|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for DAPK3 |
 Gene summary |
| Basic gene Info. | Gene symbol | DAPK3 |
| Gene name | death-associated protein kinase 3 | |
| Synonyms | DLK|ZIP|ZIPK | |
| Cytomap | UCSC genome browser: 19p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001348.2, | |
| Description | DAP kinase 3DAP-like kinaseMYPT1 kinaseZIP-kinasezipper-interacting protein kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603289 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000167657 | ||
| HPRD : 04478 | ||
| Vega : OTTHUMG00000181825 | ||
| Protein | UniProt: O43293 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DAPK3 | |
| BioGPS: 1613 | ||
| Pathway | NCI Pathway Interaction Database: DAPK3 | |
| KEGG: DAPK3 | ||
| REACTOME: DAPK3 | ||
| Pathway Commons: DAPK3 | ||
| Context | iHOP: DAPK3 | |
| ligand binding site mutation search in PubMed: DAPK3 | ||
| UCL Cancer Institute: DAPK3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 10356987 | GO:0006915 | apoptotic process | 10580117 | GO:0017148 | negative regulation of translation | 18995835 | GO:0035556 | intracellular signal transduction | 10356987 | GO:0043065 | positive regulation of apoptotic process | 21487036 | GO:0046777 | protein autophosphorylation | 18239682 | GO:0051893 | regulation of focal adhesion assembly | 23454120 | GO:0071346 | cellular response to interferon-gamma | 18995835 | GO:2000249 | regulation of actin cytoskeleton reorganization | 23454120 |
| Top |
| Ligand binding site mutations for DAPK3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D161 | D161G | COAD | 1 | D161 | D161N | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for DAPK3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D161 | D161G | -1.7073195 | D161 | D161N | -1.6037364 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DAPK3 from PDB |
| Top |
| Differential gene expression and gene-gene network for DAPK3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for DAPK3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for DAPK3 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04716 | 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE | Small molecule |  |
| Experimental | DB07125 | 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid | Small molecule |  |
| Experimental | DB07242 | (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of DAPK3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | IZA | 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE | 2j90 | A | D161 | IZA | 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE | 2j90 | B | D161 | 7CP | (4R)-7,8-DICHLORO-1',9-DIMETHYL-1-OXO-1,2,4,9-TETRAHYDROSPIRO[BETA-CARBOLINE-3,4'-PIPERIDINE]-4-CARBONITRILE | 3bhy | A | D161 | 4RB | 4-(6-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}IMIDAZO[1,2-B]PYRIDAZIN-3-YL)BENZOIC ACID | 3bqr | A | D161 | U7E | 5-(3-SULFAMOYLPHENYL)-1H-1,2,3,4-TETRAZOL-1-IDE | 5a6n | A | D161 |
| Top |
| Conservation information for LBS of DAPK3 |
| Multiple alignments for O43293 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |