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mutLBSgeneDB |
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| Gene summary for CTBP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | CTBP2 |
| Gene name | C-terminal binding protein 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 10q26.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001083914.1, NM_001290214.1,NM_001290215.1,NM_001329.2,NM_022802.2, | |
| Description | C-terminal-binding protein 2ribeye | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602619 | |
| HGNC : HGNC | ||
| HPRD : 04016 | ||
| Protein | UniProt: P56545 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CTBP2 | |
| BioGPS: 1488 | ||
| Pathway | NCI Pathway Interaction Database: CTBP2 | |
| KEGG: CTBP2 | ||
| REACTOME: CTBP2 | ||
| Pathway Commons: CTBP2 | ||
| Context | iHOP: CTBP2 | |
| ligand binding site mutation search in PubMed: CTBP2 | ||
| UCL Cancer Institute: CTBP2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CTBP2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V297 | H298N | KIRC | 1 | H242 | H242Y | STAD | 1 | Y212 | Y212C | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CTBP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y212 | Y212C | -1.2015599 | H242 | H242Y | -0.60002224 | V297 | H298N | -0.55166891 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CTBP2 from PDB |
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| Differential gene expression and gene-gene network for CTBP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CTBP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CTBP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CTBP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAD | NAD ZWITTERION | 2ome | B | Y212 H242 | NAD | NAD ZWITTERION | 2ome | C | Y212 H242 | NAD | NAD ZWITTERION | 2ome | F | Y212 H242 | NAD | NAD ZWITTERION | 4lcj | A | Y212 H242 | NAD | NAD ZWITTERION | 4lcj | D | Y212 H242 | NAD | NAD ZWITTERION | 4lcj | E | Y212 H242 | NAD | NAD ZWITTERION | 4lcj | G | Y212 H242 | NAD | NAD ZWITTERION | 2ome | A | Y212 H242 V297 | NAD | NAD ZWITTERION | 2ome | D | Y212 H242 V297 | NAD | NAD ZWITTERION | 2ome | E | Y212 H242 V297 | NAD | NAD ZWITTERION | 2ome | G | Y212 H242 V297 | NAD | NAD ZWITTERION | 2ome | H | Y212 H242 V297 | NAD | NAD ZWITTERION | 4lcj | B | Y212 H242 V297 | NAD | NAD ZWITTERION | 4lcj | C | Y212 H242 V297 | NAD | NAD ZWITTERION | 4lcj | F | Y212 H242 V297 | NAD | NAD ZWITTERION | 4lcj | H | Y212 H242 V297 |
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| Conservation information for LBS of CTBP2 |
| Multiple alignments for P56545 in multiple species |
| LBS | AA sequence | # species | Species | A270 | AFLVNAARGGL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A271 | FLVNAARGGLV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A323 | CTPHTAWYSEQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C243 | CVSLHCNLNEH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D210 | SVIFYDPYLQD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D210 | SVLFYDPYLQD | 1 | Bos taurus | D296 | RGAALDVHESE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G105 | VIVRIGSGYDN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G107 | VRIGSGYDNVD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G187 | TLGLIGFGRTG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G189 | GLIGFGRTGQA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H242 | DCVSLHCNLNE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H321 | LICTPHTAWYS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H83 | GAMMYHTITLT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I104 | RVIVRIGSGYD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I186 | ETLGLIGFGRT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L213 | FYDPYLQDGIE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L213 | FYDPYLQDGTE | 1 | Bos taurus | N244 | VSLHCNLNEHN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N246 | LHCNLNEHNHH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N249 | NLNEHNHHLIN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P211 | VIFYDPYLQDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P211 | VLFYDPYLQDG | 1 | Bos taurus | R103 | LRVIVRIGSGY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R190 | LIGFGRTGQAV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R272 | LVNAARGGLVD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S106 | IVRIGSGYDNV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T134 | AAVEETADSTI | 2 | Homo sapiens, Bos taurus | T134 | AAVEETADSTV | 2 | Mus musculus, Rattus norvegicus | T191 | IGFGRTGQAVA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V297 | GAALDVHESEP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W324 | TPHTAWYSEQA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y209 | FSVIFYDPYLQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y209 | FSVLFYDPYLQ | 1 | Bos taurus | Y212 | IFYDPYLQDGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y212 | LFYDPYLQDGT | 1 | Bos taurus | Y82 | VGAMMYHTITL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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