mutLBSgeneDB |
Gene summary for CABP7 |
Gene summary |
Basic gene Info. | Gene symbol | CABP7 |
Gene name | calcium binding protein 7 | |
Synonyms | CALN2 | |
Cytomap | UCSC genome browser: 22q12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_182527.2, | |
Description | calcium-binding protein 7calneuron 2calneuron IIcalneuron-2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000100314 | ||
HPRD : 12995 | ||
Vega : OTTHUMG00000151282 | ||
Protein | UniProt: Q86V35 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CABP7 | |
BioGPS: 164633 | ||
Pathway | NCI Pathway Interaction Database: CABP7 | |
KEGG: CABP7 | ||
REACTOME: CABP7 | ||
Pathway Commons: CABP7 | ||
Context | iHOP: CABP7 | |
ligand binding site mutation search in PubMed: CABP7 | ||
UCL Cancer Institute: CABP7 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CABP7 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D86 | D86N | SKCM | 2 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CABP7 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D86 | D86N | -0.98832678 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CABP7 from PDB |
PDB ID | PDB title | PDB structure | 2LV7 | Solution structure of Ca2+-bound CaBP7 N-terminal doman |
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Differential gene expression and gene-gene network for CABP7 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CABP7 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CABP7 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CABP7 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 2lv7 | A | D86 |
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Conservation information for LBS of CABP7 |
Multiple alignments for Q86V35 in multiple species |
LBS | AA sequence | # species | Species | D46 | AFKVFDRDGNG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D48 | KVFDRDGNGFI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D82 | IIQRLDMDGDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D84 | QRLDMDGDGQV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D86 | LDMDGDGQVDF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D90 | GDGQVDFEEFV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E57 | FISKQELGTAM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E93 | QVDFEEFVTLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F52 | RDGNGFISKQE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N50 | FDRDGNGFISK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q88 | MDGDGQVDFEE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V89 | DGDGQVDFEEF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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