|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for FICD |
 Gene summary |
| Basic gene Info. | Gene symbol | FICD |
| Gene name | FIC domain containing | |
| Synonyms | HIP13|HYPE|UNQ3041 | |
| Cytomap | UCSC genome browser: 12q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007076.2, | |
| Description | AMPylator FICDFIC domain-containing proteinHIP-13Huntingtin interacting protein Eadenosine monophosphate-protein transferase FICDfic S-phase protein cell division homologhuntingtin interacting protein 13huntingtin interactor protein Ehuntingtin ye | |
| Modification date | 20141215 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 13723 | ||
| Protein | UniProt: Q9BVA6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FICD | |
| BioGPS: 11153 | ||
| Pathway | NCI Pathway Interaction Database: FICD | |
| KEGG: FICD | ||
| REACTOME: FICD | ||
| Pathway Commons: FICD | ||
| Context | iHOP: FICD | |
| ligand binding site mutation search in PubMed: FICD | ||
| UCL Cancer Institute: FICD | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0018117 | protein adenylylation | 22266942 |
| Top |
| Ligand binding site mutations for FICD |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R374 | L375V | COAD | 1 | N407 | N407I | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for FICD |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R374 | L375V | -1.3450278 | N407 | N407I | -0.13716417 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FICD from PDB |
| Top |
| Differential gene expression and gene-gene network for FICD |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for FICD |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for FICD |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of FICD go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 4u0s | B | N407 | ATP | ATP | 4u07 | A | R374 N407 | ATP | ATP | 4u07 | B | R374 N407 | ADP | ADP | 4u0s | A | R374 N407 | ADP | ADP | 4u0u | A | R374 N407 | ADP | ADP | 4u0u | B | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | B | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | C | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | D | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | E | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | F | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | G | R374 N407 | APC | ALPHA,BETA-METHYLENE ATP | 4u0z | H | R374 N407 |
| Top |
| Conservation information for LBS of FICD |
| Multiple alignments for Q9BVA6 in multiple species |
| LBS | AA sequence | # species | Species | D367 | IHPFIDGNGRT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D367 | IHPFVDGNGRT | 2 | Drosophila melanogaster, Xenopus tropicalis | D367 | VHPFTDGNGRT | 1 | Caenorhabditis elegans | D367 | VHPFVDGNGRT | 1 | Danio rerio | E234 | HTVAIEGNTLT | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | E234 | HTVAIEGNTLS | 2 | Caenorhabditis elegans, Xenopus tropicalis | E234 | HSVGIEGNTMT | 1 | Drosophila melanogaster | G368 | HPFIDGNGRTS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G368 | HPFVDGNGRTS | 3 | Drosophila melanogaster, Danio rerio, Xenopus tropicalis | G368 | HPFTDGNGRTA | 1 | Caenorhabditis elegans | G370 | FIDGNGRTSRL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G370 | FVDGNGRTSRL | 3 | Drosophila melanogaster, Danio rerio, Xenopus tropicalis | G370 | FTDGNGRTARL | 1 | Caenorhabditis elegans | H319 | VLVGHHIPPHP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H319 | VFVGHHIPPHP | 2 | Danio rerio, Xenopus tropicalis | H319 | VYVGRFTPVSP | 1 | Caenorhabditis elegans | H319 | VYVGGHIPPGP | 1 | Drosophila melanogaster | H363 | KLVYIHPFIDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H363 | KLVLVHPFTDG | 1 | Caenorhabditis elegans | H363 | KLVHIHPFVDG | 1 | Drosophila melanogaster | H363 | KLVYVHPFVDG | 1 | Danio rerio | H363 | KLVYIHPFVDG | 1 | Xenopus tropicalis | I233 | YHTVAIEGNTL | 6 | Homo sapiens, Caenorhabditis elegans, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus | I233 | YHSVGIEGNTM | 1 | Drosophila melanogaster | L403 | EYYHVLEVANE | 2 | Mus musculus, Rattus norvegicus | L403 | DYYHVLEAANE | 1 | Homo sapiens | L403 | EYYASLHVANL | 1 | Caenorhabditis elegans | L403 | KYYHFLKLANE | 1 | Drosophila melanogaster | L403 | EYYAALDTANE | 1 | Danio rerio | L403 | EYYHVLEIANE | 1 | Xenopus tropicalis | N369 | PFIDGNGRTSR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N369 | PFVDGNGRTSR | 3 | Drosophila melanogaster, Danio rerio, Xenopus tropicalis | N369 | PFTDGNGRTAR | 1 | Caenorhabditis elegans | N407 | VLEVANEGDVR | 2 | Mus musculus, Rattus norvegicus | N407 | VLEAANEGDVR | 1 | Homo sapiens | N407 | SLHVANLGDLR | 1 | Caenorhabditis elegans | N407 | FLKLANEGDIR | 1 | Drosophila melanogaster | N407 | ALDTANEGDVR | 1 | Danio rerio | N407 | VLEIANEGDVR | 1 | Xenopus tropicalis | R371 | IDGNGRTSRLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R371 | VDGNGRTSRLL | 3 | Drosophila melanogaster, Danio rerio, Xenopus tropicalis | R371 | TDGNGRTARLL | 1 | Caenorhabditis elegans | R374 | NGRTSRLLMNL | 5 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus | R374 | NGRTARLLLNL | 1 | Caenorhabditis elegans | R374 | NGRTSRLLMNT | 1 | Drosophila melanogaster | V316 | RTQVLVGHHIP | 2 | Mus musculus, Rattus norvegicus | V316 | TTQVLVGHHIP | 1 | Homo sapiens | V316 | TTQVYVGRFTP | 1 | Caenorhabditis elegans | V316 | RNQVYVGGHIP | 1 | Drosophila melanogaster | V316 | VNQVFVGHHIP | 1 | Danio rerio | V316 | RNQVFVGHHIP | 1 | Xenopus tropicalis | V360 | AHYKLVYIHPF | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | V360 | AHYKLVLVHPF | 1 | Caenorhabditis elegans | V360 | AHYKLVHIHPF | 1 | Drosophila melanogaster | V360 | AHYKLVYVHPF | 1 | Danio rerio | Y399 | EQRSEYYHVLE | 3 | Xenopus tropicalis, Mus musculus, Rattus norvegicus | Y399 | EQRSDYYHVLE | 1 | Homo sapiens | Y399 | ETRAEYYASLH | 1 | Caenorhabditis elegans | Y399 | QQRSKYYHFLK | 1 | Drosophila melanogaster | Y399 | EQRAEYYAALD | 1 | Danio rerio | Y400 | QRSEYYHVLEV | 2 | Mus musculus, Rattus norvegicus | Y400 | QRSDYYHVLEA | 1 | Homo sapiens | Y400 | TRAEYYASLHV | 1 | Caenorhabditis elegans | Y400 | QRSKYYHFLKL | 1 | Drosophila melanogaster | Y400 | QRAEYYAALDT | 1 | Danio rerio | Y400 | QRSEYYHVLEI | 1 | Xenopus tropicalis |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |