Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for PRDX6

Basic gene info.	Gene symbol	PRDX6
	Gene name	peroxiredoxin 6
	Synonyms	1-Cys\|AOP2\|HEL-S-128m\|NSGPx\|PRX\|aiPLA2\|p29
	Cytomap	UCSC genome browser: 1q25.1
	Genomic location	chr1 :173446485-173457946
	Type of gene	protein-coding
	RefGenes	NM_004905.2,
	Ensembl id	ENSG00000117592
	Description	1-Cys PRX1-Cys peroxiredoxin24 kDa proteinacidic calcium-independent phospholipase A2antioxidant protein 2epididymis secretory sperm binding protein Li 128mliver 2D page spot 40non-selenium glutathione peroxidaseperoxiredoxin-6red blood cells pag
	Modification date	20141207
dbXrefs	MIM : 602316
	HGNC : HGNC
	Ensembl : ENSG00000117592
	HPRD : 03817
	Vega : OTTHUMG00000034804
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PRDX6
	BioGPS: 9588
	Gene Expression Atlas: ENSG00000117592
	The Human Protein Atlas: ENSG00000117592
Pathway	NCI Pathway Interaction Database: PRDX6
	KEGG: PRDX6
	REACTOME: PRDX6
	ConsensusPathDB
	Pathway Commons: PRDX6
Metabolism	MetaCyc: PRDX6
	HUMANCyc: PRDX6
Regulation	Ensembl's Regulation: ENSG00000117592
	miRBase: chr1 :173,446,485-173,457,946
	TargetScan: NM_004905
	cisRED: ENSG00000117592
Context	iHOP: PRDX6
	cancer metabolism search in PubMed: PRDX6
	UCL Cancer Institute: PRDX6
Assigned class in ccmGDB	C

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Phenotypic Information for PRDX6(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: PRDX6
	Familial Cancer Database: PRDX6

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_PHENYLALANINE_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: PRDX6
	MedGen: PRDX6 (Human Medical Genetics with Condition)
	ClinVar: PRDX6
Phenotype	MGI: PRDX6 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: PRDX6

Mutations for PRDX6

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PRDX6 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
CA439640	PRDX6	9	85	1	173457354	173457430	PRDX6	81	137	1	173457113	173457460
BG208010	MGST2	1	56	4	140661367	140661422	PRDX6	53	255	1	173450488	173454567
BM477858	PRDX6	1	490	1	173454581	173457150	PPP1R8	475	494	1	28167312	28167331
BF972933	GRID2	56	75	4	94123007	94123026	PRDX6	60	431	1	173455450	173457154

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=19)	Stat. for Synonymous SNVs (# total SNVs=3)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr1:173454533-173454533	p.E96*	3
chr1:173454569-173454569	p.R108W	2
chr1:173455466-173455466	p.D158N	1
chr1:173456935-173456935	p.P203L	1
chr1:173454563-173454563	p.R106G	1
chr1:173455471-173455471	p.E159D	1
chr1:173446537-173446537	p.M1V	1
chr1:173456983-173456983	p.R219H	1
chr1:173454564-173454564	p.R106M	1
chr1:173455474-173455474	p.I160M	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	2			4			1		1			3	3				4	1		3
# mutation	2			4			1		1			3	3				4	1		3
nonsynonymous SNV	2			3			1		1			3	2				4	1		3
synonymous SNV				1									1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr1:173456943	p.L143L	1
chr1:173454641	p.A151T	1
chr1:173456983	p.D158N	1
chr1:173446537	p.E159D	1
chr1:173455410	p.M1V	1
chr1:173446598	p.I160M	1
chr1:173455423	p.G21D	1
chr1:173450482	p.R162S	1
chr1:173455445	p.S38F	1
chr1:173450503	p.F202Y	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for PRDX6 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PRDX6

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACBD6,COA6,CACYBP,CCDC58,CCT3,GLRX2,HAX1, JTB,KRTCAP2,PFDN2,PIGC,PRDX6,PSMB4,PSMD4, RFWD2,SCNM1,SHFM1,SNRPC,SNRPE,THOC7,UCK2	ACAA2,BNIP3,FAM213A,PQLC2L,CIDEC,EIF4EBP2,FAM89A, FBXO27,GBE1,GHR,GNAI1,HADH,HRSP12,MAOA, MARC1,PLA2G16,PPARG,PPP1R1A,PRDX6,STBD1,EMC3

ALPI,C11orf86,LINC00520,C1orf94,CAPN11,CIDEC,CLCA4, CLDN23,CTSE,DHRS9,FAM25BP,GDPD2,GDPD3,GUCA2B, LOC646627,MYPN,PRDX6,TFF1,UGT1A4,UGT1A5,VSIG1	AMACR,CACFD1,CAPN2,CNNM4,FXYD3,KRTAP5-5,LIPH, LITAF,LOC646627,LSR,MARCH3,MMP24,MUC20,PEX26, PIGZ,PLCD3,PRDX6,RIMKLA,SERINC2,TMPRSS4,TSPAN7

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PRDX6

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB03661	peroxiredoxin 6	experimental	Cysteinesulfonic Acid

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Cross referenced IDs for PRDX6

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information