mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CABP7
Gene summary
Basic gene Info.Gene symbolCABP7
Gene namecalcium binding protein 7
SynonymsCALN2
CytomapUCSC genome browser: 22q12.2
Type of geneprotein-coding
RefGenesNM_182527.2,
Descriptioncalcium-binding protein 7calneuron 2calneuron IIcalneuron-2
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000100314
HPRD : 12995
Vega : OTTHUMG00000151282
ProteinUniProt: Q86V35
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CABP7
BioGPS: 164633
PathwayNCI Pathway Interaction Database: CABP7
KEGG: CABP7
REACTOME: CABP7
Pathway Commons: CABP7
ContextiHOP: CABP7
ligand binding site mutation search in PubMed: CABP7
UCL Cancer Institute: CABP7
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CABP7
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D86D86NSKCM2
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CABP7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D86D86N-0.98832678
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CABP7 from PDB
PDB IDPDB titlePDB structure
2LV7Solution structure of Ca2+-bound CaBP7 N-terminal doman

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Differential gene expression and gene-gene network for CABP7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CABP7 and the right PPI network was created from samples without mutations in the LBS of CABP7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CABP7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CABP7
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CABP7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)2lv7AD86


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Conservation information for LBS of CABP7
Multiple alignments for Q86V35 in multiple species
LBSAA sequence# speciesSpecies
D46AFKVFDRDGNG3Homo sapiens, Mus musculus, Rattus norvegicus
D48KVFDRDGNGFI3Homo sapiens, Mus musculus, Rattus norvegicus
D82IIQRLDMDGDG3Homo sapiens, Mus musculus, Rattus norvegicus
D84QRLDMDGDGQV3Homo sapiens, Mus musculus, Rattus norvegicus
D86LDMDGDGQVDF3Homo sapiens, Mus musculus, Rattus norvegicus
D90GDGQVDFEEFV3Homo sapiens, Mus musculus, Rattus norvegicus
E57FISKQELGTAM3Homo sapiens, Mus musculus, Rattus norvegicus
E93QVDFEEFVTLL3Homo sapiens, Mus musculus, Rattus norvegicus
F52RDGNGFISKQE3Homo sapiens, Mus musculus, Rattus norvegicus
N50FDRDGNGFISK3Homo sapiens, Mus musculus, Rattus norvegicus
Q88MDGDGQVDFEE3Homo sapiens, Mus musculus, Rattus norvegicus
V89DGDGQVDFEEF3Homo sapiens, Mus musculus, Rattus norvegicus


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