mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CPN1
Gene summary
Basic gene Info.Gene symbolCPN1
Gene namecarboxypeptidase N, polypeptide 1
CytomapUCSC genome browser: 10q24.2
Type of geneprotein-coding
Descriptionanaphylatoxin inactivatorarginine carboxypeptidasecarboxypeptidase Kcarboxypeptidase N catalytic chaincarboxypeptidase N catalytic subunitcarboxypeptidase N polypeptide 1 50 kDcarboxypeptidase N small subunitkininase Ikininase-1lysine carboxypept
Modification date20141207
dbXrefs MIM : 603103
Ensembl : ENSG00000120054
HPRD : 09120
Vega : OTTHUMG00000018896
ProteinUniProt: P15169
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CPN1
BioGPS: 1369
PathwayNCI Pathway Interaction Database: CPN1
Pathway Commons: CPN1
ContextiHOP: CPN1
ligand binding site mutation search in PubMed: CPN1
UCL Cancer Institute: CPN1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CPN1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CPN1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CPN1 from PDB

Differential gene expression and gene-gene network for CPN1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CPN1 and the right PPI network was created from samples without mutations in the LBS of CPN1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CPN1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0398782Carboxypeptidase N Deficiency1Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CPN1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CPN1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CPN1
Multiple alignments for P15169 in multiple species
LBSAA sequence# speciesSpecies
G404VTVTVGPAGPT2Mus musculus, Rattus norvegicus
G404VTVTVGPAEPT1Homo sapiens
G404VSVTVGPAEPK1Bos taurus
I384LLLPGTYSVTA2Mus musculus, Rattus norvegicus
I384LLLPGIYTVSA1Homo sapiens
I384LLLPGTYTVTA1Bos taurus
T400DPETVTVTVGP1Homo sapiens
T400DPKTVTVTVGP1Mus musculus
T400EPKTVTVTVGP1Rattus norvegicus
T400DPETVSVTVGP1Bos taurus
T402KTVTVTVGPAG2Mus musculus, Rattus norvegicus
T402ETVTVTVGPAE1Homo sapiens
T402ETVSVTVGPAE1Bos taurus
T409GPAEPTLVNFH1Homo sapiens
T409GPAGPTVVDFQ1Mus musculus
T409GPAGPTLVDFQ1Rattus norvegicus
T409GPAEPKLVNFQ1Bos taurus

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