mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CSNK2A2
Gene summary
Basic gene Info.Gene symbolCSNK2A2
Gene namecasein kinase 2, alpha prime polypeptide
CytomapUCSC genome browser: 16q21
Type of geneprotein-coding
DescriptionCK II alpha'casein kinase II subunit alpha'
Modification date20141207
dbXrefs MIM : 115442
Ensembl : ENSG00000070770
HPRD : 00279
Vega : OTTHUMG00000133488
ProteinUniProt: P19784
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CSNK2A2
BioGPS: 1459
PathwayNCI Pathway Interaction Database: CSNK2A2
Pathway Commons: CSNK2A2
ContextiHOP: CSNK2A2
ligand binding site mutation search in PubMed: CSNK2A2
UCL Cancer Institute: CSNK2A2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CSNK2A2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CSNK2A2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CSNK2A2 from PDB

Differential gene expression and gene-gene network for CSNK2A2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CSNK2A2 and the right PPI network was created from samples without mutations in the LBS of CSNK2A2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CSNK2A2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007137Carcinoma, Squamous Cell1Biomarker
umls:C0037286Skin Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CSNK2A2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB07546[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CSNK2A2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of CSNK2A2
Multiple alignments for P19784 in multiple species
LBSAA sequence# speciesSpecies
D176KLRLIDWGLAE5Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Mus musculus, Bos taurus
E115PALVFEYINNT3Homo sapiens, Mus musculus, Bos taurus
E115PALVFEYVDNV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E115PSLVFEFVNSV1Arabidopsis thaliana
F114TPALVFEYINN3Homo sapiens, Mus musculus, Bos taurus
F114TPALVFEYVDN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F114TPSLVFEFVNS1Arabidopsis thaliana
G49RKLGRGKYSEV3Homo sapiens, Mus musculus, Bos taurus
G49NKVGRGKYSEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G49RKVGRGKYSEV1Arabidopsis thaliana
H161RDVKPHNVMID5Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Mus musculus, Bos taurus
I117LVFEYINNTDF3Homo sapiens, Mus musculus, Bos taurus
I117LVFEYVDNVDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I117LVFEFVNSVDF1Arabidopsis thaliana
I175KKLRLIDWGLA4Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Bos taurus
I175RKLRLIDWGLA1Arabidopsis thaliana
I96GGTNIIKLIDT3Homo sapiens, Mus musculus, Bos taurus
I96GHANIIHLFDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I96GGPNIVKLYDI1Arabidopsis thaliana
K69ERVVVKILKPV3Homo sapiens, Mus musculus, Bos taurus
K69VKIVIKMLKPV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K69ERCVIKILKPV1Arabidopsis thaliana
L46QLVRKLGRGKY3Homo sapiens, Mus musculus, Bos taurus
L46EIENKVGRGKY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L46EVVRKVGRGKY1Arabidopsis thaliana
M164KPHNVMIDHQQ3Homo sapiens, Mus musculus, Bos taurus
M164KPHNVMIDHKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M164KPHNVMIDHQL1Arabidopsis thaliana
N162DVKPHNVMIDH5Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Mus musculus, Bos taurus
R44DYQLVRKLGRG3Homo sapiens, Mus musculus, Bos taurus
R44DYEIENKVGRG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R44DYEVVRKVGRG1Arabidopsis thaliana
S52GRGKYSEVFEA3Homo sapiens, Mus musculus, Bos taurus
S52GRGKYSEVFQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S52GRGKYSEVFEG1Arabidopsis thaliana
V54GKYSEVFEAIN3Homo sapiens, Mus musculus, Bos taurus
V54GKYSEVFQGVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V54GKYSEVFEGKN1Arabidopsis thaliana
V67NNERVVVKILK3Homo sapiens, Mus musculus, Bos taurus
V67SKVKIVIKMLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V67TNERCVIKILK1Arabidopsis thaliana
Y116ALVFEYINNTD3Homo sapiens, Mus musculus, Bos taurus
Y116ALVFEYVDNVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y116SLVFEFVNSVD1Arabidopsis thaliana

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