mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HENMT1
Gene summary
Basic gene Info.Gene symbolHENMT1
Gene nameHEN1 methyltransferase homolog 1 (Arabidopsis)
CytomapUCSC genome browser: 1p13.3
Type of geneprotein-coding
Descriptionsmall RNA 2'-O-methyltransferase
Modification date20141207
dbXrefs MIM : 612178
Ensembl : ENSG00000162639
HPRD : 08086
Vega : OTTHUMG00000011123
ProteinUniProt: Q5T8I9
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HENMT1
BioGPS: 113802
PathwayNCI Pathway Interaction Database: HENMT1
Pathway Commons: HENMT1
ContextiHOP: HENMT1
ligand binding site mutation search in PubMed: HENMT1
UCL Cancer Institute: HENMT1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for HENMT1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for HENMT1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HENMT1 from PDB

Differential gene expression and gene-gene network for HENMT1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HENMT1 and the right PPI network was created from samples without mutations in the LBS of HENMT1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for HENMT1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for HENMT1
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HENMT1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of HENMT1
Multiple alignments for Q5T8I9 in multiple species
LBSAA sequence# speciesSpecies
D78LLVGVDINEEK2Mus musculus, Rattus norvegicus
D78LLVGVDINEDK1Homo sapiens
D78HIGLVDIDKSL1Drosophila melanogaster
D78LLVGVDINSVV1Danio rerio
D78VLVGLDIDEDV1Xenopus tropicalis
D78VLAGLDICETV1Gallus gallus
E132LITCIELIEHL4Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus tropicalis
E132AVIAIELIEHV1Drosophila melanogaster
E132LVTCVELIEHL1Danio rerio
E132LVTCIELIEHL1Gallus gallus
G113VTLYHGSVVER2Mus musculus, Rattus norvegicus
G113ITLYHGSVVER1Homo sapiens
G113VQILQGNVADS1Drosophila melanogaster
G113IELYQGSVMER1Danio rerio
G113INLYQGSVTQK1Xenopus tropicalis
G113VTLHQGSVAHK1Gallus gallus
G55KVADLGCGDTS1Homo sapiens
G55KVVEFGCAEMR1Drosophila melanogaster
G55KVIDFGCAECC1Danio rerio
G55KVADLGCGDAK1Mus musculus
G55KVADLGCGDTK1Rattus norvegicus
G55KVADLGCSTCS1Xenopus tropicalis
G55KVADLGCADCT1Gallus gallus
G57ADLGCGDTSLL1Homo sapiens
G57VEFGCAEMRFF1Drosophila melanogaster
G57IDFGCAECCLL1Danio rerio
G57ADLGCGDAKLL1Mus musculus
G57ADLGCGDTKLL1Rattus norvegicus
G57ADLGCSTCSLL1Xenopus tropicalis
G57ADLGCADCTLL1Gallus gallus
H136IELIEHLDSDD2Mus musculus, Rattus norvegicus
H136IELIEHLDSGD1Homo sapiens
H136IELIEHVYDDV1Drosophila melanogaster
H136VELIEHLELEE1Danio rerio
H136IELIEHLEAEE1Xenopus tropicalis
H136IELIEHLQESE1Gallus gallus
I131DLITCIELIEH4Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus tropicalis
I131DAVIAIELIEH1Drosophila melanogaster
I131DLVTCVELIEH1Danio rerio
I131DLVTCIELIEH1Gallus gallus
I79LVGVDINEEKL2Mus musculus, Rattus norvegicus
I79LVGVDINEDKL1Homo sapiens
I79IGLVDIDKSLL1Drosophila melanogaster
I79LVGVDINSVVL1Danio rerio
I79LVGLDIDEDVL1Xenopus tropicalis
I79LAGLDICETVM1Gallus gallus
K83DINEEKLHSNG2Mus musculus, Rattus norvegicus
K83DINEDKLRWRG1Homo sapiens
K83DIDKSLLMRNL1Drosophila melanogaster
K83DINSVVLLKRM1Danio rerio
K83DIDEDVLSRKK1Xenopus tropicalis
K83DICETVMKEKM1Gallus gallus
L133ITCIELIEHLD3Homo sapiens, Mus musculus, Rattus norvegicus
L133VIAIELIEHVY1Drosophila melanogaster
L133VTCVELIEHLE1Danio rerio
L133ITCIELIEHLE1Xenopus tropicalis
L133VTCIELIEHLQ1Gallus gallus
L137ELIEHLDSDDL2Mus musculus, Rattus norvegicus
L137ELIEHLDSGDL1Homo sapiens
L137ELIEHVYDDVL1Drosophila melanogaster
L137ELIEHLELEEV1Danio rerio
L137ELIEHLEAEEL1Xenopus tropicalis
L137ELIEHLQESEL1Gallus gallus
S114TLYHGSVVERD3Homo sapiens, Mus musculus, Rattus norvegicus
S114QILQGNVADSS1Drosophila melanogaster
S114ELYQGSVMERE1Danio rerio
S114NLYQGSVTQKD1Xenopus tropicalis
S114TLHQGSVAHKD1Gallus gallus
V115LYHGSVVERDS3Homo sapiens, Mus musculus, Rattus norvegicus
V115ILQGNVADSSE1Drosophila melanogaster
V115LYQGSVMEREP1Danio rerio
V115LYQGSVTQKDP1Xenopus tropicalis
V115LHQGSVAHKDP1Gallus gallus
Y36LYKQRY----Q2Mus musculus, Rattus norvegicus
Y36LYRQRY----Q1Homo sapiens
Y36VYEQRYCATIQ1Drosophila melanogaster
Y36LYMQRY----Q1Danio rerio
Y36LYQQRY----Q1Xenopus tropicalis
Y36LYKQRY----E1Gallus gallus

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