mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STIP1
Gene summary
Basic gene Info.Gene symbolSTIP1
Gene namestress-induced phosphoprotein 1
SynonymsHEL-S-94n|HOP|IEF-SSP-3521|P60|STI1|STI1L
CytomapUCSC genome browser: 11q13
Type of geneprotein-coding
RefGenesNM_001282652.1,
NM_001282653.1,NM_006819.2,
DescriptionHsp70/Hsp90-organizing proteinNY-REN-11 antigenepididymis secretory sperm binding protein Li 94nhsc70/Hsp90-organizing proteinrenal carcinoma antigen NY-REN-11stress-induced-phosphoprotein 1transformation-sensitive protein IEF SSP 3521
Modification date20141207
dbXrefs MIM : 605063
HGNC : HGNC
Ensembl : ENSG00000168439
HPRD : 05454
Vega : OTTHUMG00000167789
ProteinUniProt: P31948
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STIP1
BioGPS: 10963
PathwayNCI Pathway Interaction Database: STIP1
KEGG: STIP1
REACTOME: STIP1
Pathway Commons: STIP1
ContextiHOP: STIP1
ligand binding site mutation search in PubMed: STIP1
UCL Cancer Institute: STIP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for STIP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S76S76PCOAD1
N43R44SLUAD1
N233G232RLUAD1
S76S76LLUAD1
N43N43SSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STIP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S76S76L0.31112867
N43R44S-1.0520929
N43N43S-0.26271193
S76S76P-0.15288398
N233G232R-0.10313795
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STIP1 from PDB

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Differential gene expression and gene-gene network for STIP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STIP1 and the right PPI network was created from samples without mutations in the LBS of STIP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STIP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0025202Melanoma1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STIP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STIP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ACE,MET,GLU,GLU,VAL,ASP)1elrAN233
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP)3eskAN233
IIIPeptide ligand (ACE,MET,GLU,GLU,VAL,PHE)3fwvAN233
IIIPeptide ligand (ACE,MET,GLU,GLU,VAL,PHE)3fwvBN233
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP)1elwAN43 S76
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP)1elwBN43 S76


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Conservation information for LBS of STIP1
Multiple alignments for P31948 in multiple species
LBSAA sequence# speciesSpecies
A267ITNQAAVYFEK2Homo sapiens, Bos taurus
A267LTNRAAVYLEM2Arabidopsis thaliana, Arabidopsis thaliana
A267ITNQAAVHFEK2Mus musculus, Rattus norvegicus
A267LNNRAAAEYEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A267LNNLAAAYFEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A267ITNRAAVHLEM1Arabidopsis thaliana
A267YNNKAAVYFEE1Caenorhabditis elegans
A46YSNRSAAYAKK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A46FSNRSAAHASL2Arabidopsis thaliana, Arabidopsis thaliana
A46YSNRSACYTSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A46YSNRSACYASE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A46YSNRSASYASL1Arabidopsis thaliana
A46-----------1Caenorhabditis elegans
A49RSAAYAKKGDY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A49RSACYTSLKKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A49RSACYASEKDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A49RSASYASLHRY1Arabidopsis thaliana
A49RSAAHASLHQY1Arabidopsis thaliana
A49RSAAHASLNHY1Arabidopsis thaliana
A49-----------1Caenorhabditis elegans
A80YSRKAAALEFL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A80YSRLGAAHLGL2Arabidopsis thaliana, Arabidopsis thaliana
A80YNRLGAAHLGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A80WSRKGAALHGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A80YSRLGAAFIGL1Arabidopsis thaliana
A80-----------1Caenorhabditis elegans
E271AAVHFEKGDYN2Mus musculus, Rattus norvegicus
E271AAVYFEKGDYN1Homo sapiens
E271AAAEYEKGEYE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E271AAAYFEADQLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E271AAVYLEMGKYE1Arabidopsis thaliana
E271AAVYLEMGKYN1Arabidopsis thaliana
E271AAVHLEMGKYD1Arabidopsis thaliana
E271AAVYFEEKKFA1Caenorhabditis elegans
E271AAVYFEKGDYG1Bos taurus
E83KAAALEFLNRF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E83LGAAHLGLNQF2Arabidopsis thaliana, Arabidopsis thaliana
E83LGAAHLGLGDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E83KGAALHGLGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E83LGAAFIGLSKF1Arabidopsis thaliana
