mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TXNL4A
Gene summary
Basic gene Info.Gene symbolTXNL4A
Gene namethioredoxin-like 4A
SynonymsDIB1|DIM1|HsT161|SNRNP15|TXNL4|U5-15kD
CytomapUCSC genome browser: 18q23
Type of geneprotein-coding
RefGenesNM_006701.2,
DescriptionDIM1 protein homologspliceosomal U5 snRNP-specific 15 kDa proteinthioredoxin-like 4thioredoxin-like U5 snRNP protein U5-15kDthioredoxin-like protein 4A
Modification date20141207
dbXrefs MIM : 611595
HGNC : HGNC
HPRD : 18252
ProteinUniProt: P83876
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TXNL4A
BioGPS: 10907
PathwayNCI Pathway Interaction Database: TXNL4A
KEGG: TXNL4A
REACTOME: TXNL4A
Pathway Commons: TXNL4A
ContextiHOP: TXNL4A
ligand binding site mutation search in PubMed: TXNL4A
UCL Cancer Institute: TXNL4A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for TXNL4A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M91M91ICOAD1
M82V81ACOAD1
E74E74VLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TXNL4A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M82V81A-1.4448943
E74E74V-0.8400395
M91M91I-0.7384931
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TXNL4A from PDB

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Differential gene expression and gene-gene network for TXNL4A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TXNL4A and the right PPI network was created from samples without mutations in the LBS of TXNL4A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TXNL4A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TXNL4A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TXNL4A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (PRO,LEU,PHE,GLN,GLN,ARG,PRO,TYR,PRO,SER,PRO,GLY,ALA,VAL,LEU,ARG,ALA,ASN,ALA,GLU,ALA,SER,ARG)4bwqAE74 M82 M91
IIIPeptide ligand (PRO,LEU,PHE,GLN,GLN,ARG,PRO,TYR,PRO,SER,PRO,GLY,ALA,VAL,LEU,ARG,ALA,ASN,ALA,GLU,ALA,SER,ARG,THR,LYS,GLN)4bwqCE74 M82 M91
IIIPeptide ligand (PRO,LEU,PHE,GLN,GLN,ARG,PRO,TYR,PRO,SER,PRO,GLY,ALA,VAL,LEU,ARG,ALA,ASN,ALA,GLU,ALA,SER,ARG,THR,LYS)4bwqEE74 M82 M91
IIIPeptide ligand (PRO,LEU,PHE,GLN,GLN,ARG,PRO,TYR,PRO,SER,PRO,GLY,ALA,VAL,LEU,ARG,ALA,ASN,ALA,GLU,ALA,SER,ARG,THR,LYS,GLN)4bwqGE74 M82 M91
IIIPeptide ligand (PRO,LEU,PHE,GLN,GLN,ARG,PRO,TYR,PRO,SER,PRO,GLY,ALA,VAL,LEU,ARG,ALA,ASN,ALA,GLU,ALA,SER)4bwsAE74 M82 M91
IIIPeptide ligand (PRO,LEU,PHE,GLN,GLN,ARG,PRO,TYR,PRO,SER,PRO,GLY,ALA,VAL,LEU,ARG,ALA,ASN,ALA,GLU,ALA,SER,ARG)4bwsDE74 M82 M91


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Conservation information for LBS of TXNL4A
Multiple alignments for P83876 in multiple species
LBSAA sequence# speciesSpecies
D15NGWQVDQAILS2Homo sapiens, Mus musculus
D15SGWHVDQAILS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D15SGWAVDQSILA1Arabidopsis thaliana
D15TGWHVDQAIVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D15SGWHVDQAIVT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D68ITEVPDFNKMY2Homo sapiens, Mus musculus
D68IDEVPDFNKMY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D68ITEVPDFNTMY1Arabidopsis thaliana
D68IDEVSDFDEMY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D68TTEVPDFNEMY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E74FNKMYELYDPC2Homo sapiens, Mus musculus
E74FNKMYELYDRT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E74FNTMYELYDPS1Arabidopsis thaliana
E74FDEMYELTDPM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E74FNEMYELQDPM1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F69TEVPDFNKMYE2Homo sapiens, Mus musculus
F69DEVPDFNKMYE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F69TEVPDFNTMYE1Arabidopsis thaliana
F69DEVSDFDEMYE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F69TEVPDFNEMYE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F84CTVMFFFRNKH2Homo sapiens, Mus musculus
F84TTIMFFYRNKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F84STVMFFFRNKH1Arabidopsis thaliana
F84MTVMFFYHNKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F84MTVMFFYKNKH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G11PHLHNGWQVDQ2Homo sapiens, Mus musculus
G11PHLHSGWHVDQ2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G11PHLHSGWAVDQ1Arabidopsis thaliana
G11PQLRTGWHVDQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H89FFRNKHIMIDL3Homo sapiens, Mus musculus, Arabidopsis thaliana
H89FYRNKHMMIDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H89FYHNKHMMCDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H89FYKNKHMRCDF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I18QVDQAILSEED2Homo sapiens, Mus musculus
I18HVDQAILSEQE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I18AVDQSILAEEE1Arabidopsis thaliana
I18HVDQAIVTETK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I18HVDQAIVTEEE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K101TGNNNKINWAM2Homo sapiens, Mus musculus
K101TGNNNKINWPL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K101TGNNNKINWAL1Arabidopsis thaliana
K101TGNNNKLNFIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K101TGNNNKMNFVV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M72PDFNKMYELYD3Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus
M72PDFNTMYELYD1Arabidopsis thaliana
M72SDFDEMYELTD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M72PDFNEMYELQD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M82DPCTVMFFFRN2Homo sapiens, Mus musculus
M82DRTTIMFFYRN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M82DPSTVMFFFRN1Arabidopsis thaliana
M82DPMTVMFFYHN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M82DPMTVMFFYKN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M91RNKHIMIDLGT3Homo sapiens, Mus musculus, Arabidopsis thaliana
M91RNKHMMIDLGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M91HNKHMMCDFGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M91KNKHMRCDFGT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N100GTGNNNKINWA3Homo sapiens, Mus musculus, Arabidopsis thaliana
N100GTGNNNKINWP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N100GTGNNNKLNFI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N100GTGNNNKMNFV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N87MFFFRNKHIMI3Homo sapiens, Mus musculus, Arabidopsis thaliana
N87MFFYRNKHMMI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N87MFFYHNKHMMC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N87MFFYKNKHMRC1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N98DLGTGNNNKIN4Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Arabidopsis thaliana
N98DFGTGNNNKLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N98DFGTGNNNKMN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N99LGTGNNNKINW4Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Arabidopsis thaliana
N99FGTGNNNKLNF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N99FGTGNNNKMNF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V14HNGWQVDQAIL2Homo sapiens, Mus musculus
V14HSGWHVDQAIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V14HSGWAVDQSIL1Arabidopsis thaliana
V14RTGWHVDQAIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V14HSGWHVDQAIV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y73DFNKMYELYDP2Homo sapiens, Mus musculus
Y73DFNKMYELYDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y73DFNTMYELYDP1Arabidopsis thaliana
Y73DFDEMYELTDP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y73DFNEMYELQDP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)


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