mutLBSgeneDB |
Gene summary for NUDT21 |
Gene summary |
Basic gene Info. | Gene symbol | NUDT21 |
Gene name | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | |
Synonyms | CFIM25|CPSF5 | |
Cytomap | UCSC genome browser: 16q12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_007006.2, | |
Description | CPSF 25 kDa subunitcleavage and polyadenylation specific factor 5, 25 kD subunitcleavage and polyadenylation specific factor 5, 25 kDacleavage and polyadenylation specificity factor 25 kDa subunitcleavage and polyadenylation specificity factor subunit | |
Modification date | 20141207 | |
dbXrefs | MIM : 604978 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167005 | ||
HPRD : 05400 | ||
Vega : OTTHUMG00000133240 | ||
Protein | UniProt: O43809 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NUDT21 | |
BioGPS: 11051 | ||
Pathway | NCI Pathway Interaction Database: NUDT21 | |
KEGG: NUDT21 | ||
REACTOME: NUDT21 | ||
Pathway Commons: NUDT21 | ||
Context | iHOP: NUDT21 | |
ligand binding site mutation search in PubMed: NUDT21 | ||
UCL Cancer Institute: NUDT21 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006397 | mRNA processing | 8626397 | GO:0051262 | protein tetramerization | 21295486 |
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Ligand binding site mutations for NUDT21 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | F104 | F104C | BRCA | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for NUDT21 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | F104 | F104C | -1.0237542 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for NUDT21 from PDB |
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Differential gene expression and gene-gene network for NUDT21 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for NUDT21 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for NUDT21 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of NUDT21 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 3mdg | A | F104 | NUC | Nucleic Acids | 3mdi | A | F104 | NUC | Nucleic Acids | 3p6y | A | F104 | NUC | Nucleic Acids | 3p6y | B | F104 | NUC | Nucleic Acids | 3p6y | E | F104 | NUC | Nucleic Acids | 3p6y | F | F104 | NUC | Nucleic Acids | 3p6y | I | F104 | NUC | Nucleic Acids | 3p6y | M | F104 | NUC | Nucleic Acids | 3p6y | N | F104 | NUC | Nucleic Acids | 3q2t | A | F104 | NUC | Nucleic Acids | 3q2t | B | F104 |
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Conservation information for LBS of NUDT21 |
Multiple alignments for O43809 in multiple species |
LBS | AA sequence | # species | Species | A205 | ELYDNAPGYGP | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | A205 | ELYDNVQRYGP | 1 | Arabidopsis thaliana | E55 | KEPLYEKDSSV | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | E55 | KEPKLEKDTSV | 1 | Arabidopsis thaliana | F103 | QLGTTFFKLPG | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | F103 | QIGNTFCKLPG | 1 | Arabidopsis thaliana | F104 | LGTTFFKLPGG | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | F104 | IGNTFCKLPGG | 1 | Arabidopsis thaliana | G100 | LLLQLGTTFFK | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | G100 | LLLQIGNTFCK | 1 | Arabidopsis thaliana | G207 | YDNAPGYGPII | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | G207 | YDNVQRYGPVI | 1 | Arabidopsis thaliana | G209 | NAPGYGPIISS | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | G209 | NVQRYGPVIST | 1 | Arabidopsis thaliana | K172 | KPKEHKKLFLV | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | K172 | KPKECKRLYIV | 1 | Arabidopsis thaliana | K189 | LFAVPKNYKLV | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | K189 | YFAVPKNLKLL | 1 | Arabidopsis thaliana | K192 | VPKNYKLVAAP | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | K192 | VPKNLKLLAVP | 1 | Arabidopsis thaliana | L99 | VLLLQLGTTFF | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | L99 | ILLLQIGNTFC | 1 | Arabidopsis thaliana | N190 | FAVPKNYKLVA | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | N190 | FAVPKNLKLLA | 1 | Arabidopsis thaliana | P155 | RPNFEPPQYPY | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | P155 | RPNFETMMYPY | 1 | Arabidopsis thaliana | P206 | LYDNAPGYGPI | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | P206 | LYDNVQRYGPV | 1 | Arabidopsis thaliana | Q157 | NFEPPQYPYIP | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | Q157 | NFETMMYPYCP | 1 | Arabidopsis thaliana | R150 | IGNWWRPNFEP | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | R150 | VATWWRPNFET | 1 | Arabidopsis thaliana | R63 | SSVAARFQRMR | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | R63 | TSVADRLARMK | 1 | Arabidopsis thaliana | S58 | LYEKDSSVAAR | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | S58 | KLEKDTSVADR | 1 | Arabidopsis thaliana | S59 | YEKDSSVAARF | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | S59 | LEKDTSVADRL | 1 | Arabidopsis thaliana | T101 | LLQLGTTFFKL | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | T101 | LLQIGNTFCKL | 1 | Arabidopsis thaliana | T102 | LQLGTTFFKLP | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | T102 | LQIGNTFCKLP | 1 | Arabidopsis thaliana | V60 | EKDSSVAARFQ | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | V60 | EKDTSVADRLA | 1 | Arabidopsis thaliana | Y208 | DNAPGYGPIIS | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | Y208 | DNVQRYGPVIS | 1 | Arabidopsis thaliana | Y54 | TKEPLYEKDSS | 5 | Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus | Y54 | TKEPKLEKDTS | 1 | Arabidopsis thaliana |
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