mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for THEM4
Gene summary
Basic gene Info.Gene symbolTHEM4
Gene namethioesterase superfamily member 4
SynonymsCTMP
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_053055.4,
NM_176853.2,
DescriptionC-terminal modulator proteinacyl-CoA thioesterase THEM4acyl-coenzyme A thioesterase THEM4carboxyl-terminal modulator protein
Modification date20141211
dbXrefs MIM : 606388
HGNC : HGNC
HPRD : 16215
ProteinUniProt: Q5T1C6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_THEM4
BioGPS: 117145
PathwayNCI Pathway Interaction Database: THEM4
KEGG: THEM4
REACTOME: THEM4
Pathway Commons: THEM4
ContextiHOP: THEM4
ligand binding site mutation search in PubMed: THEM4
UCL Cancer Institute: THEM4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006631fatty acid metabolic process22871024


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Ligand binding site mutations for THEM4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
N183N183KCOAD1
W86E85KLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for THEM4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N183N183K-1.6548789
W86E85K-1.0475993
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for THEM4 from PDB

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Differential gene expression and gene-gene network for THEM4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of THEM4 and the right PPI network was created from samples without mutations in the LBS of THEM4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for THEM4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for THEM4
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of THEM4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
0ETUNDECAN-2-ONE-COA[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3- OXIDANYLIDENE-3-[2-[(2R)-2- OXIDANYLUNDECYL]SULFANYLETHYLAMINO]PROPYL]AMINO]BUTYL] HYDROGEN PHOS4gahAN183
0ETUNDECAN-2-ONE-COA[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3- OXIDANYLIDENE-3-[2-[(2R)-2- OXIDANYLUNDECYL]SULFANYLETHYLAMINO]PROPYL]AMINO]BUTYL] HYDROGEN PHOS4gahBN183
0ETUNDECAN-2-ONE-COA[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3- PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3- OXIDANYLIDENE-3-[2-[(2R)-2- OXIDANYLUNDECYL]SULFANYLETHYLAMINO]PROPYL]AMINO]BUTYL] HYDROGEN PHOS4gahBW86


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Conservation information for LBS of THEM4
Multiple alignments for Q5T1C6 in multiple species
LBSAA sequence# speciesSpecies
A178GIVMTANLNIN1Homo sapiens
A178GAVMTANLNIN1Bos taurus
A178GVAMTANLNIT1Mus musculus
A178GIVMTANLNID1Rattus norvegicus
D161IATMIDATVGM1Homo sapiens
D161MATMIDIALGS1Bos taurus
D161IATIIDVTTGT1Mus musculus
D161IATIIDITAGM1Rattus norvegicus
G146GPYLEGPPGFI1Homo sapiens
G146GPYLQGVPGLL1Bos taurus
G146GLHLQGVPGFV1Mus musculus
G146GLHLQGMPGFV1Rattus norvegicus
G153PGFVHGGAIAT2Mus musculus, Rattus norvegicus
G153PGFIHGGAIAT1Homo sapiens
G153PGLLHGGAMAT1Bos taurus
H152PPGFIHGGAIA1Homo sapiens
H152VPGLLHGGAMA1Bos taurus
H152VPGFVHGGAIA1Mus musculus
H152MPGFVHGGAIA1Rattus norvegicus
H93QDFKTHFLDPK1Homo sapiens
H93EDFKTYFLDPK1Bos taurus
H93QEFQTLFVDSK1Mus musculus
H93QEFQTHFVDSK1Rattus norvegicus
I174MMAGGIVMTAN1Homo sapiens
I174---GGAVMTAN1Bos taurus
I174-ISEGVAMTAN1Mus musculus
I174-FSEGIVMTAN1Rattus norvegicus
I231ATSLFIKLNPA1Homo sapiens
I231ATGLFIKLDPE1Bos taurus
I231ATALFIKLDPE1Mus musculus
I231ATALFIKLDPD1Rattus norvegicus
K185LNINYKRPIPL1Homo sapiens
K185LNINFKRPVPL1Bos taurus
K185LNITYKKPIPL1Mus musculus
K185LNIDYKKPIPL1Rattus norvegicus
K207KIEGRKLFVSC2Mus musculus, Rattus norvegicus
K207KVEGRKFFVSC1Homo sapiens
K207KLEGRKLFLSC1Bos taurus
L229SEATSLFIKLN1Homo sapiens
L229SEATGLFIKLD1Bos taurus
L229TEATALFIKLD1Mus musculus
L229TQATALFIKLD1Rattus norvegicus
L233SLFIKLNPAKS1Homo sapiens
L233GLFIKLDPEKS1Bos taurus
L233ALFIKLDPEKP1Mus musculus
L233ALFIKLDPDKP1Rattus norvegicus
M169VGMCAMMAGGI1Homo sapiens
M169LGSCT---GGA1Bos taurus
M169TGTCA-ISEGV1Mus musculus
M169AGMCA-FSEGI1Rattus norvegicus
M170GMCAMMAGGIV1Homo sapiens
M170GSCT---GGAV1Bos taurus
M170GTCA-ISEGVA1Mus musculus
M170GMCA-FSEGIV1Rattus norvegicus
M176AGGIVMTANLN1Homo sapiens
M176-GGAVMTANLN1Bos taurus
M176SEGVAMTANLN1Mus musculus
M176SEGIVMTANLN1Rattus norvegicus
N183ANLNINYKRPI1Homo sapiens
N183ANLNINFKRPV1Bos taurus
N183ANLNITYKKPI1Mus musculus
N183ANLNIDYKKPI1Rattus norvegicus
P147PYLEGPPGFIH1Homo sapiens
P147PYLQGVPGLLH1Bos taurus
P147LHLQGVPGFVH1Mus musculus
P147LHLQGMPGFVH1Rattus norvegicus
P187INYKRPIPLCS1Homo sapiens
P187INFKRPVPLCS1Bos taurus
P187ITYKKPIPLLS1Mus musculus
P187IDYKKPIPLLS1Rattus norvegicus
R186NINYKRPIPLC1Homo sapiens
R186NINFKRPVPLC1Bos taurus
R186NITYKKPIPLL1Mus musculus
R186NIDYKKPIPLL1Rattus norvegicus
R206QKIEGRKLFVS2Mus musculus, Rattus norvegicus
R206DKVEGRKFFVS1Homo sapiens
R206DKLEGRKLFLS1Bos taurus
T177GGIVMTANLNI1Homo sapiens
T177GGAVMTANLNI1Bos taurus
T177EGVAMTANLNI1Mus musculus
T177EGIVMTANLNI1Rattus norvegicus
W86RTPTEWIQDFK1Homo sapiens
W86RRSTQESEDFK1Bos taurus
W86QNPTRAIQEFQ1Mus musculus
W86QNPPQALQEFQ1Rattus norvegicus
Y184NLNINYKRPIP1Homo sapiens
Y184NLNINFKRPVP1Bos taurus
Y184NLNITYKKPIP1Mus musculus
Y184NLNIDYKKPIP1Rattus norvegicus


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