E83-----------1Caenorhabditis elegans
F241YKKKDFDTALK2Homo sapiens, Bos taurus
F241YKKKDFETAIQ2Arabidopsis thaliana, Arabidopsis thaliana
F241YKKKDFDKALK2Mus musculus, Rattus norvegicus
F241YKARQFDEAIE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F241YKKRNFPVAIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F241YKKKDFGRAVE1Arabidopsis thaliana
F241YKQKDFEKAHV1Caenorhabditis elegans
F270QAAVYFEKGDY2Homo sapiens, Bos taurus
F270RAAVYLEMGKY2Arabidopsis thaliana, Arabidopsis thaliana
F270QAAVHFEKGDY2Mus musculus, Rattus norvegicus
F270RAAAEYEKGEY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F270LAAAYFEADQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F270RAAVHLEMGKY1Arabidopsis thaliana
F270KAAVYFEEKKF1Caenorhabditis elegans
F84AAALEFLNRFE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F84GAAHLGLGDLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F84GAALHGLGDLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F84GAAFIGLSKFD1Arabidopsis thaliana
F84GAAHLGLNQFE1Arabidopsis thaliana
F84GAAHLGLNQFD1Arabidopsis thaliana
F84-----------1Caenorhabditis elegans
K229QALKEKELGND3Homo sapiens, Mus musculus, Rattus norvegicus
K229EADKEKAEGNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K229KADQEKQIGNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K229KALKEKGEGNV1Arabidopsis thaliana
K229KAKKEKELGNA1Arabidopsis thaliana
K229KAQKEKELGNA1Arabidopsis thaliana
K229AAIAEKDLGNA1Caenorhabditis elegans
K229QALREKELGNE1Bos taurus
K239AAYKKKDFETA2Arabidopsis thaliana, Arabidopsis thaliana
K239DAYKKKDFDKA2Mus musculus, Rattus norvegicus
K239DAYKKKDFDTA1Homo sapiens
K239KFYKARQFDEA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K239ENYKKRNFPVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K239VAYKKKDFGRA1Arabidopsis thaliana
K239AAYKQKDFEKA1Caenorhabditis elegans
K239EAYKKKDFDTA1Bos taurus
K301YRQIAKAYARI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K301YKVISKSFARI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K301FKLIAKALGRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K301FKMIARALTRK1Arabidopsis thaliana
K301YKMVARALTRK1Arabidopsis thaliana
K301YKMVAKALTRK1Arabidopsis thaliana
K301YKLIAKAMSRA1Caenorhabditis elegans
K50SAAYAKKGDYQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K50SACYTSLKKFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K50SACYASEKDYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K50SASYASLHRYE1Arabidopsis thaliana
K50SAAHASLHQYA1Arabidopsis thaliana
K50SAAHASLNHYD1Arabidopsis thaliana
K50-----------1Caenorhabditis elegans
K73KPDWGKGYSRK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K73NPSWSKGYNRL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K73KPDWAKGWSRK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K73KPDWSKGYSRL1Arabidopsis thaliana
K73KPYWPKGYSRL1Arabidopsis thaliana
K73KPDWGKGYSRL1Arabidopsis thaliana
K73-----------1Caenorhabditis elegans
K8QVNELKEKGNK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K8TADEYKQQGNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K8MAEELKAKGNA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K8MAEEAKSKGNA1Arabidopsis thaliana
K8MAEEAKAKGNA1Arabidopsis thaliana
K8MADEAKAKGNA1Arabidopsis thaliana
K8-----------1Caenorhabditis elegans
L15KGNKALSAGNI3Bos taurus, Mus musculus, Rattus norvegicus
L15KGNAAFSSGDF2Arabidopsis thaliana, Arabidopsis thaliana
L15KGNKALSVGNI1Homo sapiens
L15QGNAAFTAKDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L15KGNAAFSKKDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L15KGNAAFSSGDY1Arabidopsis thaliana
L15-----------1Caenorhabditis elegans
N12LKEKGNKALSA3Bos taurus, Mus musculus, Rattus norvegicus
N12AKAKGNAAFSS2Arabidopsis thaliana, Arabidopsis thaliana
N12LKEKGNKALSV1Homo sapiens
N12YKQQGNAAFTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N12LKAKGNAAFSK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N12AKSKGNAAFSS1Arabidopsis thaliana
N12-----------1Caenorhabditis elegans
N233EKELGNDAYKK3Homo sapiens, Mus musculus, Rattus norvegicus
N233EKELGNAAYKK2Arabidopsis thaliana, Arabidopsis thaliana
N233EKAEGNKFYKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N233EKQIGNENYKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N233EKGEGNVAYKK1Arabidopsis thaliana
N233EKDLGNAAYKQ1Caenorhabditis elegans
N233EKELGNEAYKK1Bos taurus
N264MTYITNQAAVY2Homo sapiens, Bos taurus
N264ISYLTNRAAVY2Arabidopsis thaliana, Arabidopsis thaliana
N264MTYITNQAAVH2Mus musculus, Rattus norvegicus
