mutLBSgeneDB |
Gene summary for RAMP1 |
Gene summary |
Basic gene Info. | Gene symbol | RAMP1 |
Gene name | receptor (G protein-coupled) activity modifying protein 1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2q36-q37.1 | |
Type of gene | protein-coding | |
RefGenes | NM_005855.2, | |
Description | CRLR activity-modifying protein 1calcitonin receptor-like receptor activity modifying protein 1calcitonin-receptor-like receptor activity-modifying protein 1receptor (calcitonin) activity modifying protein 1receptor activity modifying protein 1recept | |
Modification date | 20141207 | |
dbXrefs | MIM : 605153 | |
HGNC : HGNC | ||
Ensembl : ENSG00000132329 | ||
HPRD : 05515 | ||
Vega : OTTHUMG00000133337 | ||
Protein | UniProt: O60894 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RAMP1 | |
BioGPS: 10267 | ||
Pathway | NCI Pathway Interaction Database: RAMP1 | |
KEGG: RAMP1 | ||
REACTOME: RAMP1 | ||
Pathway Commons: RAMP1 | ||
Context | iHOP: RAMP1 | |
ligand binding site mutation search in PubMed: RAMP1 | ||
UCL Cancer Institute: RAMP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0001525 | angiogenesis | 20596610 | GO:0006816 | calcium ion transport | 10882736 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway | 9620797 | GO:0015031 | protein transport | 10882736 | GO:0030819 | positive regulation of cAMP biosynthetic process | 10882736 | GO:0031623 | receptor internalization | 15613468 | GO:0060050 | positive regulation of protein glycosylation | 9620797 | GO:0072659 | protein localization to plasma membrane | 10882736 |
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Ligand binding site mutations for RAMP1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | W74 | T73I | KIRC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RAMP1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | W74 | T73I | -0.57040381 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for RAMP1 from PDB |
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Differential gene expression and gene-gene network for RAMP1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for RAMP1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RAMP1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB01278 | Pramlintide | Biotech |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of RAMP1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | N7R | N-[(3R,6S)-6-(2,3-DIFLUOROPHENYL)-2-OXO-1-(2,2,2-TRIFLUOROETHYL)AZEPAN-3-YL]-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-1-YL)PIPERIDINE-1-CARBOXAMIDE | 3n7r | C | W74 | 3N6 | OLCEGEPANT | 3n7r | D | W74 | 3N6 | OLCEGEPANT | 3n7s | D | W74 |
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Conservation information for LBS of RAMP1 |
Multiple alignments for O60894 in multiple species |
LBS | AA sequence | # species | Species | A70 | SYRELADCTWH | 1 | Homo sapiens | A70 | SYGELTYCTKH | 1 | Mus musculus | A70 | SYGELTHCTKL | 1 | Rattus norvegicus | D71 | YRELADCTWHM | 1 | Homo sapiens | D71 | YGELTYCTKHV | 1 | Mus musculus | D71 | YGELTHCTKLV | 1 | Rattus norvegicus | P85 | IGCFWPNPEVD | 2 | Mus musculus, Rattus norvegicus | P85 | LGCFWPNAEVD | 1 | Homo sapiens | R67 | TIRSYRELADC | 1 | Homo sapiens | R67 | TIQSYGELTYC | 1 | Mus musculus | R67 | TIGSYGELTHC | 1 | Rattus norvegicus | W74 | LADCTWHMAEK | 1 | Homo sapiens | W74 | LTYCTKHVAHT | 1 | Mus musculus | W74 | LTHCTKLVANK | 1 | Rattus norvegicus | W84 | KLGCFWPNAEV | 1 | Homo sapiens | W84 | TIGCFWPNPEV | 1 | Mus musculus | W84 | KIGCFWPNPEV | 1 | Rattus norvegicus |
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