Accession	ELMIdentifier	Motif	FunctionalSiteName	Description	Regex
ELME000231	DEG_APCC_DBOX_1	APC D box	APCC-binding Destruction motifs	An RxxL-based motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner	.R..L..[LIVM].
ELME000232	DEG_APCC_KENBOX_2	APC KEN box	APCC-binding Destruction motifs	Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for  26S proteasome mediated degradation.	.KEN.
ELME000342	DEG_APCC_TPR_1	APC TPR motif	APCC_TPR-docking motifs	This short C-terminal motif is present in co-activators, the Doc1/APC10 subunit and some substrates of the APC/C and mediates direct binding to TPR-containing APC/C core subunits.	.[ILM]R$
ELME000426	DEG_COP1_1	COP1 motif	COP1 E3 ligase binding degron motif	A destruction motif interacts with the COP1 WD 40 domain for target ubiquitination and degradation.	[STDE]{1,3}.{0,2}[TSDE].{2,3}VP[STDE]G{0,1}[FLIMVYPA]
ELME000323	DEG_CRL4_CDT2_1	PIP motif of DTL	CRL4-Cdt2 binding PIP degron	This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4<sup>Cdt2</sup> ubiquitin ligase in a PCNA- and chromatin-dependent manner.	[NQ]{0,1}..[ILMV][ST][DEN][FY][FY].{2,3}[KR]{2,3}[^DE]
ELME000324	DEG_CRL4_CDT2_2	PIP 2nd motif of DTL	CRL4-Cdt2 binding PIP degron	This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4<sup>Cdt2</sup> ubiquitin ligase in a PCNA- and chromatin-dependent manner.	[NQ]{0,1}..[ILMV]T[DEN][HMFY][FMY].{2,3}[KR]{2,3}[^DE]
ELME000389	DEG_Kelch_actinfilin_1	KLHL17 motif	Actinfilin-binding degron	A hydrophobic degron motif present in some kainate receptors necessary to interact with kelch domain of actinfilin protein for efficient ubiquitination and degradation.	[AP]P[MV][IM]V
ELME000390	DEG_Kelch_Keap1_1	KEAP1 motif 1	KEAP1 binding degron	Motif that binds to the Kelch domain of KEAP1 with high affinity. This high affinity motif is required for the efficient recruitment of target proteins to the Cul3-based E3 ligase.	[DNS].[DES][TNS]GE
ELME000391	DEG_Kelch_Keap1_2	KEAP1 motif 2	KEAP1 binding degron	Motif that binds to the Kelch domain of KEAP1 with low affinity. This low affinity motif is important for ubiquitination and degradation of target proteins. 	QD.DLGV
ELME000392	DEG_Kelch_KLHL3_1	KLHL3/KLH2 motif	KLHL2 and KLHL3 binding degron	An Acidic degron motif present in wnk kinases necessary to interact with kelch domain of KLHL2 and KLHL3 proteins for efficient ubiquitination degradation.	E.EE.E[AV]DQH
ELME000184	DEG_MDM2_SWIB_1	MDM2 motif	MDM2 binding motif	An amphipatic &alpha;-helix found in p53 family members that binds in the hydrophobic cleft of MDM2's SWIB domain.	F[^P]{3}W[^P]{2,3}[VIL]
ELME000248	DEG_ODPH_VHL_1	VHL motif	Hydroxyproline modification in hypoxia signaling	Oxygen dependent prolyl hydroxylation motif in the unstructured region of hypoxia-inducible factor protein and bound by the VHL ligand.	[IL]A(P).{6,8}[FLIVM].[FLIVM]
ELME000350	DEG_SCF_COI1_1	SCF-LRR-degron	Phytohormone-dependent SCF-LRR-binding degrons	This degron motif is present in JAZ transcriptional repressor proteins and binds to the COI1 F-box protein of the SCF E3 ubiquitin ligase in a jasmonate-dependent manner.	..[RK][RK].SL..F[FLM].[RK]R[HRK].[RK].
ELME000289	DEG_SCF_FBW7_1	FBXW7 motif 1	SCF ubiquitin ligase binding Phosphodegrons	The TPxxS phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex.	[LIVMP].{0,2}(T)P..([ST])
ELME000292	DEG_SCF_FBW7_2	FBXW7 motif 2	SCF ubiquitin ligase binding Phosphodegrons	The TPxxE phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex.	[LIVMP].{0,2}(T)P..E
ELME000322	DEG_SCF_SKP2-CKS1_1	SKP2 Fbox motif	SCF ubiquitin ligase binding Phosphodegrons	Degradation motif recognised by a pre-assembled complex consisting of Skp2 (an F box protein of the SCF E3 ubiquitin ligase) and Cks1, which leads to ubiquitylation and subsequent proteosomal degradation.	..[DE].(T)P.K
ELME000347	DEG_SCF_TIR1_1	SCF-TIR1-degron	Phytohormone-dependent SCF-LRR-binding degrons	This degron motif is present in Aux/IAA transcriptional repressor proteins and binds to TIR1/AFB F-box proteins of the SCF E3 ubiquitin ligase in an auxin-dependent manner.	.[VLIA][VLI]GWPP[VLI]...R.
ELME000269	DEG_SCF_TRCP1_1	BTRCP motif	SCF ubiquitin ligase binding Phosphodegrons	The DSGxxS phospho-dependent degron binds the F box protein of the SCF-betaTrCP1 complex. The degron is found in various proteins that function in regulation of cell state.	D(S)G.{2,3}([ST])
ELME000241	DEG_SIAH_1	SIAH motif	Siah binding Motif	The PxAxVxP peptide binds to the substrate-binding domain (SBD) of the Siah family members	.P.A.V.P[^P]
ELME000388	DEG_SPOP_SBC_1	SPOP motif	SPOP SBC docking motif	The S/T rich motif known as the SPOP-binding consensus (SBC) of the MATH-BTB protein, SPOP, is present in substrates that undergo SPOP/Cul3-dependant ubiquitination.	[AVP].[ST][ST][ST]
ELME000435	LIG_APCC_ABBA_1	APC ABBA motif	APCC activator-binding ABBA motif	Amphipathic motif that is involved in APC/C inhibition by binding of CDH1/CDC20. In metazoan cyclin A, the motif also acts as a degron, enabling the cyclin's degradation in prometaphase.	[ILVMF].[ILMVP][FHY].[DE]
ELME000436	LIG_APCC_ABBAyCdc20_2	APC ABBA/Cdc20	APCC activator-binding ABBA motif	Amphipathic motif that binds to yeast Cdc20 and acts as an APC/C degron enabling cyclin Clb5 degradation during mitosis.	[KR]..[ILVM][FHY].[DE]
CBL1	CBL_PTK	CBL (PTK motif)	CBL PTK motif	degrons in cancer	[DN].{1,5}Y[ST]..P
CBL2	CBL_MET	CBL (MET motif)	CBL MET motif	degrons in cancer	DYR
SH2B	CBL_APS	CBL (APS motif)	CBL APS motif	degrons in cancer	RA[VI].NQY[ST]
ITCH	ITCH	ITCH motif	ITCH motif	degrons in cancer	PP.Y
SCF_FBXO31	SCF_FBXO31	FBX031 motif	FBX031 motif	ttp://www.pnas.org/content/early/2017/12/20/1708677115 PEST motif	PTDV[A-Z]{2}[VI][A-Z]{1}[IL]$
SCF_FBXL2	SCF_FBXL2	FBXL2 motif	FBXL2 motif	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133224/	[IL]{1}Q[A-Z]{0,3}RG[A-Z]{0,3}R
