mutLBSgeneDB |
Gene summary for METTL21A |
Gene summary |
Basic gene Info. | Gene symbol | METTL21A |
Gene name | methyltransferase like 21A | |
Synonyms | FAM119A|HCA557b|HSPA-KMT | |
Cytomap | UCSC genome browser: 2q33.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001127395.1, NM_145280.4, | |
Description | HSPA lysine methyltransferasefamily with sequence similarity 119, member Aheat shock protein 70kDa lysine (K) methyltransferasehepatocellular carcinoma-associated antigen 557bmethyltransferase-like protein 21Aprotein N-lysine methyltransferase METTL2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 615257 | |
HGNC : HGNC | ||
Ensembl : ENSG00000144401 | ||
HPRD : 14090 | ||
Protein | UniProt: Q8WXB1 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_METTL21A | |
BioGPS: 151194 | ||
Pathway | NCI Pathway Interaction Database: METTL21A | |
KEGG: METTL21A | ||
REACTOME: METTL21A | ||
Pathway Commons: METTL21A | ||
Context | iHOP: METTL21A | |
ligand binding site mutation search in PubMed: METTL21A | ||
UCL Cancer Institute: METTL21A | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006479 | protein methylation | 22948820 | GO:0018022 | peptidyl-lysine methylation | 23921388 | GO:0043462 | regulation of ATPase activity | 23921388 |
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Ligand binding site mutations for METTL21A |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | A50 | A49T | COAD | 1 | D144 | D144N | HNSC | 1 | V42 | L40V | SKCM | 1 | R95 | R95Q | UCEC | 1 | A50 | V52I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for METTL21A |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R95 | R95Q | -1.3591983 | A50 | A49T | -0.99359194 | D144 | D144N | -0.7719199 | V42 | L40V | -0.52506128 | A50 | V52I | -0.38046301 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for METTL21A from PDB |
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Differential gene expression and gene-gene network for METTL21A |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for METTL21A |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for METTL21A |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of METTL21A go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4lec | A | V42 A50 R95 D144 | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4lec | B | V42 A50 R95 D144 |
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Conservation information for LBS of METTL21A |
Multiple alignments for Q8WXB1 in multiple species |
LBS | AA sequence | # species | Species | A143 | DLILGADIIYL | 2 | Homo sapiens, Bos taurus | A143 | DFILGADIIYL | 1 | Xenopus tropicalis | A143 | DLILGADIVYL | 1 | Danio rerio | A143 | DLILGADVIYL | 1 | Mus musculus | A43 | KQLGVAAVVWD | 2 | Xenopus tropicalis, Bos taurus | A43 | RHLGVAAVVWD | 1 | Homo sapiens | A43 | KRLGVAAVVWD | 1 | Danio rerio | A43 | RQLGVAAVVWD | 1 | Mus musculus | A50 | VVWDAAIVLST | 1 | Homo sapiens | A50 | VVWDAALVLCM | 1 | Xenopus tropicalis | A50 | VVWDAAVVLCM | 1 | Danio rerio | A50 | VVWDAAVVLAT | 1 | Bos taurus | A50 | VVWDAAVVLSM | 1 | Mus musculus | A74 | AVELGAGTGLV | 3 | Homo sapiens, Bos taurus, Mus musculus | A74 | VIELGAGTGLV | 2 | Xenopus tropicalis, Danio rerio | D144 | LILGADIIYLE | 2 | Homo sapiens, Bos taurus | D144 | FILGADIIYLE | 1 | Xenopus tropicalis | D144 | LILGADIVYLE | 1 | Danio rerio | D144 | LILGADVIYLE | 1 | Mus musculus | D94 | HVTITDRKVAL | 2 | Homo sapiens, Bos taurus | D94 | QVTITDRDLAM | 1 | Xenopus tropicalis | D94 | NVTITDREPAL | 1 | Danio rerio | D94 | QVTITDRKVAL | 1 | Mus musculus | G73 | SAVELGAGTGL | 3 | Homo sapiens, Bos taurus, Mus musculus | G73 | SVIELGAGTGL | 1 | Xenopus tropicalis | G73 | RVIELGAGTGL | 1 | Danio rerio | G75 | VELGAGTGLVG | 3 | Homo sapiens, Bos taurus, Mus musculus | G75 | IELGAGTGLVG | 2 | Xenopus tropicalis, Danio rerio | L123 | AVVKELTWGQN | 2 | Bos taurus, Mus musculus | L123 | TVVKELTWGQN | 1 | Homo sapiens | L123 | VSVRALNWGKS | 1 | Xenopus tropicalis | L123 | VQVSELTWGEN | 1 | Danio rerio | R95 | VTITDRKVALE | 3 | Homo sapiens, Bos taurus, Mus musculus | R95 | VTITDRDLAME | 1 | Xenopus tropicalis | R95 | VTITDREPALE | 1 | Danio rerio | T124 | VVKELTWGQNL | 3 | Homo sapiens, Bos taurus, Mus musculus | T124 | SVRALNWGKSL | 1 | Xenopus tropicalis | T124 | QVSELTWGENL | 1 | Danio rerio | V42 | WKQLGVAAVVW | 2 | Xenopus tropicalis, Bos taurus | V42 | WRHLGVAAVVW | 1 | Homo sapiens | V42 | WKRLGVAAVVW | 1 | Danio rerio | V42 | WRQLGVAAVVW | 1 | Mus musculus | V45 | LGVAAVVWDAA | 5 | Homo sapiens, Xenopus tropicalis, Danio rerio, Bos taurus, Mus musculus | V46 | GVAAVVWDAAV | 3 | Danio rerio, Bos taurus, Mus musculus | V46 | GVAAVVWDAAI | 1 | Homo sapiens | V46 | GVAAVVWDAAL | 1 | Xenopus tropicalis | W125 | VKELTWGQNLG | 2 | Homo sapiens, Bos taurus | W125 | VRALNWGKSLE | 1 | Xenopus tropicalis | W125 | VSELTWGENLD | 1 | Danio rerio | W125 | VKELTWGQNLE | 1 | Mus musculus | W47 | VAAVVWDAAVV | 3 | Danio rerio, Bos taurus, Mus musculus | W47 | VAAVVWDAAIV | 1 | Homo sapiens | W47 | VAAVVWDAALV | 1 | Xenopus tropicalis | Y147 | GADIIYLEETF | 3 | Homo sapiens, Xenopus tropicalis, Bos taurus | Y147 | GADIVYLEETF | 1 | Danio rerio | Y147 | GADVIYLEDTF | 1 | Mus musculus |
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