mutLBSgeneDB |
Gene summary for TRAP1 |
Gene summary |
Basic gene Info. | Gene symbol | TRAP1 |
Gene name | TNF receptor-associated protein 1 | |
Synonyms | HSP 75|HSP75|HSP90L|TRAP-1 | |
Cytomap | UCSC genome browser: 16p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001272049.1, NM_016292.2, | |
Description | TNFR-associated protein 1heat shock protein 75 kDa, mitochondrialtumor necrosis factor type 1 receptor-associated protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 606219 | |
HGNC : HGNC | ||
Ensembl : ENSG00000126602 | ||
HPRD : 05868 | ||
Vega : OTTHUMG00000129427 | ||
Protein | UniProt: Q12931 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRAP1 | |
BioGPS: 10131 | ||
Pathway | NCI Pathway Interaction Database: TRAP1 | |
KEGG: TRAP1 | ||
REACTOME: TRAP1 | ||
Pathway Commons: TRAP1 | ||
Context | iHOP: TRAP1 | |
ligand binding site mutation search in PubMed: TRAP1 | ||
UCL Cancer Institute: TRAP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for TRAP1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | N171 | S170C | BRCA | 1 | E115 | R114W | STAD | 1 | N119,A123 | S121I | UCEC | 1 | R402 | R402W | UCEC | 1 | S178 | S178L | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TRAP1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S178 | S178L | 0.92268922 | N171 | S170C | 0.005279188 | A123 | S121I | -0.5687662 | N119 | S121I | -0.5687662 | E115 | R114W | -0.48165936 | R402 | R402W | -0.044775095 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for TRAP1 from PDB |
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Differential gene expression and gene-gene network for TRAP1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for TRAP1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0242656 | Disease Progression | 1 | Biomarker |
umls:C0029408 | Osteoarthritis | 1 | Biomarker |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TRAP1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of TRAP1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 94M | 6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE | 4z1g | A | A123 | ANP | AMP-PNP | 4z1i | A | E115 N119 A123 N171 S178 R402 | ANP | AMP-PNP | 4z1i | C | E115 N119 A123 N171 S178 R402 | ANP | AMP-PNP | 4z1i | D | E115 N119 A123 N171 S178 R402 | H71 | 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)THIO]-9-[3-(ISOPROPYLAMINO)PROPYL]-9H-PURIN-6-AMINE | 4z1f | A | N119 A123 N171 | 4KP | 8-[(6-IODO-1,3-BENZODIOXOL-5-YL)SULFANYL]-9-[6- (TRIPHENYL-LAMBDA~5~-PHOSPHANYL)HEXYL]-9H-PURIN-6- AMINE | 4z1h | A | N119 A123 N171 | ANP | AMP-PNP | 4z1i | B | N119 A123 N171 S178 R402 |
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Conservation information for LBS of TRAP1 |
Multiple alignments for Q12931 in multiple species |
LBS | AA sequence | # species | Species | A123 | SNASDALEKLR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D158 | TITIQDTGIGM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D158 | TITIQDTGVGM | 1 | Bos taurus | E115 | EVFIRELISNA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E167 | GMTQEELVSNL | 2 | Homo sapiens, Mus musculus | E167 | GMSREELVSNL | 1 | Bos taurus | E167 | GMTKEELVSNL | 1 | Rattus norvegicus | F201 | KIIGQFGVGFY | 3 | Homo sapiens, Bos taurus, Mus musculus | F201 | RIIGQFGVGFY | 1 | Rattus norvegicus | F205 | QFGVGFYSAFM | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G162 | QDTGIGMTQEE | 2 | Homo sapiens, Mus musculus | G162 | QDTGVGMSREE | 1 | Bos taurus | G162 | QDTGIGMTKEE | 1 | Rattus norvegicus | G179 | TIARSGSKAFL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G199 | SSKIIGQFGVG | 2 | Homo sapiens, Mus musculus | G199 | GSKIIGQFGVG | 1 | Bos taurus | G199 | SSRIIGQFGVG | 1 | Rattus norvegicus | G202 | IIGQFGVGFYS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G204 | GQFGVGFYSAF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I161 | IQDTGIGMTQE | 2 | Homo sapiens, Mus musculus | I161 | IQDTGVGMSRE | 1 | Bos taurus | I161 | IQDTGIGMTKE | 1 | Rattus norvegicus | K126 | SDALEKLRHKL | 3 | Homo sapiens, Bos taurus, Mus musculus | K126 | SDALEKLRHKR | 1 | Rattus norvegicus | L172 | ELVSNLGTIAR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | M163 | DTGIGMTQEEL | 2 | Homo sapiens, Mus musculus | M163 | DTGVGMSREEL | 1 | Bos taurus | M163 | DTGIGMTKEEL | 1 | Rattus norvegicus | N119 | RELISNASDAL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N171 | EELVSNLGTIA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q200 | SKIIGQFGVGF | 3 | Homo sapiens, Bos taurus, Mus musculus | Q200 | SRIIGQFGVGF | 1 | Rattus norvegicus | R177 | LGTIARSGSKA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R402 | PLNLSRELLQE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S178 | GTIARSGSKAF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S180 | IARSGSKAFLD | 2 | Homo sapiens, Bos taurus | S180 | IARSGSKAFLE | 2 | Mus musculus, Rattus norvegicus | T251 | GVRTGTKIIIH | 2 | Homo sapiens, Bos taurus | T251 | GVRPGTKIIIH | 2 | Mus musculus, Rattus norvegicus | V203 | IGQFGVGFYSA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W231 | SPGYQWLSDGS | 2 | Mus musculus, Rattus norvegicus | W231 | SLGYQWLSDGS | 1 | Homo sapiens | W231 | SLGYRWLSDGS | 1 | Bos taurus |
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