGNL1311576155784112357841389
EL584399MPG117016135232135401ENTPD6166587202518727825187698
EL584406ENTPD631448202518728025187698MPG44457716135232135369
EL583106ENTPD631449202518728025187698MPG44561516135232135402
EL584404ENTPD631449202518728025187698MPG44561216135232135401
DB118034CAMTA1312333175384717538492ENTPD6326552202519553825198198

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=39)
Stat. for Synonymous SNVs
(# total SNVs=19)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr20:25193891-25193891p.?3
chr20:25187189-25187189p.R6H3
chr20:25203487-25203487p.H353H3
chr20:25198149-25198149p.Q270H2
chr20:25193949-25193949p.P168P2
chr20:25198181-25198181p.R281Q2
chr20:25201921-25201921p.E333K2
chr20:25187856-25187856p.A67T2
chr20:25196318-25196318p.S227L2
chr20:25187945-25187945p.D96D1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1316  4  1 76  274 12
# mutation1316  4  1 77  284 17
nonsynonymous SNV1214  1  1 54  242 10
synonymous SNV 1 2  3    23   42 7
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr20:25188018p.T104P,ENTPD63
chr20:25190505p.E316Q,ENTPD62
chr20:25198149p.Q253H,ENTPD62
chr20:25187856p.R264Q,ENTPD62
chr20:25198181p.E116K,ENTPD62
chr20:25201921p.A50T,ENTPD62
chr20:25203584p.A61A,ENTPD61
chr20:25201908p.S210L,ENTPD61
chr20:25190545p.G315V,ENTPD61
chr20:25204780p.K439N,ENTPD61

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ENTPD6 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ENTPD6

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ABHD12,CCDC22,CHMP4B,DDRGK1,ENTPD6,IDH3B,ITPA,
MAGIX,MRPL55,MRPS26,NDUFB11,NUDT14,OGFOD2,POLR2I,
PYGB,RFNG,SDHAF1,SNRPB,TIMM17B,UBOX5,WASH2P
ALKBH2,ASB6,SNHG20,C19orf48,CD82,DEAF1,ENTPD6,
GTF3C5,JMJD4,KCNN4,NAT9,PODXL2,PPFIA3,PRSS27,
PYGB,RPL3,SAMD10,SGSM3,TMCO4,TRMT1,ZMYND19

ABHD12,ACSS1,ACTR5,APMAP,AAR2,CHMP4B,CST3,
ENTPD6,GMEB2,GZF1,LPIN3,NANP,NAPB,NXT1,
PIGU,PPDPF,PYGB,RALY,SPATA2,TM9SF4,ZNF337
ADAP1,AP1M2,ARHGEF16,ARRDC1,KDF1,C6orf136,CBLC,
CDX1,CRB3,ENTPD6,GPR35,KLC4,PLEKHJ1,PRRG2,
PXMP2,SH2D3A,SIGIRR,SLC26A6,SLC35C2,SMPDL3B,TOR2A
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ENTPD6


There's no related Drug.
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Cross referenced IDs for ENTPD6
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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