mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DECR1
Gene summary
Basic gene Info.Gene symbolDECR1
Gene name2,4-dienoyl CoA reductase 1, mitochondrial
SynonymsDECR|NADPH|SDR18C1
CytomapUCSC genome browser: 8q21.3
Type of geneprotein-coding
RefGenesNM_001359.1,
Description2,4-dienoyl-CoA reductase, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C, member 1
Modification date20141207
dbXrefs MIM : 222745
HGNC : HGNC
Ensembl : ENSG00000104325
HPRD : 01959
Vega : OTTHUMG00000163829
ProteinUniProt: Q16698
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DECR1
BioGPS: 1666
PathwayNCI Pathway Interaction Database: DECR1
KEGG: DECR1
REACTOME: DECR1
Pathway Commons: DECR1
ContextiHOP: DECR1
ligand binding site mutation search in PubMed: DECR1
UCL Cancer Institute: DECR1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006635fatty acid beta-oxidation15531764
GO:0051289protein homotetramerization15531764


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Ligand binding site mutations for DECR1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R91R91PBRCA1
S157S157FCOAD1
T69T69ACOAD1
V118V118MGBM1
I164T165SSTAD1
G241P242HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for DECR1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T69T69A0.014896295
G241P242H-1.6306043
I164T165S-1.4337878
V118V118M-0.83634601
R91R91P-0.64125519
S157S157F-0.49747059
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DECR1 from PDB

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Differential gene expression and gene-gene network for DECR1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DECR1 and the right PPI network was created from samples without mutations in the LBS of DECR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for DECR1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023772Lipid Metabolism, Inborn Errors1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for DECR1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule
ExperimentalDB086056-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OLSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DECR1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
HXCHEXANOYL-COA(4-)1w6uBR91 S157
HXCHEXANOYL-COA(4-)1w6uDR91 S157 I164
HXCHEXANOYL-COA(4-)1w6uAS157
HXCHEXANOYL-COA(4-)1w6uCS157
NAPNADP ZWITTERION1w6uAT69 R91 V118 G241
NAPNADP ZWITTERION1w6uBT69 R91 V118 G241
NAPNADP ZWITTERION1w6uCT69 R91 V118 G241
NAPNADP ZWITTERION1w6uDT69 R91 V118 G241
NAPNADP ZWITTERION1w73AT69 R91 V118 G241
NAPNADP ZWITTERION1w73BT69 R91 V118 G241
NAPNADP ZWITTERION1w73CT69 R91 V118 G241
NAPNADP ZWITTERION1w73DT69 R91 V118 G241
NAPNADP ZWITTERION1w8dAT69 R91 V118 G241
NAPNADP ZWITTERION1w8dBT69 R91 V118 G241
NAPNADP ZWITTERION1w8dCT69 R91 V118 G241
NAPNADP ZWITTERION1w8dDT69 R91 V118 G241


