mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPIF
Gene summary
Basic gene Info.Gene symbolPPIF
Gene namepeptidylprolyl isomerase F
SynonymsCYP3|CyP-M|Cyp-D|CypD
CytomapUCSC genome browser: 10q22-q23
Type of geneprotein-coding
RefGenesNM_005729.3,
DescriptionPPIase Fcyclophilin 3cyclophilin Dcyclophilin Fmitochondrial cyclophilinpeptidyl-prolyl cis-trans isomerase F, mitochondrialpeptidyl-prolyl cis-trans isomerase, mitochondrialrotamase F
Modification date20141207
dbXrefs MIM : 604486
HGNC : HGNC
Ensembl : ENSG00000108179
HPRD : 06839
Vega : OTTHUMG00000018562
ProteinUniProt: P30405
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPIF
BioGPS: 10105
PathwayNCI Pathway Interaction Database: PPIF
KEGG: PPIF
REACTOME: PPIF
Pathway Commons: PPIF
ContextiHOP: PPIF
ligand binding site mutation search in PubMed: PPIF
UCL Cancer Institute: PPIF
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0043066negative regulation of apoptotic process19228691
GO:0090201negative regulation of release of cytochrome c from mitochondria19228691


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Ligand binding site mutations for PPIF
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V70P72QLUAD1
R124P126SSKCM1
C203G204DSTAD1
N55N55YSTAD1
G89G89SUCEC1
S123G122RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPIF
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R124P126S-1.4426817
G89G89S-0.92582179
N55N55Y-0.90401076
V70P72Q-0.80818187
C203G204D-0.5493393
S123G122R-0.36125972
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPIF from PDB

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Differential gene expression and gene-gene network for PPIF
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPIF and the right PPI network was created from samples without mutations in the LBS of PPIF. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPIF
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0021831Intestinal Diseases1Biomarker
umls:C0041582Ulcer1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPIF
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigational|vet_approvedDB00091CyclosporineSmall molecule
Approved|nutraceuticalDB00172L-ProlineSmall molecule
ExperimentalDB020781-Methoxy-2-[2-(2-Methoxy-Ethoxy]-EthaneSmall molecule
ExperimentalDB081687-AMINO-4-METHYL-CHROMEN-2-ONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPIF go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MIO5-AMINO-3-METHYLISOXAZOLE3rdaXC203
MIO5-AMINO-3-METHYLISOXAZOLE3rdaXG89
4SO4-SULFAMOYLBENZOIC ACID3r4gAN55
Q8A8-AMINOQUINOLINE3r49AR124
6AI6-AMINOINDAZOLE3r56AR124
N3M3'-AMINOACETANILIDE3r57AR124
3AO3-ACETYLANILINE3r59AR124
M3I5-METHYL-1,2-OXAZOL-3-AMINE3rciXR124
5AO3-(1,3-OXAZOL-5-YL)ANILINE3rclAR124
MIO5-AMINO-3-METHYLISOXAZOLE3rdaXR124
5MZ3-(5-CHLOROMETHYL-[1,2,4]OXADIAZOL-3-YL)-ANILINE3rdbAR124
EA4ETHYL N-[(4-AMINOBENZYL)CARBAMOYL]GLYCINATE3rdcAR124
53Z1-(4-AMINOBENZYL)-3-[2-OXO-2-(PYRROLIDIN-1-YL) ETHYL]UREA4j58AR124
6711-(4-AMINOBENZYL)-3-{2-[(2R)-2-(NAPHTHALEN-1-YL) PYRROLIDIN-1-YL]-2-OXOETHYL}UREA4j59AR124
6B41-(4-AMINOBENZYL)-3-(2-{(2R)-2-[2-(METHYLSULFANYL) PHENYL]PYRROLIDIN-1-YL}-2-OXOETHYL)UREA4j5bAR124
7I61-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2- [2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN- 2-YL]UREA4j5cXR124
7281-(4-AMINOBENZYL)-3-{2-[(2R)-2-(2-BROMOPHENYL) PYRROLIDIN-1-YL]-2-OXOETHYL}UREA4j5dXR124
7B71-(4-AMINOBENZYL)-3-{2-[(2R)-2-(2-METHOXYPHENYL) PYRROLIDIN-1-YL]-2-OXOETHYL}UREA4j5eXR124
EA4ETHYL N-[(4-AMINOBENZYL)CARBAMOYL]GLYCINATE4xncAR124
EA4ETHYL N-[(4-AMINOBENZYL)CARBAMOYL]GLYCINATE4zscAR124
7I61-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2- [2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN- 2-YL]UREA4zsdAR124
1FPPIPERAZINE-1-CARBALDEHYDE3rckXV70


