mutLBSgeneDB |
Gene summary for ADAM8 |
Gene summary |
Basic gene Info. | Gene symbol | ADAM8 |
Gene name | ADAM metallopeptidase domain 8 | |
Synonyms | CD156|CD156a|MS2 | |
Cytomap | UCSC genome browser: 10q26.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001109.4, NM_001164489.1,NM_001164490.1, | |
Description | a disintegrin and metalloproteinase domain 8cell surface antigen MS2disintegrin and metalloproteinase domain-containing protein 8human leukocyte differentiation antigen | |
Modification date | 20141207 | |
dbXrefs | MIM : 602267 | |
HGNC : HGNC | ||
Ensembl : ENSG00000151651 | ||
HPRD : 03777 | ||
Vega : OTTHUMG00000019309 | ||
Protein | UniProt: P78325 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM8 | |
BioGPS: 101 | ||
Pathway | NCI Pathway Interaction Database: ADAM8 | |
KEGG: ADAM8 | ||
REACTOME: ADAM8 | ||
Pathway Commons: ADAM8 | ||
Context | iHOP: ADAM8 | |
ligand binding site mutation search in PubMed: ADAM8 | ||
UCL Cancer Institute: ADAM8 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006954 | inflammatory response | 17548643 | GO:0022407 | regulation of cell-cell adhesion | 17548643 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 15220135 | GO:0071456 | cellular response to hypoxia | 18566576 | GO:2000391 | positive regulation of neutrophil extravasation | 17548643 |
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Ligand binding site mutations for ADAM8 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | N398 | A397T | COAD | 1 | E335 | E335K | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ADAM8 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N398 | A397T | -0.81365782 | E335 | E335K | -0.66403765 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ADAM8 from PDB |
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Differential gene expression and gene-gene network for ADAM8 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ADAM8 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ADAM8 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ADAM8 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | BAT | BATIMASTAT | 4dd8 | A | E335 | BAT | BATIMASTAT | 4dd8 | B | E335 | BAT | BATIMASTAT | 4dd8 | C | E335 | BAT | BATIMASTAT | 4dd8 | D | E335 | CA | CALCIUM(2+) | 4dd8 | A | N398 | CA | CALCIUM(2+) | 4dd8 | B | N398 | CA | CALCIUM(2+) | 4dd8 | C | N398 | CA | CALCIUM(2+) | 4dd8 | D | N398 |
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Conservation information for LBS of ADAM8 |
Multiple alignments for P78325 in multiple species |
LBS | AA sequence | # species | Species |
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