mutLBSgeneDB |
Gene summary for CPN1 |
Gene summary |
Basic gene Info. | Gene symbol | CPN1 |
Gene name | carboxypeptidase N, polypeptide 1 | |
Synonyms | CPN|SCPN | |
Cytomap | UCSC genome browser: 10q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001308.2, | |
Description | anaphylatoxin inactivatorarginine carboxypeptidasecarboxypeptidase Kcarboxypeptidase N catalytic chaincarboxypeptidase N catalytic subunitcarboxypeptidase N polypeptide 1 50 kDcarboxypeptidase N small subunitkininase Ikininase-1lysine carboxypept | |
Modification date | 20141207 | |
dbXrefs | MIM : 603103 | |
HGNC : HGNC | ||
Ensembl : ENSG00000120054 | ||
HPRD : 09120 | ||
Vega : OTTHUMG00000018896 | ||
Protein | UniProt: P15169 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CPN1 | |
BioGPS: 1369 | ||
Pathway | NCI Pathway Interaction Database: CPN1 | |
KEGG: CPN1 | ||
REACTOME: CPN1 | ||
Pathway Commons: CPN1 | ||
Context | iHOP: CPN1 | |
ligand binding site mutation search in PubMed: CPN1 | ||
UCL Cancer Institute: CPN1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CPN1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | G404,T402 | V403M | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CPN1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G404 | V403M | -0.26299873 | T402 | V403M | -0.26299873 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CPN1 from PDB |
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Differential gene expression and gene-gene network for CPN1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CPN1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0398782 | Carboxypeptidase N Deficiency | 1 | Biomarker, GeneticVariation |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CPN1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CPN1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CPN1 |
Multiple alignments for P15169 in multiple species |
LBS | AA sequence | # species | Species | G404 | VTVTVGPAGPT | 2 | Mus musculus, Rattus norvegicus | G404 | VTVTVGPAEPT | 1 | Homo sapiens | G404 | VSVTVGPAEPK | 1 | Bos taurus | I384 | LLLPGTYSVTA | 2 | Mus musculus, Rattus norvegicus | I384 | LLLPGIYTVSA | 1 | Homo sapiens | I384 | LLLPGTYTVTA | 1 | Bos taurus | T400 | DPETVTVTVGP | 1 | Homo sapiens | T400 | DPKTVTVTVGP | 1 | Mus musculus | T400 | EPKTVTVTVGP | 1 | Rattus norvegicus | T400 | DPETVSVTVGP | 1 | Bos taurus | T402 | KTVTVTVGPAG | 2 | Mus musculus, Rattus norvegicus | T402 | ETVTVTVGPAE | 1 | Homo sapiens | T402 | ETVSVTVGPAE | 1 | Bos taurus | T409 | GPAEPTLVNFH | 1 | Homo sapiens | T409 | GPAGPTVVDFQ | 1 | Mus musculus | T409 | GPAGPTLVDFQ | 1 | Rattus norvegicus | T409 | GPAEPKLVNFQ | 1 | Bos taurus |
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