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Conservation information for LBS of DECR1
Multiple alignments for Q16698 in multiple species
LBSAA sequence# speciesSpecies
A145VVINNAAGNFI2Mus musculus, Rattus norvegicus
A145IVINNAAGNFI1Homo sapiens
A146VINNAAGNFIS3Homo sapiens, Mus musculus, Rattus norvegicus
A160RLSPNAWKTIT1Homo sapiens
A160RLTPNGWKTIT1Mus musculus
A160RLSPNGWKTIT1Rattus norvegicus
C116VHAIQCDVRDP1Homo sapiens
C116VHAIRCDVRDP1Mus musculus
C116VYAIRCDVRDP1Rattus norvegicus
D117HAIQCDVRDPD1Homo sapiens
D117HAIRCDVRDPD1Mus musculus
D117YAIRCDVRDPD1Rattus norvegicus
E275RLGTVEELANL2Homo sapiens, Rattus norvegicus
E275RLGTMEELANL1Mus musculus
E310VFLSGEFNSLK2Mus musculus, Rattus norvegicus
E310VLISGEFNDLR1Homo sapiens
E326QWDTIEELIRK1Homo sapiens
E326EWDIIEGLIRK1Mus musculus
E326EWDVIEGLIRK1Rattus norvegicus
F149NAAGNFISPSE2Mus musculus, Rattus norvegicus
F149NAAGNFISPTE1Homo sapiens
F311FLSGEFNSLKK2Mus musculus, Rattus norvegicus
F311LISGEFNDLRK1Homo sapiens
G147INNAAGNFISP3Homo sapiens, Mus musculus, Rattus norvegicus
G241NIIQPGPIKTK2Mus musculus, Rattus norvegicus
G241NVIQPGPIKTK1Homo sapiens
G66VAFITGGGTGL3Homo sapiens, Mus musculus, Rattus norvegicus
G70TGGGTGLGKAM2Mus musculus, Rattus norvegicus
G70TGGGTGLGKGM1Homo sapiens
I150AAGNFISPSER2Mus musculus, Rattus norvegicus
I150AAGNFISPTER1Homo sapiens
I164NGWKTITDIVL2Mus musculus, Rattus norvegicus
I164NAWKTITDIVL1Homo sapiens
I167KTITDIVLNGT3Homo sapiens, Mus musculus, Rattus norvegicus
I195AAFLAITTIYA2Mus musculus, Rattus norvegicus
I195AAFLSITTIYA1Homo sapiens
K214PSSSAKSGVEA2Mus musculus, Rattus norvegicus
K214PSASAKAGVEA1Homo sapiens
K92VIASRNIDVLK2Mus musculus, Rattus norvegicus
K92VIASRKMDVLK1Homo sapiens
L156SPTERLSPNAW1Homo sapiens
L156SPSERLTPNGW1Mus musculus
L156SPSERLSPNGW1Rattus norvegicus
L71GGGTGLGKAMT2Mus musculus, Rattus norvegicus
L71GGGTGLGKGMT1Homo sapiens
N144DVVINNAAGNF2Mus musculus, Rattus norvegicus
N144NIVINNAAGNF1Homo sapiens
N148NNAAGNFISPS2Mus musculus, Rattus norvegicus
N148NNAAGNFISPT1Homo sapiens
N159ERLSPNAWKTI1Homo sapiens
N159ERLTPNGWKTI1Mus musculus
N159ERLSPNGWKTI1Rattus norvegicus
P240FNIIQPGPIKT2Mus musculus, Rattus norvegicus
P240FNVIQPGPIKT1Homo sapiens
R91CVIASRNIDVL2Mus musculus, Rattus norvegicus
R91CVIASRKMDVL1Homo sapiens
S157PTERLSPNAWK1Homo sapiens
S157PSERLTPNGWK1Mus musculus
S157PSERLSPNGWK1Rattus norvegicus
S210GFVMPSSSAKS2Mus musculus, Rattus norvegicus
S210GFVVPSASAKA1Homo sapiens
S90QCVIASRNIDV2Mus musculus, Rattus norvegicus
S90QCVIASRKMDV1Homo sapiens
T163PNGWKTITDIV2Mus musculus, Rattus norvegicus
T163PNAWKTITDIV1Homo sapiens
T196AFLAITTIYAE2Mus musculus, Rattus norvegicus
T196AFLSITTIYAE1Homo sapiens
T197FLAITTIYAES2Mus musculus, Rattus norvegicus
T197FLSITTIYAET1Homo sapiens
T69ITGGGTGLGKA2Mus musculus, Rattus norvegicus
T69ITGGGTGLGKG1Homo sapiens
V118AIRCDVRDPDM2Mus musculus, Rattus norvegicus
V118AIQCDVRDPDM1Homo sapiens
Y199AITTIYAESGS2Mus musculus, Rattus norvegicus
Y199SITTIYAETGS1Homo sapiens


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