mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for METTL21A
Gene summary
Basic gene Info.Gene symbolMETTL21A
Gene namemethyltransferase like 21A
SynonymsFAM119A|HCA557b|HSPA-KMT
CytomapUCSC genome browser: 2q33.3
Type of geneprotein-coding
RefGenesNM_001127395.1,
NM_145280.4,
DescriptionHSPA lysine methyltransferasefamily with sequence similarity 119, member Aheat shock protein 70kDa lysine (K) methyltransferasehepatocellular carcinoma-associated antigen 557bmethyltransferase-like protein 21Aprotein N-lysine methyltransferase METTL2
Modification date20141207
dbXrefs MIM : 615257
HGNC : HGNC
Ensembl : ENSG00000144401
HPRD : 14090
ProteinUniProt: Q8WXB1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_METTL21A
BioGPS: 151194
PathwayNCI Pathway Interaction Database: METTL21A
KEGG: METTL21A
REACTOME: METTL21A
Pathway Commons: METTL21A
ContextiHOP: METTL21A
ligand binding site mutation search in PubMed: METTL21A
UCL Cancer Institute: METTL21A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006479protein methylation22948820
GO:0018022peptidyl-lysine methylation23921388
GO:0043462regulation of ATPase activity23921388


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Ligand binding site mutations for METTL21A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A50A49TCOAD1
D144D144NHNSC1
V42L40VSKCM1
R95R95QUCEC1
A50V52IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for METTL21A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R95R95Q-1.3591983
A50A49T-0.99359194
D144D144N-0.7719199
V42L40V-0.52506128
A50V52I-0.38046301
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for METTL21A from PDB

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Differential gene expression and gene-gene network for METTL21A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of METTL21A and the right PPI network was created from samples without mutations in the LBS of METTL21A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for METTL21A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for METTL21A
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of METTL21A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SAHS-ADENOSYL-L-HOMOCYSTEINE4lecAV42 A50 R95 D144
SAHS-ADENOSYL-L-HOMOCYSTEINE4lecBV42 A50 R95 D144


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Conservation information for LBS of METTL21A
Multiple alignments for Q8WXB1 in multiple species
LBSAA sequence# speciesSpecies
A143DLILGADIIYL2Homo sapiens, Bos taurus
A143DFILGADIIYL1Xenopus tropicalis
A143DLILGADIVYL1Danio rerio
A143DLILGADVIYL1Mus musculus
A43KQLGVAAVVWD2Xenopus tropicalis, Bos taurus
A43RHLGVAAVVWD1Homo sapiens
A43KRLGVAAVVWD1Danio rerio
A43RQLGVAAVVWD1Mus musculus
A50VVWDAAIVLST1Homo sapiens
A50VVWDAALVLCM1Xenopus tropicalis
A50VVWDAAVVLCM1Danio rerio
A50VVWDAAVVLAT1Bos taurus
A50VVWDAAVVLSM1Mus musculus
A74AVELGAGTGLV3Homo sapiens, Bos taurus, Mus musculus
A74VIELGAGTGLV2Xenopus tropicalis, Danio rerio
D144LILGADIIYLE2Homo sapiens, Bos taurus
D144FILGADIIYLE1Xenopus tropicalis
D144LILGADIVYLE1Danio rerio
D144LILGADVIYLE1Mus musculus
D94HVTITDRKVAL2Homo sapiens, Bos taurus
D94QVTITDRDLAM1Xenopus tropicalis
D94NVTITDREPAL1Danio rerio
D94QVTITDRKVAL1Mus musculus
G73SAVELGAGTGL3Homo sapiens, Bos taurus, Mus musculus
G73SVIELGAGTGL1Xenopus tropicalis
G73RVIELGAGTGL1Danio rerio
G75VELGAGTGLVG3Homo sapiens, Bos taurus, Mus musculus
G75IELGAGTGLVG2Xenopus tropicalis, Danio rerio
L123AVVKELTWGQN2Bos taurus, Mus musculus
L123TVVKELTWGQN1Homo sapiens
L123VSVRALNWGKS1Xenopus tropicalis
L123VQVSELTWGEN1Danio rerio
R95VTITDRKVALE3Homo sapiens, Bos taurus, Mus musculus
R95VTITDRDLAME1Xenopus tropicalis
R95VTITDREPALE1Danio rerio
T124VVKELTWGQNL3Homo sapiens, Bos taurus, Mus musculus
T124SVRALNWGKSL1Xenopus tropicalis
T124QVSELTWGENL1Danio rerio
V42WKQLGVAAVVW2Xenopus tropicalis, Bos taurus
V42WRHLGVAAVVW1Homo sapiens
V42WKRLGVAAVVW1Danio rerio
V42WRQLGVAAVVW1Mus musculus
V45LGVAAVVWDAA5Homo sapiens, Xenopus tropicalis, Danio rerio, Bos taurus, Mus musculus
V46GVAAVVWDAAV3Danio rerio, Bos taurus, Mus musculus
V46GVAAVVWDAAI1Homo sapiens
V46GVAAVVWDAAL1Xenopus tropicalis
W125VKELTWGQNLG2Homo sapiens, Bos taurus
W125VRALNWGKSLE1Xenopus tropicalis
W125VSELTWGENLD1Danio rerio
W125VKELTWGQNLE1Mus musculus
W47VAAVVWDAAVV3Danio rerio, Bos taurus, Mus musculus
W47VAAVVWDAAIV1Homo sapiens
W47VAAVVWDAALV1Xenopus tropicalis
Y147GADIIYLEETF3Homo sapiens, Xenopus tropicalis, Bos taurus
Y147GADIVYLEETF1Danio rerio
Y147GADVIYLEDTF1Mus musculus


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