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Conservation information for LBS of PPIF
Multiple alignments for P30405 in multiple species
LBSAA sequence# speciesSpecies
A143GVLSMANAGPN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A143GLLSMANAGPN2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A143GFLSMANAGQD1Arabidopsis thaliana
A143GVLSMANSGED1Arabidopsis thaliana
A143GILSMANAGAN1Drosophila melanogaster
A145LSMANAGPNTN6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A145LSMANAGQDTN1Arabidopsis thaliana
A145LSMANSGEDTN1Arabidopsis thaliana
A145LSMANAGANTN1Drosophila melanogaster
A54YLDVGADGQPL3Bos taurus, Mus musculus, Rattus norvegicus
A54YLDVDANGKPL1Homo sapiens
A54YFDVEIDGKAA1Arabidopsis thaliana
A54YFDVEIDGKSA1Arabidopsis thaliana
A54FFDMTADNEPL1Drosophila melanogaster
A54YFDVEADGQPI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A54FFDVIANGQPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A68VLELKADVVPK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A68VMGLFGKTVPK1Arabidopsis thaliana
A68VIGLFGKAVPK1Arabidopsis thaliana
A68VMELRSDVVPK1Drosophila melanogaster
A68VFKLYNDIVPK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A68VFKLFDDVVPK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C203IVITDCGQLS-4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C203VVIVDSGELPL1Arabidopsis thaliana
C203VVIADSGELPL1Arabidopsis thaliana
C203IIVANSGSL--1Drosophila melanogaster
C203IVVAKSGEL--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C203IVIDKCGTV--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C82NFRALCTGEKG9Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D69LELKADVVPKT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D69MGLFGKTVPKT1Arabidopsis thaliana
D69IGLFGKAVPKT1Arabidopsis thaliana
D69MELRSDVVPKT1Drosophila melanogaster
D69FKLYNDIVPKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D69FKLFDDVVPKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F102RVIPSFMCQAG2Homo sapiens, Bos taurus
F102RVIPAFMCQAG2Mus musculus, Rattus norvegicus
F102RIIPSFMLQGG1Arabidopsis thaliana
F102RIIPSFMIQGG1Arabidopsis thaliana
F102RVIPNFMCQGG1Drosophila melanogaster
F102RVIPDFMLQGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F102RVIPQFMLQGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F155NGSQFFICTIK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F155NGSQFFITTVT2Arabidopsis thaliana, Arabidopsis thaliana
F155NGSQFFICTVK1Drosophila melanogaster
F155NGSQFFITTVP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F155NGSQFFITTVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F88TGEKGFG----6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F88TGEKGIGKNGK1Arabidopsis thaliana
F88TGEKGVGKSGK1Arabidopsis thaliana
F88TGEKGYG----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G114FTNHNGTGGKS4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
G114FTHGNGMGGES2Arabidopsis thaliana, Arabidopsis thaliana
G114FTNHNGTGGRS1Mus musculus
G114FTAGNGTGGKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G114FTRGNGTGGKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G116NHNGTGGKSIY4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
G116HGNGMGGESIY2Arabidopsis thaliana, Arabidopsis thaliana
G116NHNGTGGRSIY1Mus musculus
G116AGNGTGGKSIY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G116RGNGTGGKSIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G117HNGTGGKSIYG4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
G117GNGMGGESIYG2Arabidopsis thaliana, Arabidopsis thaliana
G117GNGTGGKSIYG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G117HNGTGGRSIYG1Mus musculus
G136TLKHVGPGVLS3Homo sapiens, Mus musculus, Rattus norvegicus
G136KLKHTGPGFLS1Arabidopsis thaliana
G136KLKHTGPGVLS1Arabidopsis thaliana
G136ELKHTGSGILS1Drosophila melanogaster
G136KLKHEGPGVLS1Bos taurus