N264ITYLNNRAAAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N264ITYLNNLAAAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N264ISYITNRAAVH1Arabidopsis thaliana
N264ITFYNNKAAVY1Caenorhabditis elegans
N308YARIGNSYFK-4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N308FARIGNAYHK-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N308LGRLGTTYQK-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N308LTRKGSALVKM1Arabidopsis thaliana
N308LTRKGTALTKM1Arabidopsis thaliana
N308LTRKGTALGKM1Arabidopsis thaliana
N308MSRAGNAFQK-1Caenorhabditis elegans
N43HVLYSNRSAAY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N43HVLFSNRSAAH2Arabidopsis thaliana, Arabidopsis thaliana
N43HVLYSNRSACY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N43HILYSNRSACY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N43HILYSNRSASY1Arabidopsis thaliana
N43-----------1Caenorhabditis elegans
Q107EANNPQLKEGL2Homo sapiens, Bos taurus
Q107EANNLQLKEGL2Mus musculus, Rattus norvegicus
Q107DASNKAAKEGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q107DANNAQLLNGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q107DPSNEMLKSGL1Arabidopsis thaliana
Q107DPTNEALKSGL1Arabidopsis thaliana
Q107DPSNEGLKSGL1Arabidopsis thaliana
Q107-----------1Caenorhabditis elegans
Q298REDYRQIAKAY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q298RADYKVISKSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q298RADFKLIAKAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q298RSDFKMIARAL1Arabidopsis thaliana
Q298RSDYKMVARAL1Arabidopsis thaliana
Q298RSDYKMVAKAL1Arabidopsis thaliana
Q298RADYKLIAKAM1Caenorhabditis elegans
R305AKAYARIGNSY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R305SKSFARIGNAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R305AKALGRLGTTY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R305ARALTRKGSAL1Arabidopsis thaliana
R305ARALTRKGTAL1Arabidopsis thaliana
R305AKALTRKGTAL1Arabidopsis thaliana
R305AKAMSRAGNAF1Caenorhabditis elegans
R77GKGYSRKAAAL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R77SKGYNRLGAAH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R77AKGWSRKGAAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R77SKGYSRLGAAF1Arabidopsis thaliana
R77PKGYSRLGAAH1Arabidopsis thaliana
R77GKGYSRLGAAH1Arabidopsis thaliana
R77-----------1Caenorhabditis elegans
S76WGKGYSRKAAA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S76WSKGYNRLGAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S76WAKGWSRKGAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S76WSKGYSRLGAA1Arabidopsis thaliana
S76WPKGYSRLGAA1Arabidopsis thaliana
S76WGKGYSRLGAA1Arabidopsis thaliana
S76-----------1Caenorhabditis elegans
T260DPTNMTYITNQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T260DDEDISYLTNR2Arabidopsis thaliana, Arabidopsis thaliana
T260H-KDITYLNNR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T260Y-KDITYLNNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T260DDEDISYITNR1Arabidopsis thaliana
T260DPSNITFYNNK1Caenorhabditis elegans
V39PQ-NHVLYSNR3Bos taurus, Mus musculus, Rattus norvegicus
V39PT-NHVLFSNR2Arabidopsis thaliana, Arabidopsis thaliana
V39PH-NHVLYSNR1Homo sapiens
V39ETPNHVLYSNR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V39ER-NHILYSNR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V39PT-NHILYSNR1Arabidopsis thaliana
V39-----------1Caenorhabditis elegans
W71DLKPDWGKGYS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W71KINPSWSKGYN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W71ELKPDWAKGWS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W71ELKPDWSKGYS1Arabidopsis thaliana
W71KLKPYWPKGYS1Arabidopsis thaliana
W71ELKPDWGKGYS1Arabidopsis thaliana
W71-----------1Caenorhabditis elegans
Y236LGNDAYKKKDF3Homo sapiens, Mus musculus, Rattus norvegicus
Y236LGNAAYKKKDF2Arabidopsis thaliana, Arabidopsis thaliana
Y236EGNKFYKARQF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y236IGNENYKKRNF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y236EGNVAYKKKDF1Arabidopsis thaliana
Y236LGNAAYKQKDF1Caenorhabditis elegans
Y236LGNEAYKKKDF1Bos taurus
Y248TALKHYDKAKE1Homo sapiens
Y248EAIEHYNKAWE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y248VAIEQYKKAWD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y248RAVEHYTKAME1Arabidopsis thaliana
Y248TAIQHYSTAIE1Arabidopsis thaliana
Y248TAIQHYSTAME1Arabidopsis thaliana
Y248KAHVHYDKAIE1Caenorhabditis elegans
Y248TALKHYDKAKD1Bos taurus
Y248KALKHYDRAKE1Mus musculus
Y248KALKHYDKAKE1Rattus norvegicus


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