mutLBSgeneDB |
Gene summary for CYGB |
Gene summary |
Basic gene Info. | Gene symbol | CYGB |
Gene name | cytoglobin | |
Synonyms | HGB|STAP | |
Cytomap | UCSC genome browser: 17q25 | |
Type of gene | protein-coding | |
RefGenes | NM_134268.4, | |
Description | histoglobinstellate cell activation-associated protein | |
Modification date | 20141222 | |
dbXrefs | MIM : 608759 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161544 | ||
HPRD : 06479 | ||
Vega : OTTHUMG00000180289 | ||
Protein | UniProt: Q8WWM9 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYGB | |
BioGPS: 114757 | ||
Pathway | NCI Pathway Interaction Database: CYGB | |
KEGG: CYGB | ||
REACTOME: CYGB | ||
Pathway Commons: CYGB | ||
Context | iHOP: CYGB | |
ligand binding site mutation search in PubMed: CYGB | ||
UCL Cancer Institute: CYGB | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CYGB |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H81,Q77 | R79W | COAD | 1 | F49 | R48M | COAD | 1 | Q77 | S75R | OV | 1 | H113 | A114T | STAD | 1 | R155 | R155H | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CYGB |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | F49 | R48M | -0.90302545 | R155 | R155H | -0.65941595 | H81 | R79W | -0.65055161 | Q77 | R79W | -0.65055161 | H113 | A114T | -0.46021976 | Q77 | S75R | -0.12204447 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CYGB from PDB |
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Differential gene expression and gene-gene network for CYGB |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CYGB |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0751870 | Heredodegenerative Disorders, Nervous System | 1 | Biomarker |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CYGB |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CYGB go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | HEM | HEME B | 4b3w | A | F49 H113 | HEM | HEME B | 1urv | B | F49 H81 H113 | HEM | HEME B | 1ut0 | B | F49 H81 H113 | HEM | HEME B | 1umo | B | F49 Q77 H81 H113 | HEM | HEME B | 1urv | A | F49 Q77 H81 H113 | HEM | HEME B | 1ut0 | A | F49 Q77 H81 H113 | HEM | HEME B | 2dc3 | A | F49 Q77 H81 H113 | HEM | HEME B | 2dc3 | B | F49 Q77 H81 H113 | HEM | HEME B | 4b3w | B | H113 | HEM | HEME B | 3ag0 | A | H81 H113 | HEM | HEME B | 1umo | A | Q77 H81 H113 | HEM | HEME B | 1ury | A | Q77 H81 H113 | HEM | HEME B | 1ury | B | Q77 H81 H113 | HEM | HEME B | 1ux9 | A | Q77 H81 H113 | HEM | HEME B | 1ux9 | B | Q77 H81 H113 | HEM | HEME B | 1v5h | A | Q77 H81 H113 | FC6 | FERRICYANIDE | 1urv | A | R155 | FC6 | FERRICYANIDE | 1urv | B | R155 | FC6 | FERRICYANIDE | 1ury | A | R155 | XE | XENON(0) | 1ury | A | R155 | XE | XENON(0) | 1ury | B | R155 | FC6 | FERRICYANIDE | 1ury | B | R155 | FC6 | FERRICYANIDE | 1ut0 | A | R155 | FC6 | FERRICYANIDE | 1ut0 | B | R155 | XE | XENON(0) | 1ux9 | A | R155 | FC6 | FERRICYANIDE | 1ux9 | A | R155 | XE | XENON(0) | 1ux9 | B | R155 | FC6 | FERRICYANIDE | 1ux9 | B | R155 | FC6 | FERRICYANIDE | 4b3w | A | R155 | FC6 | FERRICYANIDE | 4b3w | B | R155 |
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Conservation information for LBS of CYGB |
Multiple alignments for Q8WWM9 in multiple species |
LBS | AA sequence | # species | Species | A112 | ALVGKAHALKH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A56 | VNFPSAKQYFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A88 | CRVMGALNTVV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F124 | VEPMYFKILSG | 2 | Mus musculus, Rattus norvegicus | F124 | VEPVYFKILSG | 1 | Homo sapiens | F49 | AILVRFFVNFP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F53 | RFFVNFPSAKQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F60 | SAKQYFSQFKH | 2 | Homo sapiens, Rattus norvegicus | F60 | SAKQYFSQFRH | 1 | Mus musculus | G156 | WAKLRGLIYSH | 2 | Homo sapiens, Mus musculus | G156 | WTKLRGLIYSH | 1 | Rattus norvegicus | G42 | NCEDVGVAILV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H113 | LVGKAHALKHK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H117 | AHALKHKVEPM | 2 | Mus musculus, Rattus norvegicus | H117 | AHALKHKVEPV | 1 | Homo sapiens | H81 | PQLRKHACRVM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I131 | ILSGVILEVVA | 1 | Homo sapiens | I131 | ILSGVILEVIA | 1 | Mus musculus | I131 | ILSGVILDVIA | 1 | Rattus norvegicus | I158 | KLRGLIYSHVT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I45 | DVGVAILVRFF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K116 | KAHALKHKVEP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K125 | EPMYFKILSGV | 2 | Mus musculus, Rattus norvegicus | K125 | EPVYFKILSGV | 1 | Homo sapiens | L127 | MYFKILSGVIL | 2 | Mus musculus, Rattus norvegicus | L127 | VYFKILSGVIL | 1 | Homo sapiens | L132 | LSGVILEVVAE | 1 | Homo sapiens | L132 | LSGVILEVIAE | 1 | Mus musculus | L132 | LSGVILDVIAE | 1 | Rattus norvegicus | L154 | RAWAKLRGLIY | 1 | Homo sapiens | L154 | KAWAKLRGLIY | 1 | Mus musculus | L154 | KAWTKLRGLIY | 1 | Rattus norvegicus | L46 | VGVAILVRFFV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L89 | RVMGALNTVVE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M86 | HACRVMGALNT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P54 | FFVNFPSAKQY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q62 | KQYFSQFKHME | 2 | Homo sapiens, Rattus norvegicus | Q62 | KQYFSQFRHME | 1 | Mus musculus | Q77 | MERSPQLRKHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R155 | AWAKLRGLIYS | 2 | Homo sapiens, Mus musculus | R155 | AWTKLRGLIYS | 1 | Rattus norvegicus | R84 | RKHACRVMGAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S128 | YFKILSGVILE | 2 | Homo sapiens, Mus musculus | S128 | YFKILSGVILD | 1 | Rattus norvegicus | S55 | FVNFPSAKQYF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V109 | SVLALVGKAHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V119 | ALKHKVEPMYF | 2 | Mus musculus, Rattus norvegicus | V119 | ALKHKVEPVYF | 1 | Homo sapiens | V41 | ANCEDVGVAIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V85 | KHACRVMGALN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V93 | ALNTVVENLHD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W151 | ETQRAWAKLRG | 1 | Homo sapiens | W151 | ETQKAWAKLRG | 1 | Mus musculus | W151 | ETQKAWTKLRG | 1 | Rattus norvegicus | W31 | AVQATWARLYA | 2 | Mus musculus, Rattus norvegicus | W31 | AVQAMWARLYA | 1 | Homo sapiens | Y123 | KVEPMYFKILS | 2 | Mus musculus, Rattus norvegicus | Y123 | KVEPVYFKILS | 1 | Homo sapiens | Y159 | LRGLIYSHVTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y59 | PSAKQYFSQFK | 2 | Homo sapiens, Rattus norvegicus | Y59 | PSAKQYFSQFR | 1 | Mus musculus |
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