G136KKHHDRPGLLS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G136ALKHNKPGLLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G138KHVGPGVLSMA3Homo sapiens, Mus musculus, Rattus norvegicus
G138KHTGPGFLSMA1Arabidopsis thaliana
G138KHTGPGVLSMA1Arabidopsis thaliana
G138KHTGSGILSMA1Drosophila melanogaster
G138KHEGPGVLSMA1Bos taurus
G138HHDRPGLLSMA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G138KHNKPGLLSMA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G146SMANAGPNTNG6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G146SMANAGQDTNG1Arabidopsis thaliana
G146SMANSGEDTNG1Arabidopsis thaliana
G146SMANAGANTNG1Drosophila melanogaster
G151GPNTNGSQFFI6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G151GQDTNGSQFFI1Arabidopsis thaliana
G151GEDTNGSQFFI1Arabidopsis thaliana
G151GANTNGSQFFI1Drosophila melanogaster
G44SSSSSGNPLVY2Homo sapiens, Bos taurus
G44ENLKEITHKVY1Arabidopsis thaliana
G44EDLKEVTHKVY1Arabidopsis thaliana
G44ASKMSTLPRVF1Drosophila melanogaster
G44ANSSSGNPLVY1Mus musculus
G44ANSSSQNPLVY1Rattus norvegicus
G44------MSQVY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G44------MSNCF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G84RALCTGEKGFG6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G84RALCTGEKGIG1Arabidopsis thaliana
G84RALCTGEKGVG1Arabidopsis thaliana
G84RALCTGEKGYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G87CTGEKGFG---6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G87CTGEKGIGKNG1Arabidopsis thaliana
G87CTGEKGVGKSG1Arabidopsis thaliana
G87CTGEKGYG---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G89GEKGFG-----6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G89GEKGIGKNGKA1Arabidopsis thaliana
G89GEKGVGKSGKP1Arabidopsis thaliana
G89GEKGYG-----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H168WLDGKHVVFGH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H168WLDGRHVVFGK2Arabidopsis thaliana, Arabidopsis thaliana
H168WLDGKHVVFGE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H168WLDNKHVVFGE1Drosophila melanogaster
H96KGSTFHRVIPS2Homo sapiens, Bos taurus
H96KGSTFHRVIPA2Mus musculus, Rattus norvegicus
H96KGSSFHRIIPS1Arabidopsis thaliana
H96KGSKFHRIIPS1Arabidopsis thaliana
H96KGSIFHRVIPN1Drosophila melanogaster
H96AGSPFHRVIPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H96AGSTFHRVIPQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I159FFICTIKTDWL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I159FFITTVTTSWL2Arabidopsis thaliana, Arabidopsis thaliana
I159FFICTVKTAWL1Drosophila melanogaster
I159FFITTVPCPWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I159FFITTVVTPWL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I99TFHRVIPSFMC2Homo sapiens, Bos taurus
I99TFHRVIPAFMC2Mus musculus, Rattus norvegicus
I99SFHRIIPSFML1Arabidopsis thaliana
I99KFHRIIPSFMI1Arabidopsis thaliana
I99IFHRVIPNFMC1Drosophila melanogaster
I99PFHRVIPDFML1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I99TFHRVIPQFML1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K167DWLDGKHVVFG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K167SWLDGRHVVFG2Arabidopsis thaliana, Arabidopsis thaliana
K167PWLDGKHVVFG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K167AWLDNKHVVFG1Drosophila melanogaster
K183MDVVKKIESFG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K183MDVVYKVEAEG1Arabidopsis thaliana
K183MDVVYKIEAEG1Arabidopsis thaliana
K183LDVVKKIESYG1Drosophila melanogaster
K183YDIVKKVESLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K183MDVVKKVESLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K196SGKTSKKIVIT3Bos taurus, Mus musculus, Rattus norvegicus
K196SGRTSKKIVIT1Homo sapiens
K196SGTPKSKVVIV1Arabidopsis thaliana
K196SGTPKSKVVIA1Arabidopsis thaliana
K196SGKTSKKIIVA1Drosophila melanogaster
