mutLBSgeneDB |
Gene summary for IL17F |
Gene summary |
Basic gene Info. | Gene symbol | IL17F |
Gene name | interleukin 17F | |
Synonyms | CANDF6|IL-17F|ML-1|ML1 | |
Cytomap | UCSC genome browser: 6p12 | |
Type of gene | protein-coding | |
RefGenes | NM_052872.3, | |
Description | cytokine ML-1interleukin-17F | |
Modification date | 20141207 | |
dbXrefs | MIM : 606496 | |
HGNC : HGNC | ||
Ensembl : ENSG00000112116 | ||
HPRD : 16224 | ||
Vega : OTTHUMG00000014845 | ||
Protein | UniProt: Q96PD4 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL17F | |
BioGPS: 112744 | ||
Pathway | NCI Pathway Interaction Database: IL17F | |
KEGG: IL17F | ||
REACTOME: IL17F | ||
Pathway Commons: IL17F | ||
Context | iHOP: IL17F | |
ligand binding site mutation search in PubMed: IL17F | ||
UCL Cancer Institute: IL17F | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006029 | proteoglycan metabolic process | 11574464 | GO:0016525 | negative regulation of angiogenesis | 11591732 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 11591732 | GO:0042089 | cytokine biosynthetic process | 11591732 | GO:0042109 | lymphotoxin A biosynthetic process | 11591732 | GO:0045076 | regulation of interleukin-2 biosynthetic process | 11591732 | GO:0045408 | regulation of interleukin-6 biosynthetic process | 11574464 | GO:0045414 | regulation of interleukin-8 biosynthetic process | 11574464 | GO:0045423 | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | 11574464 | GO:0051216 | cartilage development | 11574464 |
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Ligand binding site mutations for IL17F |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | N73 | N73S | COAD | 1 | N73 | R72C | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for IL17F |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N73 | R72C | -0.69615083 | N73 | N73S | -0.60493319 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for IL17F from PDB |
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Differential gene expression and gene-gene network for IL17F |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for IL17F |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C3151405 | CANDIDIASIS, FAMILIAL, 6 | 1 | GeneticVariation |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for IL17F |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of IL17F go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of IL17F |
Multiple alignments for Q96PD4 in multiple species |
LBS | AA sequence | # species | Species |
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