mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CGRRF1
Gene summary
Basic gene Info.Gene symbolCGRRF1
Gene namecell growth regulator with ring finger domain 1
CytomapUCSC genome browser: 14q22.2
Type of geneprotein-coding
DescriptionRING finger protein 197cell growth regulator with RING finger domain protein 1cell growth regulatory gene 19 protein
Modification date20141207
dbXrefs MIM : 606138
HPRD : 09366
ProteinUniProt: Q99675
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CGRRF1
BioGPS: 10668
PathwayNCI Pathway Interaction Database: CGRRF1
Pathway Commons: CGRRF1
ContextiHOP: CGRRF1
ligand binding site mutation search in PubMed: CGRRF1
UCL Cancer Institute: CGRRF1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CGRRF1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CGRRF1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CGRRF1 from PDB

Differential gene expression and gene-gene network for CGRRF1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CGRRF1 and the right PPI network was created from samples without mutations in the LBS of CGRRF1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CGRRF1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CGRRF1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CGRRF1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CGRRF1
Multiple alignments for Q99675 in multiple species
LBSAA sequence# speciesSpecies
C274ENSKDCVVCQN1Homo sapiens
C274ESSRDCVVCQN1Mus musculus
C274ESSKDCVVCQN1Rattus norvegicus
C277KDCVVCQNGTV1Homo sapiens
C277RDCVVCQNGGV1Mus musculus
C277KDCVVCQNGGV1Rattus norvegicus
C289WVLLPCRHACL2Mus musculus, Rattus norvegicus
C289WVLLPCRHTCL1Homo sapiens
C295RHTCLCDGCVK1Homo sapiens
C295RHACLCDSCVR1Mus musculus
C295RHACLCDSCVC1Rattus norvegicus
C298CLCDGCVKYFQ1Homo sapiens
C298CLCDSCVRYFK1Mus musculus
C298CLCDSCVCYFK1Rattus norvegicus
C305KYFQQCPMCRQ1Homo sapiens
C305RYFKQCPMCRQ1Mus musculus
C305CYFKQCPMCRQ1Rattus norvegicus
C308KQCPMCRQFVQ2Mus musculus, Rattus norvegicus
C308QQCPMCRQFVQ1Homo sapiens
H291LLPCRHACLCD2Mus musculus, Rattus norvegicus
H291LLPCRHTCLCD1Homo sapiens

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