mutLBSgeneDB |
Gene summary for CKS1B |
Gene summary |
Basic gene Info. | Gene symbol | CKS1B |
Gene name | CDC28 protein kinase regulatory subunit 1B | |
Synonyms | CKS1|PNAS-16|PNAS-18|ckshs1 | |
Cytomap | UCSC genome browser: 1q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001826.2, NR_024163.1, | |
Description | CDC2-associated protein CKS1CDC28 protein kinase 1CDC28 protein kinase 1BCKS-1NB4 apoptosis/differentiation related proteinPNAS-143cell division control protein CKS1cyclin-dependent kinases regulatory subunit 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 116900 | |
HGNC : HGNC | ||
Ensembl : ENSG00000173207 | ||
HPRD : 00299 | ||
Vega : OTTHUMG00000037413 | ||
Protein | UniProt: P61024 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CKS1B | |
BioGPS: 1163 | ||
Pathway | NCI Pathway Interaction Database: CKS1B | |
KEGG: CKS1B | ||
REACTOME: CKS1B | ||
Pathway Commons: CKS1B | ||
Context | iHOP: CKS1B | |
ligand binding site mutation search in PubMed: CKS1B | ||
UCL Cancer Institute: CKS1B | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CKS1B |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Y8 | Y7C | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CKS1B |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y8 | Y7C | -1.2693859 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CKS1B from PDB |
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Differential gene expression and gene-gene network for CKS1B |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CKS1B |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CKS1B |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB02681 | Meta Vanadate | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CKS1B go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CKS1B |
Multiple alignments for P61024 in multiple species |
LBS | AA sequence | # species | Species | H56 | SQGWVHYMIHE | 3 | Homo sapiens, Bos taurus, Mus musculus | H56 | SPGWMHYMIHG | 1 | Caenorhabditis elegans | K11 | IYYSDKYDDEE | 3 | Homo sapiens, Bos taurus, Mus musculus | K11 | FYYSNKYEDDE | 1 | Caenorhabditis elegans | L37 | VPKTHLMSESE | 3 | Homo sapiens, Bos taurus, Mus musculus | L37 | IPKNRLMSETE | 1 | Caenorhabditis elegans | M38 | PKTHLMSESEW | 3 | Homo sapiens, Bos taurus, Mus musculus | M38 | PKNRLMSETEW | 1 | Caenorhabditis elegans | Q49 | RNLGVQQSQGW | 3 | Homo sapiens, Bos taurus, Mus musculus | Q49 | RSLGIQQSPGW | 1 | Caenorhabditis elegans | Q50 | NLGVQQSQGWV | 3 | Homo sapiens, Bos taurus, Mus musculus | Q50 | SLGIQQSPGWM | 1 | Caenorhabditis elegans | Q52 | GVQQSQGWVHY | 3 | Homo sapiens, Bos taurus, Mus musculus | Q52 | GIQQSPGWMHY | 1 | Caenorhabditis elegans | R20 | EEFEYRHVMLP | 3 | Homo sapiens, Bos taurus, Mus musculus | R20 | DEFEYRHVHVT | 1 | Caenorhabditis elegans | R44 | SESEWRNLGVQ | 3 | Homo sapiens, Bos taurus, Mus musculus | R44 | SETEWRSLGIQ | 1 | Caenorhabditis elegans | R71 | ILLFRRPLPKK | 3 | Homo sapiens, Bos taurus, Mus musculus | R71 | VLLFRRPLAAT | 1 | Caenorhabditis elegans | S39 | KTHLMSESEWR | 3 | Homo sapiens, Bos taurus, Mus musculus | S39 | KNRLMSETEWR | 1 | Caenorhabditis elegans | S51 | LGVQQSQGWVH | 3 | Homo sapiens, Bos taurus, Mus musculus | S51 | LGIQQSPGWMH | 1 | Caenorhabditis elegans | W54 | QQSQGWVHYMI | 3 | Homo sapiens, Bos taurus, Mus musculus | W54 | QQSPGWMHYMI | 1 | Caenorhabditis elegans | Y8 | HKQIYYSDKYD | 3 | Homo sapiens, Bos taurus, Mus musculus | Y8 | NNDFYYSNKYE | 1 | Caenorhabditis elegans |
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