4 Substructure mutations
32,997 substructure mutations (Gatekeeper, G-loop, αC-helix, and A-loop) associated with drug-response in 547 human protein kinases using 5 large-scale cancer datasets are in our database.
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Mutations
More than 679,000 Kinase mutation records were colloected from 5 large cancer genomics datasets: CCLE, GDSC, COSMIC, ICGC, and TCGA.
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Network-rewiring
251 522 records reflected that mutations on the phosphrylation sites have impacts on protein network-rewiring.
More>>Substructure
Kinase substructure (Gatekeeper, G-loop, αC-helix, A-loop) positions in human kinome.
Browse substructureNetwork-rewiring
Kinase network-rewiring mutations (gain, loss, up-regulation and down-regulation) analysis.
Network-rewiring mutationsDrug response
Pan-cancer kinome-wide drug response analysis from GDSC and CCLE database.
Browse drugsDrug resistance
Kinome-wide drug resistance analysis related to substructures from GDSC database.
Browse data3D structure
Gatekeeper
A-loop
G-loop
αC-helix
Quick stats
547 human protein kinases.
388 kinases with mutations in the four kinds of substructures.
180,856 amino acid position-unique mutations that were curated from 5 pan-cancer datasets.
32,997 substructure mutations that may be associated with drug response are in our database.
390,460 drug response records that are associated with human kinases were collected from CCLE and GDSC for pan-cancer.
534,457 experimentally identified protein phosphorylation sites were collected from EPSD.
19,653 substrates and cognate kinases records curated from PhosphoSitePlus.
251,522 predicted kinase regulation network-rewiring events for 296 kinases.
388 kinases with mutations in the four kinds of substructures.
180,856 amino acid position-unique mutations that were curated from 5 pan-cancer datasets.
32,997 substructure mutations that may be associated with drug response are in our database.
390,460 drug response records that are associated with human kinases were collected from CCLE and GDSC for pan-cancer.
534,457 experimentally identified protein phosphorylation sites were collected from EPSD.
19,653 substrates and cognate kinases records curated from PhosphoSitePlus.
251,522 predicted kinase regulation network-rewiring events for 296 kinases.
Updates
Aug 18, 2020: Kaplan plots for survival analysis were added to the database.
Jul 14, 2020: Update of substructure mutation data.
Jun 12, 2020: Bugs were fixed for showing the 3D structures.
May 12, 2020: Database website was constructed.
Mar 10, 2020: Drug responses data were re-processed.
Feb 26, 2020: Prediction of kinase regulatory network-rewring were done.
Feb 06, 2020: Experimentally identified protein phosphorylation sites, substrates and cognate kinases information were collected.
Jan 26, 2020: Latest mutation data were downloaded and re-processed for all kinases.
Aug 10, 2019: Group, family, and sub-family information were annoted.
Aug 01, 2019: Kinase list was extended by integrating protein kinases from UniProtKB.
May 12, 2019: The basic annotation for each kinase was done.
Mar 26, 2019: Mutation data were processed and mapped to the substructure loci.
Mar 07, 2019: Somatic mutations were downloaded from TCGA and COSMIC.
Mar 02, 2019: Kinase protein sequence were downloaded.
Feb 26, 2019: Four kinds of substructral locations were defined.
Feb 12, 2019: 538 human kinase proteins were collected from KinBase.
Jul 14, 2020: Update of substructure mutation data.
Jun 12, 2020: Bugs were fixed for showing the 3D structures.
May 12, 2020: Database website was constructed.
Mar 10, 2020: Drug responses data were re-processed.
Feb 26, 2020: Prediction of kinase regulatory network-rewring were done.
Feb 06, 2020: Experimentally identified protein phosphorylation sites, substrates and cognate kinases information were collected.
Jan 26, 2020: Latest mutation data were downloaded and re-processed for all kinases.
Aug 10, 2019: Group, family, and sub-family information were annoted.
Aug 01, 2019: Kinase list was extended by integrating protein kinases from UniProtKB.
May 12, 2019: The basic annotation for each kinase was done.
Mar 26, 2019: Mutation data were processed and mapped to the substructure loci.
Mar 07, 2019: Somatic mutations were downloaded from TCGA and COSMIC.
Mar 02, 2019: Kinase protein sequence were downloaded.
Feb 26, 2019: Four kinds of substructral locations were defined.
Feb 12, 2019: 538 human kinase proteins were collected from KinBase.
Developers:
Ruifeng Hu, Haodong Xu, Peilin Jia, Zhongming Zhao @ CPH, SBMI, UTHealth-Houston.
Citation of the Database:
Ruifeng Hu, Haodong Xu, Peilin Jia, Zhongming Zhao, KinaseMD: kinase mutations and drug response database, Nucleic Acids Research, gkaa945, https://doi.org/10.1093/nar/gkaa945.