K196SGATKARIVVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K196SGATRARIVID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K57VGADGQPLGRV3Bos taurus, Mus musculus, Rattus norvegicus
K57VDANGKPLGRV1Homo sapiens
K57VEIDGKAAGRI1Arabidopsis thaliana
K57VEIDGKSAGRV1Arabidopsis thaliana
K57MTADNEPLGRI1Drosophila melanogaster
K57VEADGQPIGRV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K57VIANGQPLGRI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K67VVLELKADVVP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K67IVMGLFGKTVP1Arabidopsis thaliana
K67VVIGLFGKAVP1Arabidopsis thaliana
K67IVMELRSDVVP1Drosophila melanogaster
K67VVFKLYNDIVP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K67IVFKLFDDVVP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K91----YKGSTFH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K91KALHYKGSSFH1Arabidopsis thaliana
K91KPLHYKGSKFH1Arabidopsis thaliana
K91----YKGSIFH1Drosophila melanogaster
K91----YAGSPFH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K91----YAGSTFH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L164IKTDWLDGKHV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L164VTTSWLDGRHV2Arabidopsis thaliana, Arabidopsis thaliana
L164VKTAWLDNKHV1Drosophila melanogaster
L164VPCPWLDGKHV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L164VVTPWLDGKHV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L59ADGQPLGRVVL3Bos taurus, Mus musculus, Rattus norvegicus
L59ANGKPLGRVVL1Homo sapiens
L59IDGKAAGRIVM1Arabidopsis thaliana
L59IDGKSAGRVVI1Arabidopsis thaliana
L59ADNEPLGRIVM1Drosophila melanogaster
L59ADGQPIGRVVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L59ANGQPLGRIVF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M103VIPSFMCQAGD2Homo sapiens, Bos taurus
M103VIPAFMCQAGD2Mus musculus, Rattus norvegicus
M103IIPSFMLQGGD1Arabidopsis thaliana
M103IIPSFMIQGGD1Arabidopsis thaliana
M103VIPNFMCQGGD1Drosophila melanogaster
M103VIPDFMLQGGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M103VIPQFMLQGGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N113DFTNHNGTGGK4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
N113DFTHGNGMGGE2Arabidopsis thaliana, Arabidopsis thaliana
N113DFTNHNGTGGR1Mus musculus
N113DFTAGNGTGGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N113DFTRGNGTGGK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N144VLSMANAGPNT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N144LLSMANAGPNT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N144FLSMANAGQDT1Arabidopsis thaliana
N144VLSMANSGEDT1Arabidopsis thaliana
N144ILSMANAGANT1Drosophila melanogaster
N45SSSSGNPLVYL2Homo sapiens, Bos taurus
N45NLKEITHKVYF1Arabidopsis thaliana
N45DLKEVTHKVYF1Arabidopsis thaliana
N45SKMSTLPRVFF1Drosophila melanogaster
N45NSSSGNPLVYL1Mus musculus
N45NSSSQNPLVYL1Rattus norvegicus
N45-----MSQVYF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N45-----MSNCFF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N55LDVGADGQPLG3Bos taurus, Mus musculus, Rattus norvegicus
N55LDVDANGKPLG1Homo sapiens
N55FDVEIDGKAAG1Arabidopsis thaliana
N55FDVEIDGKSAG1Arabidopsis thaliana
N55FDMTADNEPLG1Drosophila melanogaster
N55FDVEADGQPIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N55FDVIANGQPLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P137LKHVGPGVLSM3Homo sapiens, Mus musculus, Rattus norvegicus
P137LKHTGPGFLSM1Arabidopsis thaliana
P137LKHTGPGVLSM1Arabidopsis thaliana
P137LKHTGSGILSM1Drosophila melanogaster
P137LKHEGPGVLSM1Bos taurus
P137KHHDRPGLLSM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P137LKHNKPGLLSM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P147MANAGPNTNGS6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P147MANAGQDTNGS1Arabidopsis thaliana
P147MANSGEDTNGS1Arabidopsis thaliana
P147MANAGANTNGS1Drosophila melanogaster
Q105PSFMCQAGDFT2Homo sapiens, Bos taurus
Q105PAFMCQAGDFT2Mus musculus, Rattus norvegicus
