mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TRAP1
Gene summary
Basic gene Info.Gene symbolTRAP1
Gene nameTNF receptor-associated protein 1
SynonymsHSP 75|HSP75|HSP90L|TRAP-1
CytomapUCSC genome browser: 16p13.3
Type of geneprotein-coding
RefGenesNM_001272049.1,
NM_016292.2,
DescriptionTNFR-associated protein 1heat shock protein 75 kDa, mitochondrialtumor necrosis factor type 1 receptor-associated protein
Modification date20141207
dbXrefs MIM : 606219
HGNC : HGNC
Ensembl : ENSG00000126602
HPRD : 05868
Vega : OTTHUMG00000129427
ProteinUniProt: Q12931
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TRAP1
BioGPS: 10131
PathwayNCI Pathway Interaction Database: TRAP1
KEGG: TRAP1
REACTOME: TRAP1
Pathway Commons: TRAP1
ContextiHOP: TRAP1
ligand binding site mutation search in PubMed: TRAP1
UCL Cancer Institute: TRAP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TRAP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
N171S170CBRCA1
E115R114WSTAD1
N119,A123S121IUCEC1
R402R402WUCEC1
S178S178LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TRAP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S178S178L0.92268922
N171S170C0.005279188
A123S121I-0.5687662
N119S121I-0.5687662
E115R114W-0.48165936
R402R402W-0.044775095
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TRAP1 from PDB

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Differential gene expression and gene-gene network for TRAP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TRAP1 and the right PPI network was created from samples without mutations in the LBS of TRAP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TRAP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0242656Disease Progression1Biomarker
umls:C0029408Osteoarthritis1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TRAP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TRAP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
94M6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE4z1gAA123
ANPAMP-PNP4z1iAE115 N119 A123 N171 S178 R402
ANPAMP-PNP4z1iCE115 N119 A123 N171 S178 R402
ANPAMP-PNP4z1iDE115 N119 A123 N171 S178 R402
H718-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE4z1fAN119 A123 N171
4KP8-[(6-IODO-1,3-BENZODIOXOL-5-YL)SULFANYL]-9-[6- (TRIPHENYL-LAMBDA~5~-PHOSPHANYL)HEXYL]-9H-PURIN-6- AMINE4z1hAN119 A123 N171
ANPAMP-PNP4z1iBN119 A123 N171 S178 R402


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Conservation information for LBS of TRAP1
Multiple alignments for Q12931 in multiple species
LBSAA sequence# speciesSpecies
A123SNASDALEKLR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D158TITIQDTGIGM3Homo sapiens, Mus musculus, Rattus norvegicus
D158TITIQDTGVGM1Bos taurus
E115EVFIRELISNA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E167GMTQEELVSNL2Homo sapiens, Mus musculus
E167GMSREELVSNL1Bos taurus
E167GMTKEELVSNL1Rattus norvegicus
F201KIIGQFGVGFY3Homo sapiens, Bos taurus, Mus musculus
F201RIIGQFGVGFY1Rattus norvegicus
F205QFGVGFYSAFM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G162QDTGIGMTQEE2Homo sapiens, Mus musculus
G162QDTGVGMSREE1Bos taurus
G162QDTGIGMTKEE1Rattus norvegicus
G179TIARSGSKAFL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G199SSKIIGQFGVG2Homo sapiens, Mus musculus
G199GSKIIGQFGVG1Bos taurus
G199SSRIIGQFGVG1Rattus norvegicus
G202IIGQFGVGFYS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G204GQFGVGFYSAF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I161IQDTGIGMTQE2Homo sapiens, Mus musculus
I161IQDTGVGMSRE1Bos taurus
I161IQDTGIGMTKE1Rattus norvegicus
K126SDALEKLRHKL3Homo sapiens, Bos taurus, Mus musculus
K126SDALEKLRHKR1Rattus norvegicus
L172ELVSNLGTIAR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M163DTGIGMTQEEL2Homo sapiens, Mus musculus
M163DTGVGMSREEL1Bos taurus
M163DTGIGMTKEEL1Rattus norvegicus
N119RELISNASDAL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N171EELVSNLGTIA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q200SKIIGQFGVGF3Homo sapiens, Bos taurus, Mus musculus
Q200SRIIGQFGVGF1Rattus norvegicus
R177LGTIARSGSKA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R402PLNLSRELLQE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S178GTIARSGSKAF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S180IARSGSKAFLD2Homo sapiens, Bos taurus
S180IARSGSKAFLE2Mus musculus, Rattus norvegicus
T251GVRTGTKIIIH2Homo sapiens, Bos taurus
T251GVRPGTKIIIH2Mus musculus, Rattus norvegicus
V203IGQFGVGFYSA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W231SPGYQWLSDGS2Mus musculus, Rattus norvegicus
W231SLGYQWLSDGS1Homo sapiens
W231SLGYRWLSDGS1Bos taurus


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