mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CDK9
Gene summary
Basic gene Info.Gene symbolCDK9
Gene namecyclin-dependent kinase 9
SynonymsC-2k|CDC2L4|CTK1|PITALRE|TAK
CytomapUCSC genome browser: 9q34.1
Type of geneprotein-coding
RefGenesNM_001261.3,
DescriptionCDC2-related kinasecell division cycle 2-like protein kinase 4cell division protein kinase 9serine/threonine protein kinase PITALREtat-associated kinase complex catalytic subunit
Modification date20141207
dbXrefs MIM : 603251
HGNC : HGNC
Ensembl : ENSG00000136807
HPRD : 16016
Vega : OTTHUMG00000020715
ProteinUniProt: P50750
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CDK9
BioGPS: 1025
PathwayNCI Pathway Interaction Database: CDK9
KEGG: CDK9
REACTOME: CDK9
Pathway Commons: CDK9
ContextiHOP: CDK9
ligand binding site mutation search in PubMed: CDK9
UCL Cancer Institute: CDK9
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006282regulation of DNA repair20493174
GO:0006468protein phosphorylation16109376
GO:0031056regulation of histone modification19844166
GO:0043111replication fork arrest20930849
GO:0071157negative regulation of cell cycle arrest20930849
GO:0071345cellular response to cytokine stimulus17956865


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Ligand binding site mutations for CDK9
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E66R65LLUAD1
A166L165MSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CDK9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A166L165M-0.96825218
E66R65L-0.057599146
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDK9 from PDB

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Differential gene expression and gene-gene network for CDK9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CDK9 and the right PPI network was created from samples without mutations in the LBS of CDK9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CDK9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CDK9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Experimental|investigationalDB03496FlavopiridolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDK9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
F18CAN5083tn8AE66
F18CAN5083tnhAE66
AMPAMP4imyAE66 A166
AMPAMP4imyEE66 A166


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Conservation information for LBS of CDK9
Multiple alignments for P50750 in multiple species
LBSAA sequence# speciesSpecies
A153RDMKAANVLIT6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
A153RDLKAANLLID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A153RDMKAANVLIS1Caenorhabditis elegans
A166GVLKLADFGLA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
A166GILKIADFGLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A166GILKLADFGLA1Caenorhabditis elegans
A46TGQKVALKKVL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A46TGKKVALKKVL2Gallus gallus, Xenopus tropicalis
A46DGKVYALKRIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A46TGRMVALKKIL1Caenorhabditis elegans
C106LVFDFCEHDLA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
C106MVTPYMDHDLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C106LVMALCAHDLA1Caenorhabditis elegans
D104IYLVFDFCEHD5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus
D104IYMVTPYMDHD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D104FYLVMALCAHD1Caenorhabditis elegans
D104IFLVFDFCEHD1Xenopus tropicalis
D109DFCEHDLAGLL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
D109PYMDHDLSGLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D109ALCAHDLAGLL1Caenorhabditis elegans
D149KILHRDMKAAN7Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
D149LILHRDLKAAN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D167VLKLADFGLAR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
D167ILKIADFGLAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D167ILKLADFGLAR1Caenorhabditis elegans
E107VFDFCEHDLAG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
E107VTPYMDHDLSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E107VMALCAHDLAG1Caenorhabditis elegans
E32QGTFGEVFKAK5Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
E32QGTFGEVFKAR2Homo sapiens, Caenorhabditis elegans
E32EGTFGEVYKSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E66ITALREIKILQ6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
E66ITAIREIKILK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E66ITALREVKMLE1Caenorhabditis elegans
F103SIYLVFDFCEH5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus
F103SIYMVTPYMDH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F103TFYLVMALCAH1Caenorhabditis elegans
F103TIFLVFDFCEH1Xenopus tropicalis
F105YLVFDFCEHDL5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus
F105YMVTPYMDHDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F105YLVMALCAHDL1Caenorhabditis elegans
F105FLVFDFCEHDL1Xenopus tropicalis
F168LKLADFGLARA6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
F168LKIADFGLARV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F168LKLADFGLARP1Caenorhabditis elegans
F30IGQGTFGEVFK7Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
F30LGEGTFGEVYK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G169KLADFGLARAF6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
G169KIADFGLARVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G169KLADFGLARPF1Caenorhabditis elegans
G26KLAKIGQGTFG5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus
G26LMEKLGEGTFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G26KLNKIGQGTFG1Caenorhabditis elegans
G26RLAKIGQGTFG1Xenopus tropicalis
G28AKIGQGTFGEV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
G28EKLGEGTFGEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G28NKIGQGTFGEV1Caenorhabditis elegans
H108FDFCEHDLAGL6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
H108TPYMDHDLSGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H108MALCAHDLAGL1Caenorhabditis elegans
I25EKLAKIGQGTF5Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus
I25HLMEKLGEGTF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I25EKLNKIGQGTF1Caenorhabditis elegans
I25ERLAKIGQGTF1Xenopus tropicalis
K151LHRDMKAANVL7Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
K151LHRDLKAANLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K48QKVALKKVLME4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K48KKVALKKVLME2Gallus gallus, Xenopus tropicalis
K48KVYALKRILMH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K48RMVALKKILME1Caenorhabditis elegans
L156KAANVLITRDG6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
L156KAANLLIDNHG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L156KAANVLISKDG1Caenorhabditis elegans
L70REIKILQLLKH6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
L70REIKILKSIKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L70REVKMLEQLKH1Caenorhabditis elegans
N154DMKAANVLITR6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
N154DLKAANLLIDN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N154DMKAANVLISK1Caenorhabditis elegans
Q27LAKIGQGTFGE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
Q27MEKLGEGTFGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q27LNKIGQGTFGE1Caenorhabditis elegans
T29KIGQGTFGEVF7Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
T29KLGEGTFGEVY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V33GTFGEVFKAKH5Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
V33GTFGEVFKARH1Homo sapiens
V33GTFGEVYKSQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V33GTFGEVFKARC1Caenorhabditis elegans
V79KHENVVNLIEI6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Gallus gallus, Xenopus tropicalis
V79KHENIIPLSDM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V79KHPNITDLIEV1Caenorhabditis elegans


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