mutLBSgeneDB |
Gene summary for CGRRF1 |
Gene summary |
Basic gene Info. | Gene symbol | CGRRF1 |
Gene name | cell growth regulator with ring finger domain 1 | |
Synonyms | CGR19|RNF197 | |
Cytomap | UCSC genome browser: 14q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_006568.2, | |
Description | RING finger protein 197cell growth regulator with RING finger domain protein 1cell growth regulatory gene 19 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 606138 | |
HGNC : HGNC | ||
HPRD : 09366 | ||
Protein | UniProt: Q99675 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CGRRF1 | |
BioGPS: 10668 | ||
Pathway | NCI Pathway Interaction Database: CGRRF1 | |
KEGG: CGRRF1 | ||
REACTOME: CGRRF1 | ||
Pathway Commons: CGRRF1 | ||
Context | iHOP: CGRRF1 | |
ligand binding site mutation search in PubMed: CGRRF1 | ||
UCL Cancer Institute: CGRRF1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CGRRF1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C289 | C289Y | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CGRRF1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | C289 | C289Y | -0.88281001 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CGRRF1 from PDB |
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Differential gene expression and gene-gene network for CGRRF1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CGRRF1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CGRRF1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CGRRF1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CGRRF1 |
Multiple alignments for Q99675 in multiple species |
LBS | AA sequence | # species | Species | C274 | ENSKDCVVCQN | 1 | Homo sapiens | C274 | ESSRDCVVCQN | 1 | Mus musculus | C274 | ESSKDCVVCQN | 1 | Rattus norvegicus | C277 | KDCVVCQNGTV | 1 | Homo sapiens | C277 | RDCVVCQNGGV | 1 | Mus musculus | C277 | KDCVVCQNGGV | 1 | Rattus norvegicus | C289 | WVLLPCRHACL | 2 | Mus musculus, Rattus norvegicus | C289 | WVLLPCRHTCL | 1 | Homo sapiens | C295 | RHTCLCDGCVK | 1 | Homo sapiens | C295 | RHACLCDSCVR | 1 | Mus musculus | C295 | RHACLCDSCVC | 1 | Rattus norvegicus | C298 | CLCDGCVKYFQ | 1 | Homo sapiens | C298 | CLCDSCVRYFK | 1 | Mus musculus | C298 | CLCDSCVCYFK | 1 | Rattus norvegicus | C305 | KYFQQCPMCRQ | 1 | Homo sapiens | C305 | RYFKQCPMCRQ | 1 | Mus musculus | C305 | CYFKQCPMCRQ | 1 | Rattus norvegicus | C308 | KQCPMCRQFVQ | 2 | Mus musculus, Rattus norvegicus | C308 | QQCPMCRQFVQ | 1 | Homo sapiens | H291 | LLPCRHACLCD | 2 | Mus musculus, Rattus norvegicus | H291 | LLPCRHTCLCD | 1 | Homo sapiens |
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