mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CKS1B
Gene summary
Basic gene Info.Gene symbolCKS1B
Gene nameCDC28 protein kinase regulatory subunit 1B
SynonymsCKS1|PNAS-16|PNAS-18|ckshs1
CytomapUCSC genome browser: 1q21.2
Type of geneprotein-coding
RefGenesNM_001826.2,
NR_024163.1,
DescriptionCDC2-associated protein CKS1CDC28 protein kinase 1CDC28 protein kinase 1BCKS-1NB4 apoptosis/differentiation related proteinPNAS-143cell division control protein CKS1cyclin-dependent kinases regulatory subunit 1
Modification date20141207
dbXrefs MIM : 116900
HGNC : HGNC
Ensembl : ENSG00000173207
HPRD : 00299
Vega : OTTHUMG00000037413
ProteinUniProt: P61024
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CKS1B
BioGPS: 1163
PathwayNCI Pathway Interaction Database: CKS1B
KEGG: CKS1B
REACTOME: CKS1B
Pathway Commons: CKS1B
ContextiHOP: CKS1B
ligand binding site mutation search in PubMed: CKS1B
UCL Cancer Institute: CKS1B
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CKS1B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y8Y7CLUSC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CKS1B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y8Y7C-1.2693859
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CKS1B from PDB

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Differential gene expression and gene-gene network for CKS1B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CKS1B and the right PPI network was created from samples without mutations in the LBS of CKS1B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CKS1B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CKS1B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02681Meta VanadateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CKS1B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of CKS1B
Multiple alignments for P61024 in multiple species
LBSAA sequence# speciesSpecies
H56SQGWVHYMIHE3Homo sapiens, Bos taurus, Mus musculus
H56SPGWMHYMIHG1Caenorhabditis elegans
K11IYYSDKYDDEE3Homo sapiens, Bos taurus, Mus musculus
K11FYYSNKYEDDE1Caenorhabditis elegans
L37VPKTHLMSESE3Homo sapiens, Bos taurus, Mus musculus
L37IPKNRLMSETE1Caenorhabditis elegans
M38PKTHLMSESEW3Homo sapiens, Bos taurus, Mus musculus
M38PKNRLMSETEW1Caenorhabditis elegans
Q49RNLGVQQSQGW3Homo sapiens, Bos taurus, Mus musculus
Q49RSLGIQQSPGW1Caenorhabditis elegans
Q50NLGVQQSQGWV3Homo sapiens, Bos taurus, Mus musculus
Q50SLGIQQSPGWM1Caenorhabditis elegans
Q52GVQQSQGWVHY3Homo sapiens, Bos taurus, Mus musculus
Q52GIQQSPGWMHY1Caenorhabditis elegans
R20EEFEYRHVMLP3Homo sapiens, Bos taurus, Mus musculus
R20DEFEYRHVHVT1Caenorhabditis elegans
R44SESEWRNLGVQ3Homo sapiens, Bos taurus, Mus musculus
R44SETEWRSLGIQ1Caenorhabditis elegans
R71ILLFRRPLPKK3Homo sapiens, Bos taurus, Mus musculus
R71VLLFRRPLAAT1Caenorhabditis elegans
S39KTHLMSESEWR3Homo sapiens, Bos taurus, Mus musculus
S39KNRLMSETEWR1Caenorhabditis elegans
S51LGVQQSQGWVH3Homo sapiens, Bos taurus, Mus musculus
S51LGIQQSPGWMH1Caenorhabditis elegans
W54QQSQGWVHYMI3Homo sapiens, Bos taurus, Mus musculus
W54QQSPGWMHYMI1Caenorhabditis elegans
Y8HKQIYYSDKYD3Homo sapiens, Bos taurus, Mus musculus
Y8NNDFYYSNKYE1Caenorhabditis elegans


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