mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for 101928916
Gene summary
Basic gene Info.Gene symbol101928916
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt: P40261
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_101928916
BioGPS: 101928916
PathwayNCI Pathway Interaction Database: 101928916
KEGG: 101928916
REACTOME: 101928916
Pathway Commons: 101928916
ContextiHOP: 101928916
ligand binding site mutation search in PubMed: 101928916
UCL Cancer Institute: 101928916
Assigned class in mutLBSgeneDB

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for 101928916

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for 101928916
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C141L139P-1.5806034
G63D61N-1.4089758
Y204M205T-1.2358818
G63G63D-1.1606107
D85D85G-1.1373302
Y25K26R-0.86499042
Y20D19N-0.81602399
Y11Y11C-0.77959695
A198A198V-0.76086613
N90L91Q-0.71771003
Y204I206L-0.16487276
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for 101928916 from PDB

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Differential gene expression and gene-gene network for 101928916
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of 101928916 and the right PPI network was created from samples without mutations in the LBS of 101928916. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for 101928916
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for 101928916
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigational|nutraceuticalDB00627NiacinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of 101928916 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SAHS-ADENOSYL-L-HOMOCYSTEINE3rodCY11 Y20 Y25 G63 D85 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE2iipAY11 Y20 Y25 G63 D85 N90 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE2iipBY11 Y20 Y25 G63 D85 N90 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE2iipCY11 Y20 Y25 G63 D85 N90 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE2iipDY11 Y20 Y25 G63 D85 N90 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE3rodAY11 Y20 Y25 G63 D85 N90 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE3rodBY11 Y20 Y25 G63 D85 N90 C141
SAHS-ADENOSYL-L-HOMOCYSTEINE3rodDY11 Y20 Y25 G63 D85 N90 C141
NCANICOTINAMIDE3rodAY20 A198 Y204
NCANICOTINAMIDE3rodBY20 Y204
NCANICOTINAMIDE3rodCY20 Y204
NCANICOTINAMIDE3rodDY20 Y204


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Conservation information for LBS of 101928916
Multiple alignments for P40261 in multiple species
LBSAA sequence# speciesSpecies


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