Q105PSFMLQGGDFT1Arabidopsis thaliana
Q105PSFMIQGGDFT1Arabidopsis thaliana
Q105PNFMCQGGDFT1Drosophila melanogaster
Q105PDFMLQGGDFT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q105PQFMLQGGDFT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q153NTNGSQFFICT5Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus
Q153DTNGSQFFITT2Arabidopsis thaliana, Arabidopsis thaliana
Q153NTNGSQFFITT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R124SIYGSRFPDEN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R124SIYGEKFADEN1Arabidopsis thaliana
R124SIYGQKFADEN1Arabidopsis thaliana
R124SIYGNKFPDEN1Drosophila melanogaster
R124SIYGGKFPDEN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R124SIYGEKFPDEN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R97GSTFHRVIPSF2Homo sapiens, Bos taurus
R97GSTFHRVIPAF2Mus musculus, Rattus norvegicus
R97GSSFHRIIPSF1Arabidopsis thaliana
R97GSKFHRIIPSF1Arabidopsis thaliana
R97GSIFHRVIPNF1Drosophila melanogaster
R97GSPFHRVIPDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R97GSTFHRVIPQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S101HRVIPSFMCQA2Homo sapiens, Bos taurus
S101HRVIPAFMCQA2Mus musculus, Rattus norvegicus
S101HRIIPSFMLQG1Arabidopsis thaliana
S101HRIIPSFMIQG1Arabidopsis thaliana
S101HRVIPNFMCQG1Drosophila melanogaster
S101HRVIPDFMLQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S101HRVIPQFMLQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S123KSIYGSRFPDE3Homo sapiens, Bos taurus, Rattus norvegicus
S123ESIYGEKFADE1Arabidopsis thaliana
S123ESIYGQKFADE1Arabidopsis thaliana
S123KSIYGNKFPDE1Drosophila melanogaster
S123RSIYGSRFPDE1Mus musculus
S123KSIYGGKFPDE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S123KSIYGEKFPDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T115TNHNGTGGKSI4Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus
T115THGNGMGGESI2Arabidopsis thaliana, Arabidopsis thaliana
T115TNHNGTGGRSI1Mus musculus
T115TAGNGTGGKSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T115TRGNGTGGKSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T149NAGPNTNGSQF6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T149NAGQDTNGSQF1Arabidopsis thaliana
T149NSGEDTNGSQF1Arabidopsis thaliana
T149NAGANTNGSQF1Drosophila melanogaster
T83FRALCTGEKGF6Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T83FRALCTGEKGI1Arabidopsis thaliana
T83FRALCTGEKGV1Arabidopsis thaliana
T83FRALCTGEKGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V135FTLKHVGPGVL3Homo sapiens, Mus musculus, Rattus norvegicus
V135FKLKHTGPGFL1Arabidopsis thaliana
V135FKLKHTGPGVL1Arabidopsis thaliana
V135FELKHTGSGIL1Drosophila melanogaster
V135FKLKHEGPGVL1Bos taurus
V135FKKHHDRPGLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V135FALKHNKPGLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V139HVGPGVLSMAN3Homo sapiens, Mus musculus, Rattus norvegicus
V139HTGPGFLSMAN1Arabidopsis thaliana
V139HTGPGVLSMAN1Arabidopsis thaliana
V139HTGSGILSMAN1Drosophila melanogaster
V139HEGPGVLSMAN1Bos taurus
V139HDRPGLLSMAN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V139HNKPGLLSMAN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V70ELKADVVPKTA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V70GLFGKTVPKTV1Arabidopsis thaliana
V70GLFGKAVPKTA1Arabidopsis thaliana
V70ELRSDVVPKTA1Drosophila melanogaster
V70KLYNDIVPKTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V70KLFDDVVPKTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W163TIKTDWLDGKH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W163TVTTSWLDGRH2Arabidopsis thaliana, Arabidopsis thaliana
W163TVKTAWLDNKH1Drosophila melanogaster
W163TVPCPWLDGKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W163TVVTPWLDGKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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