mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IL17F
Gene summary
Basic gene Info.Gene symbolIL17F
Gene nameinterleukin 17F
SynonymsCANDF6|IL-17F|ML-1|ML1
CytomapUCSC genome browser: 6p12
Type of geneprotein-coding
RefGenesNM_052872.3,
Descriptioncytokine ML-1interleukin-17F
Modification date20141207
dbXrefs MIM : 606496
HGNC : HGNC
Ensembl : ENSG00000112116
HPRD : 16224
Vega : OTTHUMG00000014845
ProteinUniProt: Q96PD4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL17F
BioGPS: 112744
PathwayNCI Pathway Interaction Database: IL17F
KEGG: IL17F
REACTOME: IL17F
Pathway Commons: IL17F
ContextiHOP: IL17F
ligand binding site mutation search in PubMed: IL17F
UCL Cancer Institute: IL17F
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006029proteoglycan metabolic process11574464
GO:0016525negative regulation of angiogenesis11591732
GO:0017015regulation of transforming growth factor beta receptor signaling pathway11591732
GO:0042089cytokine biosynthetic process11591732
GO:0042109lymphotoxin A biosynthetic process11591732
GO:0045076regulation of interleukin-2 biosynthetic process11591732
GO:0045408regulation of interleukin-6 biosynthetic process11574464
GO:0045414regulation of interleukin-8 biosynthetic process11574464
GO:0045423regulation of granulocyte macrophage colony-stimulating factor biosynthetic process11574464
GO:0051216cartilage development11574464


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Ligand binding site mutations for IL17F
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
N73N73SCOAD1
N73R72CLUSC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for IL17F
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N73R72C-0.69615083
N73N73S-0.60493319
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IL17F from PDB

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Differential gene expression and gene-gene network for IL17F
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IL17F and the right PPI network was created from samples without mutations in the LBS of IL17F. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for IL17F
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C3151405CANDIDIASIS, FAMILIAL, 61GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for IL17F
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IL17F go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of IL17F
Multiple alignments for Q96PD4 in multiple species
LBSAA sequence# speciesSpecies


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