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mutLBSgeneDB |
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| Gene summary for SAT2 |
 Gene summary |
| Basic gene Info. | Gene symbol | SAT2 |
| Gene name | spermidine/spermine N1-acetyltransferase family member 2 | |
| Synonyms | SSAT2 | |
| Cytomap | UCSC genome browser: 17p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_133491.3, | |
| Description | diamine N-acetyltransferase 2diamine acetyltransferase 2polyamine N-acetyltransferase 2spermidine/spermine N(1)-acetyltransferase 2spermidine/spermine N1-acetyltransferase 2thialysine N-epsilon-acetyltransferase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611463 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000141504 | ||
| HPRD : 15296 | ||
| Vega : OTTHUMG00000108152 | ||
| Protein | UniProt: Q96F10 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SAT2 | |
| BioGPS: 112483 | ||
| Pathway | NCI Pathway Interaction Database: SAT2 | |
| KEGG: SAT2 | ||
| REACTOME: SAT2 | ||
| Pathway Commons: SAT2 | ||
| Context | iHOP: SAT2 | |
| ligand binding site mutation search in PubMed: SAT2 | ||
| UCL Cancer Institute: SAT2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0032918 | spermidine acetylation | 12803540 | GO:0032919 | spermine acetylation | 12803540 | GO:0032920 | putrescine acetylation | 12803540 | GO:0046204 | nor-spermidine metabolic process | 12803540 |
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| Ligand binding site mutations for SAT2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S107 | S107F | COAD | 1 | V129 | V129I | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SAT2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V129 | V129I | -1.0869941 | S107 | S107F | -0.96162432 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SAT2 from PDB |
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| Differential gene expression and gene-gene network for SAT2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SAT2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SAT2 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SAT2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ACO | ACETYL COENZYME *A | 2q4v | A | S107 | ACO | ACETYL COENZYME *A | 2bei | A | S107 V129 |
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| Conservation information for LBS of SAT2 |
| Multiple alignments for Q96F10 in multiple species |
| LBS | AA sequence | # species | Species | A128 | SQFRLAVLDWN | 2 | Homo sapiens, Mus musculus | A128 | RRLDWVVLDWN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A128 | SQLRLAVLDWN | 1 | Bos taurus | A136 | DWNQRAMDLYK | 1 | Homo sapiens | A136 | DWNQRAIEVYE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A136 | DWNKKAVNLYK | 1 | Mus musculus | A136 | DWNKRAMDLYK | 1 | Bos taurus | D93 | TIYLEDIYVMP | 1 | Homo sapiens | D93 | GIYLEDLYVRP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D93 | NVYLEDIYVMP | 1 | Mus musculus | D93 | NIYLEDIYVKP | 1 | Bos taurus | E92 | -TIYLEDIYVM | 1 | Homo sapiens | E92 | VGIYLEDLYVR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E92 | -NVYLEDIYVM | 1 | Mus musculus | E92 | -NIYLEDIYVK | 1 | Bos taurus | G102 | MPEYRGQGIGS | 1 | Homo sapiens | G102 | RPQFRGKGYGS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G102 | MPQYRGQGIGT | 1 | Mus musculus | G102 | KPEYRGQGIGS | 1 | Bos taurus | G104 | EYRGQGIGSKI | 2 | Homo sapiens, Bos taurus | G104 | QFRGKGYGSYL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G104 | QYRGQGIGTKI | 1 | Mus musculus | G106 | RGQGIGSKIIK | 2 | Homo sapiens, Bos taurus | G106 | RGKGYGSYLLS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G106 | RGQGIGTKIIK | 1 | Mus musculus | I105 | YRGQGIGSKII | 2 | Homo sapiens, Bos taurus | I105 | FRGKGYGSYLL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I105 | YRGQGIGTKII | 1 | Mus musculus | I94 | IYLEDIYVMPE | 1 | Homo sapiens | I94 | IYLEDLYVRPQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I94 | VYLEDIYVMPQ | 1 | Mus musculus | I94 | IYLEDIYVKPE | 1 | Bos taurus | L127 | CSQFRLAVLDW | 2 | Homo sapiens, Mus musculus | L127 | GRRLDWVVLDW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L127 | CSQLRLAVLDW | 1 | Bos taurus | L139 | QRAMDLYKALG | 1 | Homo sapiens | L139 | QRAIEVYEKAG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L139 | KKAVNLYKFLG | 1 | Mus musculus | L139 | KRAMDLYKALG | 1 | Bos taurus | L24 | RLIRELAEFEK | 1 | Homo sapiens | L24 | QFIKELAEFEK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L24 | RMIRELAEFEK | 1 | Mus musculus | L24 | RLIRELAEYEK | 1 | Bos taurus | L91 | R-TIYLEDIYV | 1 | Homo sapiens | L91 | RVGIYLEDLYV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L91 | R-NVYLEDIYV | 1 | Mus musculus | L91 | R-NIYLEDIYV | 1 | Bos taurus | N133 | AVLDWNQRAMD | 1 | Homo sapiens | N133 | VVLDWNQRAIE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N133 | AVLDWNKKAVN | 1 | Mus musculus | N133 | AVLDWNKRAMD | 1 | Bos taurus | Q103 | PEYRGQGIGSK | 2 | Homo sapiens, Bos taurus | Q103 | PQFRGKGYGSY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q103 | PQYRGQGIGTK | 1 | Mus musculus | R101 | VMPEYRGQGIG | 1 | Homo sapiens | R101 | VRPQFRGKGYG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R101 | VMPQYRGQGIG | 1 | Mus musculus | R101 | VKPEYRGQGIG | 1 | Bos taurus | R135 | LDWNQRAMDLY | 1 | Homo sapiens | R135 | LDWNQRAIEVY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R135 | LDWNKKAVNLY | 1 | Mus musculus | R135 | LDWNKRAMDLY | 1 | Bos taurus | S107 | GQGIGSKIIKK | 2 | Homo sapiens, Bos taurus | S107 | GKGYGSYLLSY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S107 | GQGIGTKIIKK | 1 | Mus musculus | V129 | QFRLAVLDWNQ | 1 | Homo sapiens | V129 | RLDWVVLDWNQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V129 | QFRLAVLDWNK | 1 | Mus musculus | V129 | QLRLAVLDWNK | 1 | Bos taurus | V96 | LEDIYVMPEYR | 1 | Homo sapiens | V96 | LEDLYVRPQFR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V96 | LEDIYVMPQYR | 1 | Mus musculus | V96 | LEDIYVKPEYR | 1 | Bos taurus | Y140 | RAMDLYKALGA | 2 | Homo sapiens, Bos taurus | Y140 | RAIEVYEKAGA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y140 | KAVNLYKFLGA | 1 | Mus musculus | Y95 | YLEDIYVMPEY | 1 | Homo sapiens | Y95 | YLEDLYVRPQF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y95 | YLEDIYVMPQY | 1 | Mus musculus | Y95 | YLEDIYVKPEY | 1 | Bos taurus |
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