mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NUDT21
Gene summary
Basic gene Info.Gene symbolNUDT21
Gene namenudix (nucleoside diphosphate linked moiety X)-type motif 21
SynonymsCFIM25|CPSF5
CytomapUCSC genome browser: 16q12.2
Type of geneprotein-coding
RefGenesNM_007006.2,
DescriptionCPSF 25 kDa subunitcleavage and polyadenylation specific factor 5, 25 kD subunitcleavage and polyadenylation specific factor 5, 25 kDacleavage and polyadenylation specificity factor 25 kDa subunitcleavage and polyadenylation specificity factor subunit
Modification date20141207
dbXrefs MIM : 604978
HGNC : HGNC
Ensembl : ENSG00000167005
HPRD : 05400
Vega : OTTHUMG00000133240
ProteinUniProt: O43809
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NUDT21
BioGPS: 11051
PathwayNCI Pathway Interaction Database: NUDT21
KEGG: NUDT21
REACTOME: NUDT21
Pathway Commons: NUDT21
ContextiHOP: NUDT21
ligand binding site mutation search in PubMed: NUDT21
UCL Cancer Institute: NUDT21
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006397mRNA processing8626397
GO:0051262protein tetramerization21295486


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Ligand binding site mutations for NUDT21

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F104F104CBRCA1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for NUDT21
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F104F104C-1.0237542
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NUDT21 from PDB

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Differential gene expression and gene-gene network for NUDT21
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NUDT21 and the right PPI network was created from samples without mutations in the LBS of NUDT21. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for NUDT21
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for NUDT21
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NUDT21 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3mdgAF104
NUCNucleic Acids3mdiAF104
NUCNucleic Acids3p6yAF104
NUCNucleic Acids3p6yBF104
NUCNucleic Acids3p6yEF104
NUCNucleic Acids3p6yFF104
NUCNucleic Acids3p6yIF104
NUCNucleic Acids3p6yMF104
NUCNucleic Acids3p6yNF104
NUCNucleic Acids3q2tAF104
NUCNucleic Acids3q2tBF104


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Conservation information for LBS of NUDT21
Multiple alignments for O43809 in multiple species
LBSAA sequence# speciesSpecies
A205ELYDNAPGYGP5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
A205ELYDNVQRYGP1Arabidopsis thaliana
E55KEPLYEKDSSV5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
E55KEPKLEKDTSV1Arabidopsis thaliana
F103QLGTTFFKLPG5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
F103QIGNTFCKLPG1Arabidopsis thaliana
F104LGTTFFKLPGG5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
F104IGNTFCKLPGG1Arabidopsis thaliana
G100LLLQLGTTFFK5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G100LLLQIGNTFCK1Arabidopsis thaliana
G207YDNAPGYGPII5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G207YDNVQRYGPVI1Arabidopsis thaliana
G209NAPGYGPIISS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G209NVQRYGPVIST1Arabidopsis thaliana
K172KPKEHKKLFLV5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
K172KPKECKRLYIV1Arabidopsis thaliana
K189LFAVPKNYKLV5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
K189YFAVPKNLKLL1Arabidopsis thaliana
K192VPKNYKLVAAP5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
K192VPKNLKLLAVP1Arabidopsis thaliana
L99VLLLQLGTTFF5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
L99ILLLQIGNTFC1Arabidopsis thaliana
N190FAVPKNYKLVA5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
N190FAVPKNLKLLA1Arabidopsis thaliana
P155RPNFEPPQYPY5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
P155RPNFETMMYPY1Arabidopsis thaliana
P206LYDNAPGYGPI5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
P206LYDNVQRYGPV1Arabidopsis thaliana
Q157NFEPPQYPYIP5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Q157NFETMMYPYCP1Arabidopsis thaliana
R150IGNWWRPNFEP5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
R150VATWWRPNFET1Arabidopsis thaliana
R63SSVAARFQRMR5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
R63TSVADRLARMK1Arabidopsis thaliana
S58LYEKDSSVAAR5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
S58KLEKDTSVADR1Arabidopsis thaliana
S59YEKDSSVAARF5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
S59LEKDTSVADRL1Arabidopsis thaliana
T101LLQLGTTFFKL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
T101LLQIGNTFCKL1Arabidopsis thaliana
T102LQLGTTFFKLP5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
T102LQIGNTFCKLP1Arabidopsis thaliana
V60EKDSSVAARFQ5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
V60EKDTSVADRLA1Arabidopsis thaliana
Y208DNAPGYGPIIS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Y208DNVQRYGPVIS1Arabidopsis thaliana
Y54TKEPLYEKDSS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Y54TKEPKLEKDTS1Arabidopsis thaliana


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