mutLBSgeneDB |
Gene summary for SNUPN |
Gene summary |
Basic gene Info. | Gene symbol | SNUPN |
Gene name | snurportin 1 | |
Synonyms | KPNBL|RNUT1|Snurportin1 | |
Cytomap | UCSC genome browser: 15q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001042581.1, NM_001042588.1,NM_005701.3, | |
Description | RNA U transporter 1RNA, U transporter 1snurportin-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607902 | |
HGNC : HGNC | ||
Ensembl : ENSG00000169371 | ||
HPRD : 07441 | ||
Vega : OTTHUMG00000142833 | ||
Protein | UniProt: O95149 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SNUPN | |
BioGPS: 10073 | ||
Pathway | NCI Pathway Interaction Database: SNUPN | |
KEGG: SNUPN | ||
REACTOME: SNUPN | ||
Pathway Commons: SNUPN | ||
Context | iHOP: SNUPN | |
ligand binding site mutation search in PubMed: SNUPN | ||
UCL Cancer Institute: SNUPN | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for SNUPN |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | W276 | W276S | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SNUPN |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | W276 | W276S | -1.2902709 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for SNUPN from PDB |
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Differential gene expression and gene-gene network for SNUPN |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for SNUPN |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SNUPN |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of SNUPN go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | TPG | 2,2,7-TRIMETHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE | 1xk5 | A | W276 | PRO | L-PROLINE | 5dis | C | W276 |
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Conservation information for LBS of SNUPN |
Multiple alignments for O95149 in multiple species |
LBS | AA sequence | # species | Species | D255 | FPFEVDGLLFY | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | E106 | QLMLSEWLIDV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E106 | QLMLSEWLVDV | 1 | Gallus gallus | G127 | VVCPVGKRALI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G127 | VVCPVGKRALV | 1 | Gallus gallus | G127 | VVCPVGKRSLI | 1 | Bos taurus | K128 | VCPVGKRALIV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K128 | VCPVGKRALVV | 1 | Gallus gallus | K128 | VCPVGKRSLIV | 1 | Bos taurus | K144 | TSAYTKSGYCV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K144 | TAAYTKSGFCV | 1 | Gallus gallus | L258 | EVDGLLFYHKQ | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | R129 | CPVGKRALIVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R129 | CPVGKRALVVA | 1 | Gallus gallus | R129 | CPVGKRSLIVA | 1 | Bos taurus | S105 | NQLMLSEWLID | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S105 | NQLMLSEWLVD | 1 | Gallus gallus | W107 | LMLSEWLIDVP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W107 | LMLSEWLVDVP | 1 | Gallus gallus | W276 | TPLVGWLRPYM | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus |
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