mutLBSgeneDB |
Gene summary for CTBP1 |
Gene summary |
Basic gene Info. | Gene symbol | CTBP1 |
Gene name | C-terminal binding protein 1 | |
Synonyms | BARS | |
Cytomap | UCSC genome browser: 4p16 | |
Type of gene | protein-coding | |
RefGenes | NM_001012614.1, NM_001328.2, | |
Description | C-terminal-binding protein 1brefeldin A-ribosylated substrate | |
Modification date | 20141207 | |
dbXrefs | MIM : 602618 | |
HGNC : HGNC | ||
Ensembl : ENSG00000159692 | ||
HPRD : 04015 | ||
Vega : OTTHUMG00000089259 | ||
Protein | UniProt: Q13363 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CTBP1 | |
BioGPS: 1487 | ||
Pathway | NCI Pathway Interaction Database: CTBP1 | |
KEGG: CTBP1 | ||
REACTOME: CTBP1 | ||
Pathway Commons: CTBP1 | ||
Context | iHOP: CTBP1 | |
ligand binding site mutation search in PubMed: CTBP1 | ||
UCL Cancer Institute: CTBP1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CTBP1 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | T264,F260 | V262M | COAD | 1 | R266 | R266W | COAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CTBP1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R266 | R266W | -0.99314632 | F260 | V262M | -0.49227336 | T264 | V262M | -0.49227336 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CTBP1 from PDB |
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Differential gene expression and gene-gene network for CTBP1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CTBP1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0009404 | Colorectal Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CTBP1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB01942 | Formic Acid | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CTBP1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FMT | FORMIC ACID | 4u6s | A | F260 | KMT | 4-METHYLTHIO-2-OXOBUTANOIC ACID | 4lce | A | R266 | 3CR | (2E)-2-(HYDROXYIMINO)-3-PHENYLPROPANOIC ACID | 4u6q | A | R266 | PPY | KETO-PHENYLPYRUVIC ACID | 4u6s | A | R266 | NAD | NAD ZWITTERION | 1mx3 | A | T264 R266 | NAD | NAD ZWITTERION | 4lce | A | T264 R266 | NAI | NADH | 4u6q | A | T264 R266 | NAD | NAD ZWITTERION | 4u6s | A | T264 R266 |
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Conservation information for LBS of CTBP1 |
Multiple alignments for Q13363 in multiple species |
LBS | AA sequence | # species | Species | A265 | FLVNTARGGLV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A265 | YIVNTSHAGLI | 1 | Caenorhabditis elegans | A317 | CTPHAAWYSEQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A317 | NTPHSAWMTEA | 1 | Caenorhabditis elegans | C237 | CVTLHCGLNEH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C237 | CISLHCNLGDE | 1 | Caenorhabditis elegans | D204 | NVLFYDPYLSD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D204 | HIIFYDPFVRE | 1 | Caenorhabditis elegans | D231 | LLFHSDCVTLH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D231 | FMSRSDCISLH | 1 | Caenorhabditis elegans | D290 | RGAALDVHESE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D290 | KGAALDVHDSV | 1 | Caenorhabditis elegans | E175 | ARIRGETLGII | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E175 | KKVRGSVLGIL | 1 | Caenorhabditis elegans | F260 | MRQGAFLVNTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F260 | CKSGVYIVNTS | 1 | Caenorhabditis elegans | G101 | VRIGSGFDNID | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G101 | FRIGYGIDNID | 1 | Caenorhabditis elegans | G181 | TLGIIGLGRVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G181 | VLGILGCGRVG | 1 | Caenorhabditis elegans | G183 | GIIGLGRVGQA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G183 | GILGCGRVGTA | 1 | Caenorhabditis elegans | G238 | VTLHCGLNEHN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G238 | ISLHCNLGDET | 1 | Caenorhabditis elegans | G258 | KQMRQGAFLVN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G258 | RQCKSGVYIVN | 1 | Caenorhabditis elegans | G99 | IIVRIGSGFDN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G99 | VVFRIGYGIDN | 1 | Caenorhabditis elegans | H236 | DCVTLHCGLNE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H236 | DCISLHCNLGD | 1 | Caenorhabditis elegans | H315 | LICTPHAAWYS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H315 | IINTPHSAWMT | 1 | Caenorhabditis elegans | H77 | GALMYHTITLT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H77 | AALMYHSIKLE | 1 | Caenorhabditis elegans | I180 | ETLGIIGLGRV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I180 | SVLGILGCGRV | 1 | Caenorhabditis elegans | I98 | RIIVRIGSGFD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I98 | KVVFRIGYGID | 1 | Caenorhabditis elegans | L207 | FYDPYLSDGIE | 2 | Mus musculus, Rattus norvegicus | L207 | FYDPYLSDGVE | 1 | Homo sapiens | L207 | FYDPFVREGHD | 1 | Caenorhabditis elegans | M327 | QASIEMREEAA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M327 | ASCKDLRINAA | 1 | Caenorhabditis elegans | N240 | LHCGLNEHNHH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N240 | LHCNLGDETRG | 1 | Caenorhabditis elegans | N243 | GLNEHNHHLIN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N243 | NLGDETRGIIN | 1 | Caenorhabditis elegans | P205 | VLFYDPYLSDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P205 | IIFYDPFVREG | 1 | Caenorhabditis elegans | R184 | IIGLGRVGQAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R184 | ILGCGRVGTAV | 1 | Caenorhabditis elegans | R266 | LVNTARGGLVD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R266 | IVNTSHAGLIN | 1 | Caenorhabditis elegans | R285 | KEGRIRGAALD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R285 | KNGHVKGAALD | 1 | Caenorhabditis elegans | R97 | LRIIVRIGSGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R97 | LKVVFRIGYGI | 1 | Caenorhabditis elegans | S100 | IVRIGSGFDNI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S100 | VFRIGYGIDNI | 1 | Caenorhabditis elegans | T128 | ASVEETADSTL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T128 | DYVEDVADSTL | 1 | Caenorhabditis elegans | T264 | AFLVNTARGGL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T264 | VYIVNTSHAGL | 1 | Caenorhabditis elegans | V185 | IGLGRVGQAVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V185 | LGCGRVGTAVG | 1 | Caenorhabditis elegans | V291 | GAALDVHESEP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V291 | GAALDVHDSVR | 1 | Caenorhabditis elegans | W318 | TPHAAWYSEQA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W318 | TPHSAWMTEAS | 1 | Caenorhabditis elegans | Y203 | FNVLFYDPYLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y203 | LHIIFYDPFVR | 1 | Caenorhabditis elegans | Y206 | LFYDPYLSDGI | 2 | Mus musculus, Rattus norvegicus | Y206 | LFYDPYLSDGV | 1 | Homo sapiens | Y206 | IFYDPFVREGH | 1 | Caenorhabditis elegans | Y76 | VGALMYHTITL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y76 | VAALMYHSIKL | 1 | Caenorhabditis elegans |
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